Proximity effect on hydrodynamic interaction between a sphere and a plane measured by Force Feedback Microscopy at different frequencies

In this article, we measure the viscous damping $G'',$ and the associated stiffness $G',$ of a liquid flow in sphere-plane geometry in a large frequency range. In this regime, the lubrication approximation is expected to dominate. We first measure the static force applied to the tip. This is made possible thanks to a force feedback method. Adding a sub-nanometer oscillation of the tip, we obtain the dynamic part of the interaction with solely the knowledge of the lever properties in the experimental context using a linear transformation of the amplitude and phase change. Using a Force Feedback Microscope (FFM)we are then able to measure simultaneously the static force, the stiffness and the dissipative part of the interaction in a broad frequency range using a single AFM probe. Similar measurements have been performed by the Surface Force Apparatus with a probe radius hundred times bigger. In this context the FFM can be called nano-SFA

El olvido de la lengua materna y sus consecuencias en la formación del profesorado de idiomas. Intervención y mejora de degradación de la competencia lingüística y docente del profesorado nativo

Esta Tesis Doctoral estudia el olvido - o atrición - de la lengua materna en adultos con una triple finalidad: - Analiza el concepto de atrición en la edad adulta y aclara el estado de la discusión científica sobre este fenómeno poco estudiado en España. Explica el olvido de la lengua materna (también llamada L1 o lengua primera, para distinguirla de la L2 o lengua segunda) desde un enfoque pluridisciplinar, relacionándolo con el funcionamiento cognitivo cerebral y sus mecanismos mnemónicos y situándolo en la realidad compleja del bilingüismo y plurilingüismo. - Realiza un estudio de caracterización de los efectos de la atrición, situándose en el contexto franco-español y analizando el olvido desde una perspectiva lingüística e interpretativa. Considera el olvido del idioma materno francés de una población de adultos inmersos de forma continua y prolongada en un entorno hispanohablante, tratándose de una combinación de idiomas no estudiada hasta ahora en este contexto lingüístico. Por una parte, la investigación se centra en el análisis de la producción discursiva de este público - estudiando el idioma hablado en los datos obtenidos y confrontándolo con la norma nativa francesa - y en el estudio de los comportamientos compensatorios de comunicación encontrados. Por otra parte, este trabajo explora la dimensión psicolingüística del olvido, interpretando el discurso formulado en el corpus sobre la práctica del francés en este ámbito. - Profundiza y concreta su nivel de reflexión considerando al público específico de los profesores nativos de idiomas en una posible situación de olvido de su lengua materna. Pone de manifiesto el peligro que representa la atrición en su actividad profesional y propone informar e intervenir a dos niveles diferentes (pre o post atrición), formulando respectivamente unas propuestas de actuaciones preventivas y de técnicas de apoyo y mejora de la competencia lingüística y docente de estos profesionales..

Giant slip lengths of a simple fluid at vibrating solid interfaces

It has been shown recently [PRL 102, 254503 (2009)] that in the plane-plane configuration a mechanical resonator vibrating close to a rigid wall in a simple fluid can be overdamped to a frozen regime. Here, by solving analytically the Navier Stokes equations with partial slip boundary conditions at the solid fluid interface, we develop a theoretical approach justifying and extending these earlier findings. We show in particular that in the perfect slip regime the above mentioned results are, in the plane-plane configuration, very general and robust with respect to lever geometry considerations. We compare the results with those obtained previously for the sphere moving perpendicularly and close to a plane in a simple fluid and discuss in more details the differences concerning the dependence of the friction forces with the gap distance separating the moving object (i.e., plane or sphere) from the fixed plane. Finally, we show that the submicron fluidic effect reported in the reference above, and discussed further in the present work, can have dramatic implications in the design of nano-electromechanical systems (NEMS).Comment: submitted to PRE (see also PRL 102, 254503 (2009)

Pathways into services for offenders with intellectual disabilities : childhood experience, diagnostic information and offence variables

The patterns and pathways into intellectual disability (ID) offender services were studied through case file review for 477 participants referred in one calendar year to community generic, community forensic, and low, medium, and maximum secure services. Data were gathered on referral source, demographic information, index behavior, prior problem behaviors, diagnostic information, and abuse or deprivation. Community referrers tended to refer to community services and secure service referrers to secure services. Physical and verbal violence were the most frequent index behaviors, whereas contact sexual offenses were more prominent in maximum security. Age at first incident varied with security, with the youngest in maximum secure services. Attention-deficit/hyperactivity disorder or conduct disorder was the most frequently recorded diagnosis, and severe deprivation was the most frequent adverse developmental experience. Fire starting, theft, and road traffic offenses did not feature prominently. Generic community services accepted a number of referrals with forensic-type behavior and had higher proportions of both women and people with moderate or severe ID

Structure of Tagatose-1,6-bisphosphate Aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases

Tagatose-1,6-bisphosphate aldolase (TBPA) is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate. The high resolution (1.45 Å) crystal structure of the Escherichia coli enzyme, encoded by the agaY gene, complexed with phosphoglycolohydroxamate (PGH) has been determined. Two subunits comprise the asymmetric unit, and a crystallographic 2-fold axis generates the functional tetramer. A complex network of hydrogen bonds position side chains in the active site that is occupied by two cations. An unusual Na(+) binding site is created using a interaction with Tyr(183) in addition to five oxygen ligands. The catalytic Zn(2+) is five-coordinate using three histidine nitrogens and two PGH oxygens. Comparisons of TBPA with the related fructose-1,6-bisphosphate aldolase (FBPA) identifies common features with implications for the mechanism. Because the major product of the condensation catalyzed by the enzymes differs in the chirality at a single position, models of FBPA and TBPA with their cognate bisphosphate products provide insight into chiral discrimination by these aldolases. The TBPA active site is more open on one side than FBPA, and this contributes to a less specific enzyme. The availability of more space and a wider range of aldehyde partners used by TBPA together with the highly specific nature of FBPA suggest that TBPA might be a preferred enzyme to modify for use in biotransformation chemistry

Urinary Biomarkers of Prenatal Atrazine Exposure and Adverse Birth Outcomes in the PELAGIE Birth Cohort

Background: Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies—and fewer epidemiologic investigations—have examined the potential effects of prenatal exposure

Casimir-Polder force between an atom and a dielectric plate: thermodynamics and experiment

The low-temperature behavior of the Casimir-Polder free energy and entropy for an atom near a dielectric plate are found on the basis of the Lifshitz theory. The obtained results are shown to be thermodynamically consistent if the dc conductivity of the plate material is disregarded. With inclusion of dc conductivity, both the standard Lifshitz theory (for all dielectrics) and its generalization taking into account screening effects (for a wide range of dielectrics) violate the Nernst heat theorem. The inclusion of the screening effects is also shown to be inconsistent with experimental data of Casimir force measurements. The physical reasons for this inconsistency are elucidated.Comment: 10 pages, 1 figure; improved discussion; to appear in J. Phys. A: Math. Theor. (Fast Track Communications

Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations

The immune system makes decisions in response to combinations of multiple microbial inputs. We do not understand the combinatorial logic governing how higher-order combinations of microbial signals shape immune responses. Here, using coculture experiments and statistical analyses, we discover a general property for the combinatorial sensing of microbial signals, whereby the effects of triplet combinations of microbial signals on immune responses can be predicted by combining the effects of single and pairs. Mechanistically, we find that singles and pairs dictate the information signaled by triplets in mouse and human DCs at the levels of transcription, chromatin, and protein secretion. We exploit this simplifying property to develop cell-based immunotherapies prepared with adjuvant combinations that trigger protective responses in mouse models of cancer. We conclude that the processing of multiple input signals by innate immune cells is governed by pairwise effects, which will inform the rationale combination of adjuvants to manipulate immunity

Analytical and Numerical Demonstration of How the Drude Dispersive Model Satisfies Nernst's Theorem for the Casimir Entropy

In view of the current discussion on the subject, an effort is made to show very accurately both analytically and numerically how the Drude dispersive model, assuming the relaxation is nonzero at zero temperature (which is the case when impurities are present), gives consistent results for the Casimir free energy at low temperatures. Specifically, we find that the free energy consists essentially of two terms, one leading term proportional to T^2, and a next term proportional to T^{5/2}. Both these terms give rise to zero Casimir entropy as T -> 0, thus in accordance with Nernst's theorem.Comment: 11 pages, 4 figures; minor changes in the discussion. Contribution to the QFEXT07 proceedings; matches version to be published in J. Phys.