Association between obesity indices and cardiovascular risk factors in late adolescence in the Seychelles.

ABSTRACT: BACKGROUND: The ability of different obesity indices to predict cardiovascular risk is still debated in youth and few data are available in sub Saharan Africa. We compared the associations between several indices of obesity and cardiovascular risk factors (CVRFs) in late adolescence in the Seychelles. METHODS: We measured body mass index (BMI), waist circumference, waist/hip ratio (WHiR), waist/height ratio (WHtR) and percent fat mass (by bioimpedance) and 6 CVRFs (blood pressure, LDL-cholesterol, HDL-cholesterol, triglycerides, fasting blood glucose and uric acid) in 423 youths aged 19-20 years from the general population. RESULTS: The prevalence of overweight/obesity and several CVRFs was high, with substantial sex differences. Except for glucose in males and LDL-cholesterol in females, all obesity indices were associated with CVRFs. BMI consistently predicted CVRFs at least as well as the other indices. Linear regression on BMI had standardized regression coefficients of 0.25-0.36 for most CVRFs (p<0.01) and ROC analysis had an AUC between 60%-75% for most CVRFs. BMI also predicted well various combinations of CVRFs: 36% of male and 16% of female lean subjects (BMI <P50) had ≥2 CVRFs compared to 74% of male and 46% of female overweight subjects (BMI >P90). CONCLUSION: There was an elevated prevalence of obesity and of several CVRFs in youths in Seychelles. BMI predicted single or combined CVRFs at least as well as other simple obesity indices

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp

Funding: This work was funded by the National Institutes of Allergy and Infectious Disease (AI113390, LCM) and the National Institutes of General Medical Sciences (GM62483, LCM). The funders had no role in study design, data collection and analysis, decision topublish, or preparation of the manuscript.Non peer reviewedPublisher PD

The Origin of the Wigner Energy

Surfaces of experimental masses of even-even and odd-odd nuclei exhibit a sharp slope discontinuity at N=Z. This cusp (Wigner energy), reflecting an additional binding in nuclei with neutrons and protons occupying the same shell model orbitals, is usually attributed to neutron-proton pairing correlations. A method is developed to extract the Wigner term from experimental data. Both empirical arguments and shell-model calculations suggest that the Wigner term can be traced back to the isospin T=0 part of nuclear interaction. Our calculations reveal the rather complex mechanism responsible for the nuclear binding around the N=Z line. In particular, we find that the Wigner term cannot be solely explained in terms of correlations between the neutron-proton J=1, T=0 (deuteron-like) pairs.Comment: 10 RevTeX pages, 3 Postscript figures include

Protein Complexes are Central in the Yeast Genetic Landscape

If perturbing two genes together has a stronger or weaker effect than expected, they are said to genetically interact. Genetic interactions are important because they help map gene function, and functionally related genes have similar genetic interaction patterns. Mapping quantitative (positive and negative) genetic interactions on a global scale has recently become possible. This data clearly shows groups of genes connected by predominantly positive or negative interactions, termed monochromatic groups. These groups often correspond to functional modules, like biological processes or complexes, or connections between modules. However it is not yet known how these patterns globally relate to known functional modules. Here we systematically study the monochromatic nature of known biological processes using the largest quantitative genetic interaction data set available, which includes fitness measurements for ∼5.4 million gene pairs in the yeast Saccharomyces cerevisiae. We find that only 10% of biological processes, as defined by Gene Ontology annotations, and less than 1% of inter-process connections are monochromatic. Further, we show that protein complexes are responsible for a surprisingly large fraction of these patterns. This suggests that complexes play a central role in shaping the monochromatic landscape of biological processes. Altogether this work shows that both positive and negative monochromatic patterns are found in known biological processes and in their connections and that protein complexes play an important role in these patterns. The monochromatic processes, complexes and connections we find chart a hierarchical and modular map of sensitive and redundant biological systems in the yeast cell that will be useful for gene function prediction and comparison across phenotypes and organisms. Furthermore the analysis methods we develop are applicable to other species for which genetic interactions will progressively become more available

The Extreme Kerr Throat Geometry: A Vacuum Analog of AdS_2 x S^2

We study the near horizon limit of a four dimensional extreme rotating black hole. The limiting metric is a completely nonsingular vacuum solution, with an enhanced symmetry group SL(2,R) x U(1). We show that many of the properties of this solution are similar to the AdS_2 x S^2 geometry arising in the near horizon limit of extreme charged black holes. In particular, the boundary at infinity is a timelike surface. This suggests the possibility of a dual quantum mechanical description. A five dimensional generalization is also discussed.Comment: 21 page

Does prenatal methylmercury exposure from fish consumption affect blood pressure in childhood?

INTRODUCTION: Prenatal exposure to organic methylmercury (MeHg) from seafood consumption has been reported to increase children's blood pressure (BP). A report from the Faroe Islands noted significantly increased diastolic and systolic BP in 7-year-old children as prenatal MeHg exposure increased. The Faroese diet includes sea mammals that contain MeHg, cadmium, and other pollutants. We examined this relationship in the Seychelles Islands to determine if it was present in a society exposed primarily to MeHg from consuming ocean fish. METHODS: We obtained BP at ages 12 and 15 years on children with known prenatal MeHg exposure enrolled in the Seychelles Child Development Study (SCDS). We examined the association between prenatal MeHg exposure and BP using longitudinal models and linear regression adjusted for relevant covariates. RESULTS: Blood pressure at both ages was associated with BMI, height and maternal hypertension during pregnancy as expected. No association between prenatal MeHg exposure and BP was present in girls at either age or in either sex at age 12 years. At age 15 years diastolic BP in boys increased with increasing prenatal MeHg exposure, while systolic BP was unaffected. SUMMARY: It is unclear whether the association between prenatal MeHg exposure and diastolic BP seen in 15-year-old boys is of biological significance or if it is a chance finding. However, the finding is intriguing and deserves further study

The Decay of Magnetic Fields in Kaluza-Klein Theory

Magnetic fields in five-dimensional Kaluza-Klein theory compactified on a circle correspond to ``twisted'' identifications of five dimensional Minkowski space. We show that a five dimensional generalisation of the Kerr solution can be analytically continued to construct an instanton that gives rise to two possible decay modes of a magnetic field. One decay mode is the generalisation of the ``bubble decay" of the Kaluza-Klein vacuum described by Witten. The other decay mode, rarer for weak fields, corresponds in four dimensions to the creation of monopole-anti-monopole pairs. An instanton for the latter process is already known and is given by the analytic continuation of the \KK\ Ernst metric, which we show is identical to the five dimensional Kerr solution. We use this fact to illuminate further properties of the decay process. It appears that fundamental fermions can eliminate the bubble decay of the magnetic field, while allowing the pair production of Kaluza-Klein monopoles.Comment: 25 pages, one figure. The discussion of fermions has been revised: We show how fundamental fermions can eliminate the bubble-type instability but still allow pair creation of monopole