Predictors of mortality in a critical care unit in south western Kenya

Background: Critical care in developing countries has been neglected in the face of high numbers of communicable and infectious diseases like malaria, tuberculosis, HIV and Critical Care Units continue to be limited to large hospitals in urban areas. There is need to know the type of patients admitted to existing units, common diagnoses and outcomes.Objective: To determine the demographics, diagnosis and mortality of the patient population admitted to Tenwek Hospital critical care units.Method: Retrospective observational review of all patients admitted to critical care unit in Tenwek Hospital.Results: Six hundred and forty four patients admitted over a 7 month period were studied. The patients were young (32.8yrs), male and majority were from surgical service. The leading reason for admission was trauma. The overall mortality was 26.1%. Factors that significantly influenced mortality on univariate analysis were patients age (p <0.001), hospital stay (p <0.001), hospital service (p=0.002) and priority level (p<0.001). On multivariate analysis age and pediatric service were still significantly associated with increased mortality. Increased monitoring was protective OR 0.1 (95% CI 0.1-0.2, p=0.01). Of those who died 40.4% had full resuscitation, 36.8% had no resuscitation and 8.2% had withdrawal of care.Conclusion: Patients admitted to the critical care units were young, male and mainly from the surgical service with trauma being the commonest diagnosis. Age was an independent predictor of mortality and monitoring was protective.Keywords: Critical Care, Intensive Care Unit (ICU), High Dependency Unit (HDU

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Postoperative outcomes in oesophagectomy with trainee involvement

BACKGROUND: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. METHODS: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. RESULTS: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). CONCLUSION: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery

Nairobi Newborn Study: Estimating the gap between the need for and the availability, utilisation, and quality of facility-based inpatient newborn care in Nairobi, Kenya

This study assesses the current availability and quality of inpatient newborn care in hospitals in Nairobi County across all sectors. This is contrasted to the estimated need for services and desired standards of care, therefore describing two gaps: between capacity and demand; and in quality of care provided

Effective coverage of essential inpatient care for small and sick newborns in a high mortality urban setting: a cross-sectional study in Nairobi City County, Kenya

Effective coverage requires that those in need can access skilled care supported by adequate resources. There are, however, few studies of effective coverage of facility-based neonatal care in low-income settings, despite the recognition that improving newborn survival is a global priority.We used a detailed retrospective review of medical records for neonatal admissions to public, private not-for-profit (mission) and private-for-profit (private) sector facilities providing 24×7 inpatient neonatal care in Nairobi City County to estimate the proportion of small and sick newborns receiving nationally recommended care across six process domains. We used our findings to explore the relationship between facility measures of structure and process and estimate effective coverage.Of 33 eligible facilities, 28 (four public, six mission and 18 private), providing an estimated 98.7% of inpatient neonatal care in the county, agreed to partake. Data from 1184 admission episodes were collected. Overall performance was lowest (weighted mean score 0.35 [95% confidence interval or CI: 0.22-0.48] out of 1) for correct prescription of fluid and feed volumes and best (0.86 [95% CI: 0.80-0.93]) for documentation of demographic characteristics. Doses of gentamicin, when prescribed, were at least 20% higher than recommended in 11.7% cases. Larger (often public) facilities tended to have higher process and structural quality scores compared with smaller, predominantly private, facilities. We estimate effective coverage to be 25% (estimate range: 21-31%). These newborns received high-quality inpatient care, while almost half (44.5%) of newborns needed care but did not receive it and a further 30.4% of newborns received an inadequate service.Failure to receive services and gaps in quality of care both contribute to a shortfall in effective coverage in Nairobi City County. Three-quarters of small and sick newborns do not have access to high-quality facility-based care. Substantial improvements in effective coverage will be required to tackle high neonatal mortality in this urban setting with high levels of poverty

Nursing knowledge of essential maternal and newborn care in a high‐mortality urban African setting: A cross‐sectional study

Aims To assess the knowledge of nurses of national guidelines for emergency maternity, routine newborn and small and sick newborn care in Nairobi County, Kenya. Background The vast majority of women deliver in a health facility in Nairobi. Yet, maternal and neonatal mortality remain high. Ensuring competency of health workers, in providing essential maternal and newborn interventions in health facilities will be key if further progress is to be made in reducing maternal and neonatal mortality in low‐resource settings. Design Cross‐sectional survey. Methods Questionnaires comprised of clinical vignettes and direct questions and were administered in 2015–2016 to nurses (n = 125 in 31 facilities) on duty in maternity and newborn units in public and private facilities providing 24/7 inpatient neonatal services. Composite knowledge scores were calculated and presented as weighted means. Associations were explored using regression. STROBE guidelines were followed. Results Nurses scored best for knowledge on active management of the mother after birth and immediate routine newborn care. Performance was worst for questions on infant resuscitation, checking signs and symptoms of sick newborns, and managing hypertension in pregnancy. Overall knowledge of care for sick newborns was particularly low (score 0.62 of 1). Across all areas assessed, nurses who had received training since qualifying performed better than those who had not. Poorly resourced and low case‐load facilities had lower average knowledge scores compared with better‐resourced and busier facilities. Conclusion Overall, we estimate that 31% of maternity patients, 3% of newborns and 39% of small and sick newborns are being cared for in an environment where nursing knowledge is very low (score <0.6). Relevance to clinical practice Focus on periodic training, ensuring retention of knowledge and skills among health workers in low‐case load setting, and bridging the know‐do gap may help to improve the quality of care delivered to mothers and newborns in Kenya

Do the feeding practices and nutrition status among HIV-exposed infants less than 6 months of age follow the recommended guidelines in Bomet County, Kenya?

BACKGROUND: Globally, about 1.5 million pregnancies are among women living with the Human Immuno-deficiency Virus (HIV). In 2013, an estimated overall HIV prevalence of 0.34 % was reported in antenatal women in Kenya, with 13,000 new HIV infections among children. Appropriate feeding practices and good nutrition status are important for the survival, growth, development and health of HIV-exposed infants, as well as the wellbeing of their mothers. The purpose of this study was to determine the feeding practices and nutrition status of HIV-exposed infants 0–5 months of age, attending the paediatric clinic in a mission hospital in Bomet County, Kenya. METHODS: This was a cross-sectional study with quantitative and qualitative techniques in data collection and analysis. A comprehensive sample of 118 mothers/caregivers with HIV-exposed infants 0–5 months of age participated in the study. The data was analysed using SPSS software. Statistical significance was set at p values less than 0.05. RESULTS: Exclusive breastfeeding was practiced by the majority of the participants (73.7 %), 14.4 % practiced exclusive replacement feeding and 11.9 % mixed fed their infants. More than half the infants had normal length for age (57.7 %), weight for age (60.2 %) and weight for length (76.3 %). About a third (38.1 %) of the infants were stunted, 39 % were underweight and 19.5 % were wasted. Infants on mixed feeding were more likely to be stunted (OR = 2.401; 95 % CI: 0.906–5.806; p = 0.001) or underweight (OR = 2.001; 95 % CI: 0.328–6.124; p = 0.001) compared to those on exclusive breastfeeding. There was however, no significant difference in the likelihood for wasting among infants on exclusive breastfeeding, compared to those on exclusive replacement feeding (OR = 0.186; 95 % CI: 0.011–3.130; p = 0.996) or mixed feeding (OR = 1.528; 95 % CI: 0.294–7.954; p = 0.614). No significant differences were observed in the likelihood for malnutrition among infants on exclusive breastfeeding, compared to those on exclusive replacement feeding. CONCLUSION: Most mothers/caregivers fed their infants as recommended. The 11.9 % who did not observe the recommendations were however, at risk for contracting HIV. We recommend that the Ministry of Health and National AIDS and STI Control Programme develop a policy to support infants who qualify for exclusive replacement feeding but whose mothers/caregivers face constraints in compliance

Nursing knowledge of essential maternal and newborn care in a high‐mortality urban African setting: A cross‐sectional study

Aims To assess the knowledge of nurses of national guidelines for emergency maternity, routine newborn and small and sick newborn care in Nairobi County, Kenya. Background The vast majority of women deliver in a health facility in Nairobi. Yet, maternal and neonatal mortality remain high. Ensuring competency of health workers, in providing essential maternal and newborn interventions in health facilities will be key if further progress is to be made in reducing maternal and neonatal mortality in low‐resource settings. Design Cross‐sectional survey. Methods Questionnaires comprised of clinical vignettes and direct questions and were administered in 2015–2016 to nurses (n = 125 in 31 facilities) on duty in maternity and newborn units in public and private facilities providing 24/7 inpatient neonatal services. Composite knowledge scores were calculated and presented as weighted means. Associations were explored using regression. STROBE guidelines were followed. Results Nurses scored best for knowledge on active management of the mother after birth and immediate routine newborn care. Performance was worst for questions on infant resuscitation, checking signs and symptoms of sick newborns, and managing hypertension in pregnancy. Overall knowledge of care for sick newborns was particularly low (score 0.62 of 1). Across all areas assessed, nurses who had received training since qualifying performed better than those who had not. Poorly resourced and low case‐load facilities had lower average knowledge scores compared with better‐resourced and busier facilities. Conclusion Overall, we estimate that 31% of maternity patients, 3% of newborns and 39% of small and sick newborns are being cared for in an environment where nursing knowledge is very low (score <0.6). Relevance to clinical practice Focus on periodic training, ensuring retention of knowledge and skills among health workers in low‐case load setting, and bridging the know‐do gap may help to improve the quality of care delivered to mothers and newborns in Kenya