Balancing on a razor's edge: running the radical feminist lesbian Onlywomen Press

This article follows the story of Onlywomen Press as told from the archives they created, which are now available in the Women’s Library at LSE. Onlywomen Press was Britain’s first radical feminist lesbian printing and publishing company. Founded in 1974, the press had two aims: to publish lesbian women’s writing and to enable women to control the print production process itself. Being part of the women’s liberation movement meant not only recognizing their oppression but also opting out of the mechanisms that supported that oppression and creating new ways of working. This article will show that while their vision remained constant, it was extremely difficult to achieve and remain financially solvent

6 items to discover in LSE Library exhibition ‘Making modern women: women’s magazines in interwar Britain’

The new LSE Library online exhibition Making Modern Women: Women’s Magazines in Interwar Britain highlights the complexity of magazines produced by women for women readers between the two World Wars and the different notions of ‘modern women’ they suggest. In this blog post, curator Dr Gillian Murphy introduces six items from Making Modern Women. Taken collectively, the examples show the richness and diversity of genres addressed to women readers, offering them a new world of opportunities, as wives and mothers, as active, global citizens and as wage-earners

Evaluation of a digital consultation and self-care advice tool in primary care: a multi-methods study

Digital services are often regarded as a solution to the growing demands on primary care services. Provision of a tool offering advice to support self-management as well as the ability to digitally consult with a General Practitioner (GP) has the potential to alleviate some of the pressure on primary care. This paper reports on a Phase II, 6-month evaluation of eConsult, a web-based triage and consultation system that was piloted across 11 GP practices across Scotland. Through a multi-method approach the evaluation explored eConsult use across practices, exposing both barriers and facilitators to its adoption. Findings suggest that expectations that eConsult would offer an additional and alternative method of accessing GP services were largely met. However, there is less certainty that it has fulfilled expectations of promoting self-help. In addition, low uptake meant that evaluation of current effectiveness was difficult for practices to quantify. The presence of an eConsult champion(s) within the practice was seen to be a significant factor in ensuring successful integration of the tool. A lack of patient and staff engagement, insufficient support and lack of protocols around processes were seen as barriers to its success

Extracellular regulation of metalloproteinases

Matrix metalloproteinases (MMPs) and adamalysin-like metalloproteinase with thrombospondin motifs (ADAMTSs) belong to the metzincin superfamily of metalloproteinases and they play key roles in extracellular matrix catabolism, activation and inactivation of cytokines, chemokines, growth factors, and other proteinases at the cell surface and within the extracellular matrix. Their activities are tightly regulated in a number of ways, such as transcriptional regulation, proteolytic activation and interaction with tissue inhibitors of metalloproteinases (TIMPs). Here, we highlight recent studies that have illustrated novel mechanisms regulating the extracellular activity of these enzymes. These include allosteric activation of metalloproteinases by molecules that bind outside the active site, modulation of location and activity by interaction with cell surface and extracellular matrix molecules, and endocytic clearance from the extracellular milieu by low-density lipoprotein receptor-related protein 1 (LRP1)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5 antibody 1B7 that blocks LRP1-mediated internalization without affecting the aggrecanolytic activity. Addition of 1B7 to cultured human chondrocytes revealed the full aggrecanolytic activity of ADAMTS-5 generated by the cells. 1B7 is a useful tool to estimate the ADAMTS-5 activity and to identify its potential roles in the tissues

The Perfect Coffee Cup

To design a coffee cup that will maintain the coffee at the optimal drinking temperature for several hours using Phase Change Material, PCM. The importance of this project is designing a coffee cup that will retain its temperature for a prolonged period of time giving the consumer plenty of time to finish their coffee at the desired consumption temperature. We designed a double walled cup that would contain the PCM. Heat transfer calculations were done for different materials such as acrylic, glass, and stainless steel with various thicknesses for each material. These calculations were used to decide on the ideal material the cup should be made out of and the optimum thickness of the material. Rigorous experimentations have been done with the PCM showing the relationship between temperature and time for both melting and cooling the PCM. These experimentations were used to determine the amount of PCM needed per volume of coffee. Based off the preliminary heat transfer calculations, material pricing and availability, it has been concluded to manufacture the cup out of either glass or acrylic for the best results. Once the coffee is poured into the cup, the PCM will begin to melt, immediately activating the PCM. This will instantly cool the coffee to the optimal drinking temperature of 60°C and maintain the temperature of the coffee around 60°C for several hours. We anticipate that the PCM will be able to keep the coffee hot for at least twice as long while, cooling the coffee to drinking temperature in minutes. The PCM will melt at 60°C and will absorb the heat until the temperature of the coffee drops below 60°C. When this happens the PCM will then begin to solidify and radiate heat to warm the coffee back up to optimal temperatures.https://scholarscompass.vcu.edu/capstone/1050/thumbnail.jp

Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells

Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to address the mechanism of TIMP-3-driven apoptosis in human VSMCs we find that TIMP-3 increased activation of caspase-8 and apoptosis was inhibited by expression of Cytokine response modifier A (CrmA) and dominant negative FAS-Associated protein with Death Domain (FADD). TIMP-3 induced apoptosis did not cause mitochondrial depolarisation, increase activation of caspase-9 and was not inhibited by over-expression of B-cell Lymphoma 2 (Bcl2), indicating a mitochondrial independent/type-I death receptor pathway. TIMP-3 increased levels of the First Apoptosis Signal receptor (FAS) and depletion of FAS with shRNA showed TIMP-3-induced apoptosis was FAS dependent. TIMP-3 induced formation of the Death-Inducing Signalling Complex (DISC), as detected by immunoprecipitation and by immunofluorescence. Cellular-FADD-like IL-1 converting enzyme-Like Inhibitory Protein (c-FLIP) localised with FAS at the cell periphery in the absence of TIMP-3 and this localisation was lost on TIMP-3 expression with c-FLIP adopting a perinuclear localisation. Although TIMP-3 inhibited FAS shedding, this did not increase total surface levels of FAS but instead increased FAS levels within localised regions at the cell surface. A Disintegrin And Metalloproteinase 17 (ADAM17) is inhibited by TIMP-3 and depletion of ADAM17 with shRNA significantly decreased FAS shedding. However ADAM17 depletion did not induce apoptosis or replicate the effects of TIMP-3 by increasing localised clustering of cell surface FAS. ADAM17-depleted cells could activate caspase-3 when expressing levels of TIMP-3 that were otherwise sub-apoptotic, suggesting a partial role for ADAM17 mediated ectodomain shedding in TIMP-3 mediated apoptosis. We conclude that TIMP-3 induced apoptosis in VSMCs is highly dependent on FAS and is associated with changes in FAS and c-FLIP localisation, but is not solely dependent on shedding of the FAS ectodomain

Twenty years of load theory—Where are we now, and where should we go next?

Selective attention allows us to ignore what is task-irrelevant and focus on what is task-relevant. The cognitive and neural mechanisms that underlie this process are key topics of investigation in cognitive psychology. One of the more prominent theories of attention is perceptual load theory, which suggests that the efficiency of selective attention is dependent on both perceptual and cognitive load. It is now more than 20 years since the proposal of load theory, and it is a good time to evaluate the evidence in support of this influential model. The present article supplements and extends previous reviews (Lavie, Trends in Cognitive Sciences, 9, 75–82. doi:10.​1016/​j.​tics.​2004.​12.​004, 2005, Current Directions in Psychological Science, 19, 143–148. doi:10.​1177/​0963721410370295​, 2010) by examining more recent research in what appears to be a rapidly expanding area. The article comprises five parts, examining (1) evidence for the effects of perceptual load on attention, (2) cognitive load, (3) individual differences under load, (4) alternative theories and criticisms, and (5) the future of load theory. We argue that the key next step for load theory will be the application of the model to real-world tasks. The potential benefits of applied attention research are numerous, and there is tentative evidence that applied research would provide strong support for the theory itself, as well as real-world benefits related to activities in which attention is crucial, such as driving and education

The Grizzly, October 10, 2019

Si, se Puede! Speaker Series Debuts • Charles Rafferty Reads his Brief and Humorous Poems • Highlights from the Annual Security and Fire Safety Report • Meet this Year\u27s Lantern Editor • A Fresh New Look for the Ursinus Website • Opinions: Shane Dawson: YouTube\u27s Savior or Sinner?; More Like Saturday Night Dead, am I Right? • Alumni Give Bears Strengthhttps://digitalcommons.ursinus.edu/grizzlynews/1591/thumbnail.jp