110 research outputs found
Synthesis and magnetic properties of a copper cube : [Cu4(OH)4(C16H18N2)4]4+ (ClO4)4 C3H6O [C16H18N2 = (E)-1,6-[di(pyridin-4-yl)hex-3-ene
We are grateful to the National Mass Spectrometry Service Center for mass spectra and to the UK National Crystallography Service for data sets. Supplementary Figure S1-S4: IR and UV/Vis spectra of compound 1Peer reviewedPublisher PD
Effectiveness of a training program for police officers who come into contact with people with mental health problems : A pragmatic randomised controlled trial
INTRODUCTION: Police officers frequently come into contact with individuals with mental health problems. Specialist training in this area for police officers may improve how they respond to individuals with mental health problems; however, evidence to support this is sparse. This study evaluated the effectiveness of one bespoke mental health training package for frontline police officers relative to routine training. DESIGN: Pragmatic, two-armed cluster randomised controlled trial in one police force in England. Police stations in North Yorkshire were randomised with frontline police officers receiving either a bespoke mental health training package or routine training. The primary outcome was the number of incidents which resulted in a police response reported to the North Yorkshire Police control room up to six months after delivery of training. Secondary outcomes included: likelihood of incidents using Section 136 of the Mental Health Act; likelihood of incidents having a mental health tag applied; and number of individuals with a mental health warning marker involved in incidents. The appropriateness of mental health tags applied to a random sample of incidents was checked by an independent mental health professional. Routinely collected data were used. RESULTS: Twelve police stations were recruited and randomised (Intervention group n = 6; Control group n = 6), and 249 officers received the bespoke mental health training intervention. At follow-up, a median of 397 incidents were assigned to trial stations in the intervention group, and 498 in the control group. There was no evidence of a difference in the number of incidents with a police response (adjusted incidence rate ratio (IRR) 0.92, 95% CI 0.61 to 1.38, p = 0.69), or in the number of people with mental health warning markers involved in incidents (adjusted IRR 1.39, 95% CI 0.91 to 2.10, p = 0.13) between the intervention and control groups up to six months following the intervention; however, incidents assigned to stations in the intervention group were more likely to have a mental health tag applied to them than incidents assigned to control stations (adjusted odds ratio 1.41, 95% CI 1.16 to 1.71, p = 0.001). The review of 100 incidents suggests that there may be incidents involving individuals with mental health issues that are not being recorded as such (Kappa coefficient 0.65). There was no statistically significant difference in the likelihood of Section 136 of the Mental Health Act being applied to an incident. CONCLUSIONS: The bespoke one day mental health training delivered to frontline officers by mental health professionals did not reduce the number of incidents reported to the police control room up to six months after its delivery; however training may have a positive effect on how the police record incidents involving individuals with mental health problems. Our trial has shown that conducting pragmatic trials within the police setting is feasible and acceptable. There is a wealth of routinely collected police data that can be utilised for research and further collaboration between police forces and academia is encouraged. TRIAL REGISTRATION: ISRCTN (ISRCTN11685602). The authors confirm that all ongoing and related trials for this drug/intervention are registered
SPECULOOS Northern Observatory: Searching for Red Worlds in the Northern Skies
peer reviewedSPECULOOS is a ground-based transit survey consisting of six identical 1 m robotic telescopes. The immediate goal of the project is to detect temperate terrestrial planets transiting nearby ultracool dwarfs (late M-dwarf stars and brown dwarfs), which could be amenable for atmospheric research with the next generation of telescopes. Here, we report the developments of the northern counterpart of the project-SPECULOOS Northern Observatory, and present its performance during the first three years of operations from mid-2019 to mid-2022. Currently, the observatory consists of one telescope, which is named Artemis. The Artemis telescope demonstrates remarkable photometric precision, allowing it to be ready to detect new transiting terrestrial exoplanets around ultracool dwarfs. Over the period of the first three years after the installation, we observed 96 objects from the SPECULOOS target list for 6000 hr with a typical photometric precision of 0.5%, and reaching a precision of 0.2% for relatively bright non-variable targets with a typical exposure time of 25 s. Our weather downtime (clouds, high wind speed, high humidity, precipitation and/or high concentration of dust particles in the air) over the period of three years was 30% of overall night time. Our actual downtime is 40% because of additional time loss associated with technical problems
Zoledronate in the prevention of Paget's (ZiPP): Protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget's disease of bone
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n = 152) and 3, 311 controls, and 67 CBD cases and 439 controls in a replication stage. Associations with meta-analysis were 17q21 at MAPT (P = 1.42 x 10(-12)),8p12 at lnc-KIF13B-1, a long non-coding RNA (rs643472;P = 3.41 x 10(-8)),and 2p22 at SOS1 (rs963731;P = 1.76 x 10(-7)). Testing for association of CBD with top progressive supranuclear palsy (PSP) GWAS single-nucleotide polymorphisms (SNPs) identified associations at MOBP (3p22;rs1768208;P = 2.07 x 10(-7)) and MAPT H1c (17q21;rs242557;P = 7.91 x 10(-6)). We previously reported SNP/transcript level associations with rs8070723/MAPT, rs242557/MAPT, and rs1768208/MOBP and herein identified association with rs963731/SOS1. We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein)
A roadmap to the efficient and robust characterization of temperate terrestrial planet atmospheres with JWST
Ultra-cool dwarf stars are abundant, long-lived, and uniquely suited to
enable the atmospheric study of transiting terrestrial companions with JWST.
Amongst them, the most prominent is the M8.5V star TRAPPIST-1 and its seven
planets, which have been the favored targets of eight JWST Cycle 1 programs.
While Cycle 1 observations have started to yield preliminary insights into the
planets, they have also revealed that their atmospheric exploration requires a
better understanding of their host star. Here, we propose a roadmap to
characterize the TRAPPIST-1 system -- and others like it -- in an efficient and
robust manner. We notably recommend that -- although more challenging to
schedule -- multi-transit windows be prioritized to constrain stellar
heterogeneities and gather up to 2 more transits per JWST hour spent.
We conclude that in such systems planets cannot be studied in isolation by
small programs, thus large-scale community-supported programs should be
supported to enable the efficient and robust exploration of terrestrial
exoplanets in the JWST era
Early Release Science of the exoplanet WASP-39b with JWST NIRISS
Transmission spectroscopy provides insight into the atmospheric properties
and consequently the formation history, physics, and chemistry of transiting
exoplanets. However, obtaining precise inferences of atmospheric properties
from transmission spectra requires simultaneously measuring the strength and
shape of multiple spectral absorption features from a wide range of chemical
species. This has been challenging given the precision and wavelength coverage
of previous observatories. Here, we present the transmission spectrum of the
Saturn-mass exoplanet WASP-39b obtained using the SOSS mode of the NIRISS
instrument on the JWST. This spectrum spans m in wavelength and
reveals multiple water absorption bands, the potassium resonance doublet, as
well as signatures of clouds. The precision and broad wavelength coverage of
NIRISS-SOSS allows us to break model degeneracies between cloud properties and
the atmospheric composition of WASP-39b, favoring a heavy element enhancement
("metallicity") of the solar value, a sub-solar
carbon-to-oxygen (C/O) ratio, and a solar-to-super-solar potassium-to-oxygen
(K/O) ratio. The observations are best explained by wavelength-dependent,
non-gray clouds with inhomogeneous coverage of the planet's terminator.Comment: 48 pages, 12 figures, 2 tables. Under review at Natur
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