Fox River streamflow assessment model: 1999 update to the hydrologic analysis

"Prepared for the Illinois Department of Natural Resources, Office of Water Resources.

Surface Tension between Kaon Condensate and Normal Nuclear Matter Phase

We calculate for the first time the surface tension and curvature coefficient of a first order phase transition between two possible phases of cold nuclear matter, a normal nuclear matter phase in equilibrium with a kaon condensed phase, at densities a few times the saturation density. We find the surface tension is proportional to the difference in energy density between the two phases squared. Furthermore, we show the consequences for the geometrical structures of the mixed phase region in a neutron star.Comment: 7 pages, 5 figures (Latex

Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells.

Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C. albicans hyphae invade endothelial cells and oral epithelial cells in vitro by inducing their own endocytosis. Therefore, we set out to identify the fungal surface protein and host cell receptors that mediate this process. We found that the C. albicans Als3 is required for the organism to be endocytosed by human umbilical vein endothelial cells and two different human oral epithelial lines. Affinity purification experiments with wild-type and an als3delta/als3delta mutant strain of C. albicans demonstrated that Als3 was required for C. albicans to bind to multiple host cell surface proteins, including N-cadherin on endothelial cells and E-cadherin on oral epithelial cells. Furthermore, latex beads coated with the recombinant N-terminal portion of Als3 were endocytosed by Chinese hamster ovary cells expressing human N-cadherin or E-cadherin, whereas control beads coated with bovine serum albumin were not. Molecular modeling of the interactions of the N-terminal region of Als3 with the ectodomains of N-cadherin and E-cadherin indicated that the binding parameters of Als3 to either cadherin are similar to those of cadherin-cadherin binding. Therefore, Als3 is a fungal invasin that mimics host cell cadherins and induces endocytosis by binding to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells. These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins

Streamflow assessment model for the Little Wabash River watershed: hydrologic analysis

"Contract report 2001-14.""August 2001.""Prepared for the Illinois Department of Natural Resources, Office of Water Resources.

Planetary Collisions outside the Solar System: Time Domain Characterization of Extreme Debris Disks

Luminous debris disks of warm dust in the terrestrial planet zones around solar-like stars are recently found to vary, indicative of ongoing large-scale collisions of rocky objects. We use Spitzer 3.6 and 4.5 {\mu}m time-series observations in 2012 and 2013 (extended to 2014 in one case) to monitor 5 more debris disks with unusually high fractional luminosities ("extreme debris disk"), including P1121 in the open cluster M47 (80 Myr), HD 15407A in the AB Dor moving group (80 Myr), HD 23514 in the Pleiades (120 Myr), HD 145263 in the Upper Sco Association (10 Myr), and the field star BD+20 307 (>1 Gyr). Together with the published results for ID8 in NGC 2547 (35 Myr), this makes the first systematic time-domain investigation of planetary impacts outside the solar system. Significant variations with timescales shorter than a year are detected in five out of the six extreme debris disks we have monitored. However, different systems show diverse sets of characteristics in the time domain, including long-term decay or growth, disk temperature variations, and possible periodicity.Comment: 50 pages, 14 figures, 9 tables; Accepted for publication in the Astrophysical Journa

Evolutionary Signatures in the Formation of Low-Mass Protostars. II. Towards Reconciling Models and Observations

A long-standing problem in low-mass star formation is the "luminosity problem," whereby protostars are underluminous compared to the accretion luminosity expected both from theoretical collapse calculations and arguments based on the minimum accretion rate necessary to form a star within the embedded phase duration. Motivated by this luminosity problem, we present a set of evolutionary models describing the collapse of low-mass, dense cores into protostars, using the Young & Evans (2005) model as our starting point. We calculate the radiative transfer of the collapsing cores throughout the full duration of the collapse in two dimensions. From the resulting spectral energy distributions, we calculate standard observational signatures to directly compare to observations. We incorporate several modifications and additions to the original Young & Evans model in an effort to better match observations with model predictions. We find that scattering, 2-D geometry, mass-loss, and outflow cavities all affect the model predictions, as expected, but none resolve the luminosity problem. A cycle of episodic mass accretion, however, can resolve this problem and bring the model predictions into better agreement with observations. Standard assumptions about the interplay between mass accretion and mass loss in our model give star formation efficiencies consistent with recent observations that compare the core mass function (CMF) and stellar initial mass function (IMF). The combination of outflow cavities and episodic mass accretion reduce the connection between observational Class and physical Stage to the point where neither of the two common observational signatures (bolometric temperature and ratio of bolometric to submillimeter luminosity) can be considered reliable indicators of physical Stage.Comment: 27 pages. Accepted for publication in Ap

Maternal Factors as Moderators or Mediators of PTSD Symptoms in Very Young Children: A Two-Year Prospective Study

Research has suggested that parenting behaviors and other parental factors impact the long-term outcome of children’s posttraumatic stress disorder (PTSD) symptoms. In a sample of 62 children between the ages of one and six who experienced life-threatening traumas, PTSD was measured prospectively two years apart. Seven maternal factors were measured in a multi-method, multi-informant design. Both moderation and mediation models, with different theoretical and mechanism implications, were tested. Moderation models were not significant. Mediation models were significant when the mediator variable was maternal symptoms of PTSD or depression (measured at Time 1), self-report of maternal escape/avoidance coping (measured at Time 2), or self-report emotional sensitivity (measured at Time 2). Greater maternal emotional sensitivity was associated with greater Time 2 PTSD symptoms among children. Observational measures of emotional sensitivity as the mediator were not supported. Correlation of parents’ and children’s symptoms is a robust finding, however caution is warranted in attributing children’s PTSD symptoms to insensitive parenting

Estimating and Reporting on the Quality of Inpatient Stroke Care by Veterans Health Administration Medical Centers

Background—Reporting of quality indicators (QIs) in Veterans Health Administration Medical Centers is complicated by estimation error caused by small numbers of eligible patients per facility. We applied multilevel modeling and empirical Bayes (EB) estimation in addressing this issue in performance reporting of stroke care quality in the Medical Centers. Methods and Results—We studied a retrospective cohort of 3812 veterans admitted to 106 Medical Centers with ischemic stroke during fiscal year 2007. The median number of study patients per facility was 34 (range, 12–105). Inpatient stroke care quality was measured with 13 evidence-based QIs. Eligible patients could either pass or fail each indicator. Multilevel modeling of a patient's pass/fail on individual QIs was used to produce facility-level EB-estimated QI pass rates and confidence intervals. The EB estimation reduced interfacility variation in QI rates. Small facilities and those with exceptionally high or low rates were most affected. We recommended 8 of the 13 QIs for performance reporting: dysphagia screening, National Institutes of Health Stroke Scale documentation, early ambulation, fall risk assessment, pressure ulcer risk assessment, Functional Independence Measure documentation, lipid management, and deep vein thrombosis prophylaxis. These QIs displayed sufficient variation across facilities, had room for improvement, and identified sites with performance that was significantly above or below the population average. The remaining 5 QIs were not recommended because of too few eligible patients or high pass rates with little variation. Conclusions—Considerations of statistical uncertainty should inform the choice of QIs and their application to performance reporting