Dynamics of rapidly spinning blob-filaments: fluid theory with a parallel kinetic extension

Blob-filaments (or simply 'blobs') are coherent structures formed by turbulence and sustained by nonlinear processes in the edge and scrape-off layer (SOL) of tokamaks and other magnetically confined plasmas. The dynamics of these blob-filaments, in particular their radial motion, can influence the scrape-off layer width and plasma interactions with both the divertor target and with the main chamber walls. Motivated by recent results from the XGC1 gyrokinetic simulation code reported on elsewhere [J. Cheng et al. submitted to Nucl. Fusion and available at arXiv:2302.02877v1], a theory of rapidly spinning blob-filaments has been developed. The theory treats blob filaments in the closed flux surface region or the region that is disconnected from sheaths in the SOL. It extends previous work by treating blob spin, arising from partially or fully adiabatic electrons, as the leading order effect and retaining inertial (ion charge polarization) physics in next order. Spin helps to maintain blob coherency and affects the blob's propagation speed. Dipole charge polarization, treated perturbatively, gives rise to blob-filaments with relatively slow radial velocity, comparable to that observed in the simulations. The theory also treats the interaction of rapidly spinning blob filaments with a zonal flow layer. It is shown analytically that the flow layer can act like a transport barrier for these structures. Finally parallel electron kinetic effects are incorporated into the theory. Various asymptotic parameter regimes are discussed and asymptotic expressions for the radial and poloidal motion of the blob-filaments are obtained.Comment: 31 pages, 2 figures, accepted in the journal Physics of Plasmas 30, 072302 (2023

Oblique radiative shocks, including their interactions with nonradiative polytropic shocks

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98755/1/PhysPlasmas_18_056901.pd

Atrazine management and water quality (1999)

New 1/99/20M

Dispelling the myths of online education: learning via the information superhighway

There continues to be a perception that online education is inferior to traditional education. In the U.S. online learning is more developed than in the U.K. This paper provides insights into a U.S. provision and takes a close look at what are perceived as weaknesses of on line learning and argues that these are not necessarily inherent weaknesses of this form of educational delivery. Then, results of two major studies, undertaken in the U.S. are provided comparing the effectiveness of online education to traditional education as perceived by current MBA students and past graduates. Results of these studies suggest that students of MBA modules and MBA graduates perceive the quality and effectiveness of online education to be similar to, if not higher than, the quality and effectiveness of traditional modules and programmes

Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and increased metastasis. Although hypoxia has been correlated with factors associated with the latter stages of cancer progression, it is not well documented how hypoxia influences cells in the earliest stages of transformation. Using the immortalized MCF-10A breast epithelial cell line, we used hypoxic culture conditions to mimic reduced O2 levels found within early pre-malignant lesions and assessed various cellular parameters. In this non-transformed mammary cell line, O2 deprivation led to some changes not immediately associated with cancer progression, such as decreased proliferation, cell cycle arrest and increased apoptosis. In contrast, hypoxia did induce other changes more consistent with an increased metastatic potential. A rise in the CD44+CD24-/low-labeled cell sub-population along with increased colony forming capability indicated an expanded stem cell population. Hypoxia also induced cellular and molecular changes consistent with an epithelial-to-mesenchymal transition (EMT). Furthermore, these cells now exhibited increased migratory and invasive abilities. These results underscore the contribution of the hypoxic tumour microenvironment in cancer progression and dissemination

Docosahexaenoic acid counteracts palmitate-induced endoplasmic reticulum stress in C2C12 myotubes: Impact on muscle atrophy

Lipid accumulation in skeletal muscle results in dysregulation of protein meta- bolism and muscle atrophy. We previously reported that treating C2C12 myo- tubes with palmitate (PA), a saturated fatty acid, increases the overall rate of proteolysis via activation of the ubiquitin-proteasome and autophagy systems; co-treatment with the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) prevents the PA-induced responses. Others have reported that PA induces endoplasmic reticulum (ER) stress which initiates the unfolded pro- tein response (UPR), a collective group of responses that can lead to activa- tion of caspase-mediated proteolysis and autophagy. Presently, we tested the hypothesis that DHA protects against PA-induced ER stress/UPR and its atro- phy-related responses in muscle cells. C2C12 myotubes were treated with 500 lmol/L PA and/or 100 lmol/L DHA for 24 h. Proteins and mRNA asso- ciated with ER stress/UPR, autophagy, and caspase-3 activation were evalu- ated. PA robustly increased the phosphorylation of protein kinase R (PKR)- like ER kinase (PERK) and eukaryotic initiation factor 2a (eIF2a). It also increased the mRNAs encoding activating transcription factor 4 (ATF4), spliced X-box binding protein 1 (XBP1s), C/EBP homologous protein (CHOP), and autophagy-related 5 (Atg5) as well as the protein levels of the PERK target nuclear factor erythroid 2-related factor (Nrf2), CHOP, and cleaved (i.e., activated) caspase-3. Co-treatment with DHA prevented all of the PA-induced responses. Our results indicate that DHA prevents PA- induced muscle cell atrophy, in part, by preventing ER stress/UPR, a process that leads to activation of caspase-mediated proteolysis and an increase in expression of autophagy-related genes

Instabilities of one-dimensional stationary solutions of the cubic nonlinear Schrodinger equation

The two-dimensional cubic nonlinear Schrodinger equation admits a large family of one-dimensional bounded traveling-wave solutions. All such solutions may be written in terms of an amplitude and a phase. Solutions with piecewise constant phase have been well studied previously. Some of these solutions were found to be stable with respect to one-dimensional perturbations. No such solutions are stable with respect to two-dimensional perturbations. Here we consider stability of the larger class of solutions whose phase is dependent on the spatial dimension of the one-dimensional wave form. We study the spectral stability of such nontrivial-phase solutions numerically, using Hill's method. We present evidence which suggests that all such nontrivial-phase solutions are unstable with respect to both one- and two-dimensional perturbations. Instability occurs in all cases: for both the elliptic and hyperbolic nonlinear Schrodinger equations, and in the focusing and defocusing case.Comment: Submitted: 13 pages, 3 figure

Nucleon Spin Fluctuations and the Supernova Emission of Neutrinos and Axions

In the hot and dense medium of a supernova (SN) core, the nucleon spins fluctuate so fast that the axial-vector neutrino opacity and the axion emissivity are expected to be significantly modified. Axions with m_a\alt10^{-2}\,{\rm eV} are not excluded by SN~1987A. A substantial transfer of energy in neutrino-nucleon ($\nu N$) collisions is enabled which may alter the spectra of SN neutrinos relative to calculations where energy-conserving $\nu N$ collisions had been assumed near the neutrinosphere.Comment: 8 pages. REVTeX. 2 postscript figures, can be included with epsf. Small modifications of the text, a new "Note Added", and three new references. To be published in Phys. Rev. Let

Aspirin Use and Incident Cardiovascular Disease, Kidney Failure, and Death in Stable Kidney Transplant Recipients: A Post Hoc Analysis of the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial

Cardiovascular disease (CVD) is the leading cause of death in kidney transplant recipients. Whether aspirin may reduce the risk for CVD, death, and kidney failure outcomes is uncertain

Randomized controlled trial of a health plan-level mood disorders psychosocial intervention for solo or small practices

Background: Mood disorders represent the most expensive mental disorders for employer-based commercial health plans. Collaborative care models are effective in treating chronic physical and mental illnesses at little to no net healthcare cost, but to date have primarily been implemented by larger healthcare organizations in facility-based models. The majority of practices providing commercially insured care are far too small to implement such models. Health plan-level collaborative care treatment can address this unmet need. The goal of this study is to implement at the national commercial health plan level a collaborative care model to improve outcomes for persons with mood disorders. Methods/Design A randomized controlled trial of a collaborative care model versus usual care will be conducted among beneficiaries of a large national health plan from across the country seen by primary care or behavioral health practices. At discharge 344 patients identified by health plan claims as hospitalized for unipolar depression or bipolar disorder will be randomized to receive collaborative care (patient phone-based self-management support, care management, and guideline dissemination to practices delivered by a plan-level care manager) or usual care from their provider. Primary outcomes are changes in mood symptoms and mental health-related quality of life at 12 months. Secondary outcomes include rehospitalization, receipt of guideline-concordant care, and work productivity. Discussion This study will determine whether a collaborative care model for mood disorders delivered at the national health plan level improves outcomes compared to usual care, and will inform a business case for collaborative care models for these settings that can reach patients wherever they receive treatment. Trial registration ClinicalTrials.gov Identifier: NCT02041962; registered January 3, 2014