Salmonella ovarian abscess in a patient with systemic lupus erythematosus presented as acute abdomen: A case report and review of the literature

A Salmonella ovarian abscess is a rare entity, and is similarly uncommon in cases with Systemic Lupus Erythematosus. To the best of our knowledge, thirty four cases of Salmonella ovarian abscess have been published in the literature, and only four of them were related to Systemic Lupus Eritematosus. Our aim is to review this clinical entity using information from our own experience as well as that from published cases. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved

The Status of Antioxidants and Oxidative Damage in Patients with COVID-19

Purpose: COVID-19 is a viral disease that has recently caused a pandemic and significantly affects human health. In this study, superoxide dismutase, glutathione peroxidase, glutathione, total thiol, natural thiol, disulfide, oxidative DNA damage and malondialdehyde levels in COVID-19 were investigated. Materials and Methods: Thirty-five patients and 35 healthy volunteers were included in this study. The diagnosis of COVID-19 was made by reverse transcriptase-polymerase chain reaction. Serum glutathione, glutathione peroxidase, superoxide dismutase, natural thiol, total thiol and disulphide levels by enzyme-linked immunosorbent assay and malondialdehyde and 8-hydroxy-2-deoxyguanosine/10⁶ deoxyguanosine levels by high-pressure liquid chromatography measured. Results: While serum superoxide dismutase, glutathione peroxidase, malondialdehyde, 8-hydroxy-2-deoxyguanosine/10⁶ deoxyguanosine, disulfide levels were higher in the COVID-19 patient group than in the healthy control group, glutathione, total thiol, natural thiol levels were lower. In addition, there was a negative correlation between 8-hydroxy-2-deoxyguanosine/10⁶ deoxyguanosine and glutathione, natural thiol and total thiol, and a positive correlation with disulfide. Conclusion: This study revealed that serum superoxide dismutase, glutathione peroxidase, malondialdehyde, 8-hydroxy-2-deoxyguanosine/10⁶ deoxyguanosine, and disulfide levels increased and glutathione, thiol and natural thiol levels decreased in COVID-19 patients. These results revealed that there was a decrease in antioxidant marker levels and an increase in oxidative stress markers in COVID-19 patients

A Case Of Brucellosis Lymphadenitis Mimicking Scrofuloderma

Brucellosis is a zoonotic disease, which may be manifested by multisystemic involvement. While the complications related to musculoskeletal and gastrointestinal system are frequently seen, those related to the other systems are rarely encountered. In this paper, we present a brucellosis lymphadenitis case in the right side of the neck in a 20 years old female patient, presenting with a mass formation in the soft tissue mimicking scrofuloderma, with dimensions of 10x6x4 cm. Especially in endemic areas, brucellosis lymphadenitis should also be remembered in addition to scrofuloderm

Weil’s Disease: A Case Report

Leptospirosis is a widespread zoonosis manifesting itself in various types all over the world. A 23-yearold male patient, who referred to the Emergency Unit of Yüzüncü Y›l University Medical Faculty, suffered from fever, sweats, anorexia, fatigue, headache, myalgia, hiccups, nausea and vomiting, oliguria and darkening of the urine beginning 15 days before. Leptospiras were seen by dark field examination of the preparations from urine samples of the patient that we were informed to be a building worker in Istanbul. In the serum samples taken from pre-treatment period, we have found a positiveness against Leptospira icterohaemorrhagiae Wijnberg strain at a titer of 1/3200 by method of microscopic agglutination test (MAT) in Etlik Veterinary Control and Investigation Institute. The patient who was determined to have acute renal failure and hepatic function disorder was discharged from the hospital after treatment with a complete recovery

Comparison of colistin-carbapenem, colistin-sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections

23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) -- 41394 -- Berlin, GERMANYWOS: 000338723600006PubMed ID: 24532009The purpose of this investigation was to compare the efficacy of colistin-based therapies in extremely drug-resistant Acinetobacter spp. bloodstream infections (XDR-ABSI). A retrospective study was conducted in 27 tertiary-care centers from January 2009 to August 2012. The primary end-point was 14-day survival, and the secondary end-points were clinical and microbiological outcomes. Thirty-six and 214 patients [102 (47.7 %): colistin-carbapenem (CC), 69 (32.2 %): colistin-sulbactam (CS), and 43 (20.1 %: tigecycline): colistin with other agent (CO)] received colistin monotherapy and colistin-based combinations, respectively. Rates of complete response/cure and 14-day survival were relatively higher, and microbiological eradication was significantly higher in the combination group. Also, the in-hospital mortality rate was significantly lower in the combination group. No significant difference was found in the clinical (p = 0.97) and microbiological (p = 0.92) outcomes and 14-day survival rates (p = 0.79) between the three combination groups. Neither the timing of initial effective treatment nor the presence of any concomitant infection was significant between the three groups (p > 0.05) and also for 14-day survival (p > 0.05). Higher Pitt bacteremia score (PBS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Charlson comorbidity index (CCI), and prolonged hospital and intensive care unit (ICU) stay before XDR-ABSI were significant risk factors for 14-day mortality (p = 0.02, p = 0.0001, p = 0.0001, p = 0.02, and p = 0.01, respectively). In the multivariable analysis, PBS, age, and duration of ICU stay were independent risk factors for 14-day mortality (p < 0.0001, p < 0.0001, and p = 0.001, respectively). Colistin-based combination therapy resulted in significantly higher microbiological eradication rates, relatively higher cure and 14-day survival rates, and lower in-hospital mortality compared to colistin monotherapy. CC, CS, and CO combinations for XDR-ABSI did not reveal significant differences with respect to 14-day survival and clinical or microbiological outcome before and after propensity score matching (PSM). PBS, age, and length of ICU stay were independent risk factors for 14-day mortality

Miego apnėja tarp sergančiųjų išemine širdies liga: dažnis, susiję veiksniai, sąsajos su kairiojo skilvelio morfometrijos ir funkcijos rodikliais

The purpose of the study. The purpose of this cross sectional study was to determine prevalence of sleep apnea, characteristics, association with traditional CAD risk factors and to investigate association between sleep apnea and alteration in left ven-tricular morphometry and function in CAD patients. Objectives of the study. 1. To cross-sectionally investigate prevalence of sleep apnea and differ-ences in clinical and polysomnographic characteristics in CAD pa-tients with and without sleep apnea. 2. To explore whether routine clinical features from the study of patients with CAD could predict the presence of sleep apnea by two thresholds for diagnosing (apnea-hyponea index ≥5 and ≥15). 3. To determine whether there are differences in risk factors for the pres-ence of sleep apnea between men and women with CAD. 4. To cross-sectionally investigate the association between sleep apnea and left ventricular morphometry in CAD patients. 5. To identify association between left ventricular diastolic function pa rameters and sleep apnea in CAD patients with left ventricular ejec-tion fraction ≥50%. Statements of the hypotheses. We hypothesised, that in CAD patients: 1. Sleep apnea is common in CAD patients with no previous sleep apnea diagnosis. The traditional CAD risk factors such as age, male gender, obesity and hypertension, is more prevalent among patients with sleep apnea compared with patients without sleep apnea. Significant small correlations between some polisomnographic parameters and the severity of sleep apnea could be found. 2. Using the same set of potential clinical confounders, the prognostic factors of the presence of sleep apnea differ when adapting the two cutoffs of apnea-hypopnea index for sleep apnea diagnosis. 3. The risk factors for the presence of SA in women differ from those in men. 4. Mild to moderate sleep apnea is cross-sectionally [...]

Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study

Objective Neuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes