Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation.

ObjectiveProton magnetic resonance spectroscopy (1H MRS) in opiate dependence showed abnormalities in neuronal viability and glutamate concentration in the anterior cingulate cortex (ACC). Metabolite levels in dorsolateral prefrontal cortex (DLPFC) or orbitofrontal cortex (OFC) and their neuropsychological correlates have not been investigated in opiate dependence.MethodsSingle-volume proton MRS at 4 Tesla and neuropsychological testing were conducted in 21 opiate-dependent individuals (OD) on buprenorphine maintenance therapy. Results were compared to 28 controls (CON) and 35 alcohol-dependent individuals (ALC), commonly investigated treatment-seekers providing context for OD evaluation. Metabolite concentrations were measured from ACC, DLPFC, OFC and parieto-occipital cortical (POC) regions.ResultsCompared to CON, OD had lower concentrations of N-acetylaspartate (NAA), glutamate (Glu), creatine +phosphocreatine (Cr) and myo-Inositol (mI) in the DLPFC and lower NAA, Cr, and mI in the ACC. OD, ALC, and CON were equivalent on metabolite levels in the POC and γ-aminobutyric acid (GABA) concentration did not differ between groups in any region. In OD, prefrontal metabolite deficits in ACC Glu as well as DLPFC NAA and choline containing metabolites (Cho) correlated with poorer working memory, executive and visuospatial functioning; metabolite deficits in DLPFC Glu and ACC GABA and Cr correlated with substance use measures. In the OFC of OD, Glu and choline-containing metabolites were elevated and lower Cr concentration related to higher nonplanning impulsivity. Compared to 3 week abstinent ALC, OD had significant DLPFC metabolite deficits.ConclusionThe anterior frontal metabolite profile of OD differed significantly from that of CON and ALC. The frontal lobe metabolite abnormalities in OD and their neuropsychological correlates may play a role in treatment outcome and could be explored as specific targets for improved OD treatment

The Nature of the UV/X-Ray Absorber in PG 2302+029

We present Chandra X-ray observations of the radio-quiet QSO PG 2302+029. This quasar has a rare system of ultra-high velocity (-56,000 km/s) UV absorption lines that form in an outflow from the active nucleus (Jannuzi et al. 2003). The Chandra data indicate that soft X-ray absorption is also present. We perform a joint UV and X-ray analysis, using photoionization calculations, to detemine the nature of the absorbing gas. The UV and X-ray datasets were not obtained simultaneously. Nonetheless, our analysis suggests that the X-ray absorption occurs at high velocities in the same general region as the UV absorber. There are not enough constraints to rule out multi-zone models. In fact, the distinct broad and narrow UV line profiles clearly indicate that multiple zones are present. Our preferred estimates of the ionization and total column density in the X-ray absorber (log U=1.6, N_H=10^22.4 cm^-2) over predict the O VI 1032, 1038 absorption unless the X-ray absorber is also outflowing at ~56,000 km/s, but they over predict the Ne VIII 770, 780 absorption at all velocities. If we assume that the X-ray absorbing gas is outflowing at the same velocity of the UV-absorbing wind and that the wind is radiatively accelerated, then the outflow must be launched at a radius of < 10^15 cm from the central continuum source. The smallness of this radius casts doubts on the assumption of radiative acceleration.Comment: Accepted for Publication in Ap

Antibody-Based Immunotherapy of Cancer

By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss these innovative strategies and propose how they will impact the future of antibody-based cancer therapy

A semantic Grid for molecular science

Proceedings of the 2003 UK e-Science All Hands Meeting, 31st August - 3rd September, Nottingham UKThe properties of molecules have very well defined semantics and allow the creation of a semantic GRID. Markup languages (CML - Chemical Markup Language) and dictionary-based ontologies have been designed to support a wide range of applications, including chemical supply, publication and the safety of compounds. Many properties can be computed by Quantum Mechanical (QM) programs and we have developed a "black-box" system based on XML wrappers for all components. This is installed on a Condor system on which we have computed properties for 250, 000 compounds. The results of this will be available in an OpenData/OpenSource peer-to-peer (P2P) system (WorldWide Molecular Matrix - WWMM)

Corporate Takeovers: Who Wins; Who Loses; Who Should Regulate

On December 3, 1987, during its 11th Annual Policy Conference in Washington, DC, the American Enterprise Institute convened a panel discussion on Corporate Takeovers and Insider Trading: Who Should Regulate? The panelists were John C. Coffee, Jr., professor of law at Columbia University; Joseph A. Grundfest, commissioner at the Securities and Exchange Commission; Roberta Romano, professor of law at Yale Law School; and Murray L. Weidenbaum, Mallinckrodt Distinguished University Professor and director of the Center for the Study of American Business at Washington University. The panel was moderated by Christopher C. DeMuth, president of AEI. The following discussion is drawn from these proceedings

A COMPARISON OF RESISTED AND ASSISTED SPRINT TRAINING IN COLLEGIATE SPRINTERS

Sprint time (ST) is the product of stride length (SL) and stride rate (SR). Increases in either of these variables results in speed improvement. Purpose:  To compare resisted (RST) and assisted sprint training (AST) on sprint performance. Methods:  Twenty (10 male, 10 female) collegiate sprinters and hurdlers were randomly divided into two training groups: RST (age: 21.8±1.8yrs, height: 1.73±0.10m, mass: 69.5±12.8kg) and AST (age: 22.2±2.4yrs, height: 1.76±0.10m, mass: 69.1±9.9kg). Each group trained 3 days/week for 6 weeks. The RST group used a combination of weighted sled pulls, uphill sprinting and depth jumps. The AST group combined downhill running, towing, sprint ladders and single leg bounds. Prior to and following the training interventions SL and ST (10 meter sprint time) were recorded at sprint distances of 30m, 60m, and 120m during the last 10 meters of each sprint distance. Pre-post training ST and SL were compared within training groups at each sprint distance using paired t-tests. Additionally, a gain score was calculated by taking the difference between the post and pre test scores. The gain scores for SL and ST were compared between training groups via independent t-tests at each sprint distance. Results: For the RST 30m, ST (1.18±0.08s vs 1.14±0.08s, p&lt;0.01) and SL (2.06±0.08m vs. 2.09±1.14m, p&lt;0.01) were significantly improved. For the AST, 30m ST (1.19±0.08s vs. 1.18±0.08s, p&lt;0.01) and SL (2.10±0.13m vs. 2.11±0.13, p=0.04) were significantly improved. No improvements in ST or SL were detected for either the RST or AST groups at the 60m sprint distance. For the RST 120m, ST (1.13±0.07s vs. 1.12±0.08s, p&lt;0.01) was significantly improved. For the AST 120m, ST (1.12±0.07s vs. 1.11±0.07s, p&lt;0.01) and SL (2.30±0.08 vs. 2.33±0.08, p&lt;0.01) were significantly improved. At the 30M interval, the RST demonstrated significant improvements in SL and ST as compared to the AST (p&lt;0.01). However, at the 120M interval, the AST demonstrated a significant improvement in SL as compared to the RST (p&lt;0.01). Conclusion: Within the parameters of this study, RST and AST methods have proven effective at improving sprint performance. It appears that RST protocols may be of greatest benefit for improving sprint performance at shorter distances, while AST protocols may be of greater benefit at longer sprinting distances.  Article visualizations

Dynamics of the Sharp Edges of Broad Planetary Rings

(Abridged) The following describes a model of a broad planetary ring whose sharp edge is confined by a satellite's m^th Lindblad resonance (LR). This model uses a streamline formalism to calculate the ring's internal forces, namely, ring gravity, pressure, viscosity, as well as a hypothetical drag force. The model calculates the streamlines' forced orbit elements and surface density throughout the perturbed ring. The model is then applied to the outer edge of Saturn's B ring, which is maintained by an m=2 inner LR with the satellite Mimas. Ring models are used to illustrate how a ring's perturbed state depends on the ring's physical properties: surface density, viscosity, dispersion velocity, and the hypothetical drag force. A comparison of models to the observed outer B ring suggests that the ring's surface density there is between 10 and 280 gm/cm^2. The ring's edge also indicates where the viscous torque counterbalances the perturbing satellite's gravitational torque on the ring. But an examination of seemingly conventional viscous B ring models shows that they all fail to balance these torques at the ring's edge. This is due ring self-gravity and the fact that a viscous ring tends to be nearly peri-aligned with the satellite, which reduces the satellite's torque on the ring and makes the ring's edge more difficult to maintain. Nonetheless, the following shows that a torque balance can still be achieved in a viscous B ring, but only in an extreme case where the ratio of the ring's bulk/shear viscosities satisfy ~10^4. However, if the dissipation of the ring's forced motions is instead dominated by a weak drag force, then the satellite can exert a much stronger torque that can counterbalance the ring's viscous torque.Comment: Accepted for publication in the Astrophysical Journal on April 3, 200