Random projections for Bayesian regression

This article deals with random projections applied as a data reduction technique for Bayesian regression analysis. We show sufficient conditions under which the entire $d$-dimensional distribution is approximately preserved under random projections by reducing the number of data points from $n$ to $k\in O(\operatorname{poly}(d/\varepsilon))$ in the case $n\gg d$. Under mild assumptions, we prove that evaluating a Gaussian likelihood function based on the projected data instead of the original data yields a $(1+O(\varepsilon))$-approximation in terms of the $\ell_2$ Wasserstein distance. Our main result shows that the posterior distribution of Bayesian linear regression is approximated up to a small error depending on only an $\varepsilon$-fraction of its defining parameters. This holds when using arbitrary Gaussian priors or the degenerate case of uniform distributions over $\mathbb{R}^d$ for $\beta$. Our empirical evaluations involve different simulated settings of Bayesian linear regression. Our experiments underline that the proposed method is able to recover the regression model up to small error while considerably reducing the total running time

SSMART: Sequence-structure motif identification for RNA-binding proteins

MOTIVATION: RNA-binding proteins (RBPs) regulate every aspect of RNA metabolism and function. There are hundreds of RBPs encoded in the eukaryotic genomes, and each recognize its RNA targets through a specific mixture of RNA sequence and structure properties. For most RBPs, however, only a primary sequence motif has been determined, while the structure of the binding sites is uncharacterized. RESULTS: We developed SSMART, an RNA motif finder that simultaneously models the primary sequence and the structural properties of the RNA targets sites. The sequence-structure motifs are represented as consensus strings over a degenerate alphabet, extending the IUPAC codes for nucleotides to account for secondary structure preferences. Evaluation on synthetic data showed that SSMART is able to recover both sequence and structure motifs implanted into 3'UTR-like sequences, for various degrees of structured/unstructured binding sites. In addition, we successfully used SSMART on high-throughput in vivo and in vitro data, showing that we not only recover the known sequence motif, but also gain insight into the structural preferences of the RBP. AVAILABILITY: SSMART is freely available at https://ohlerlab.mdc-berlin.de/software/SSMART 137

Effects of Sequence Disorder on DNA Looping and Cyclization

Effects of sequence disorder on looping and cyclization of the double-stranded DNA are studied theoretically. Both random intrinsic curvature and inhomogeneous bending rigidity are found to result in a remarkably wide distribution of cyclization probabilities. For short DNA segments, the range of the distribution reaches several orders of magnitude for even completely random sequences. The ensemble averaged values of the cyclization probability are also calculated, and the connection to the recent experiments is discussed.Comment: 8 pages, 4 figures, LaTeX; accepted to Physical Review E; v2: a substantially revised version; v3: references added, conclusions expanded, minor editorial corrections to the text; v4: a substantially revised and expanded version (total number of pages doubled); v5: new Figure 4, captions expanded, minor editorial improvements to the tex

Distributed Joint Source-Channel Coding With Copula-Function-Based Correlation Modeling for Wireless Sensors Measuring Temperature

Wireless sensor networks (WSNs) deployed for temperature monitoring in indoor environments call for systems that perform efficient compression and reliable transmission of the measurements. This is known to be a challenging problem in such deployments, as highly efficient compression mechanisms impose a high computational cost at the encoder. In this paper, we propose a new distributed joint source-channel coding (DJSCC) solution for this problem. Our design allows for efficient compression and error-resilient transmission, with low computational complexity at the sensor. A new Slepian-Wolf code construction, based on non-systematic Raptor codes, is devised that achieves good performance at short code lengths, which are appropriate for temperature monitoring applications. A key contribution of this paper is a novel Copula-function-based modeling approach that accurately expresses the correlation amongst the temperature readings from colocated sensors. Experimental results using a WSN deployment reveal that, for lossless compression, the proposed Copula-function-based model leads to a notable encoding rate reduction (of up to 17.56%) compared with the state-of-the-art model in the literature. Using the proposed model, our DJSCC system achieves significant rate savings (up to 41.81%) against a baseline system that performs arithmetic entropy encoding of the measurements. Moreover, under channel losses, the transmission rate reduction against the state-of-the-art model reaches 19.64%, which leads to energy savings between 18.68% to 24.36% with respect to the baseline system

A Randomized Parallel Controlled Study of the Efficacy and Safety of Lornoxicam Versus Etoricoxib after Total Knee Arthroplasty

Objectives: The aim of the study was to compare the postoperative analgesic efficacy and safety of lornoxicam versus etoricoxib for the first 48 hours after surgery. Methods: We conducted a prospective randomized controlled study on 110 patients ASAI-II scheduled for TKA under spinal anesthesia, who received either lornoxicam 8 mg PO at the end of surgery and a further 8 mg after 12 hours (Lornoxicam Group) or etoricoxib 120 mg at the end of surgery and one placebo pill after 12 hours (Etoricoxib Group). The primary outcome measure was the cumulative dose of morphine administered during the first postoperative 24 and 48 hours. Secondary outcomes were duration of analgesia and the side effects of the treatment. Results: The groups were similar in terms of demographic data. There are no significant differences between groups regarding the morphine consumption at 24 hours (36.2 ± 12 in Lornoxicam group and 34.5 ± 14.1 in Etoricoxib group) and 48 hours postoperatively (15.6 ± 12.8 in Lornoxicam group and 18 ± 12.3 in Etoricoxib group) or between the duration of analgesia (314.5 ± 70.4 in Lornoxicam group and 320.4 ± 89.2 in Etoricoxib group). Conclusion: Postoperative use of lornoxicam for 48 hours in the dose of 8 mg PO twice a day in patients undergoing TKA has an analgetic effect comparable to etoricoxib 120 mg, fewer patients experienced adverse symptoms in the etoricoxib group, but the difference was not statistically significant

Age-related differences in foot mobility in individuals with patellofemoral pain

Background Age-related changes in midfoot mobility have the potential to influence success with foot orthoses intervention in people with patellofemoral pain (PFP). The aim of this study was to determine whether older people with PFP demonstrate less foot mobility than younger adults with PFP. Methods One hundred ninety four participants (113 (58%) women, age 32 ± 7 years, BMI 25 ± 4.9 kg/m2) with PFP (≥ 6 weeks duration) were included, with foot mobility quantified using reliable and valid methods. K-means cluster analysis classified participants into three homogenous groups based on age. After cluster formation, univariate analyses of co-variance (covariates: sex, weight) were used to compare midfoot height mobility, midfoot width mobility, and foot mobility magnitude between age groups (significance level 0.05). Results Cluster analysis revealed three distinct age groups: 18–29 years (n = 70); 30–39 years (n = 101); and 40–50 years (n = 23). There was a significant main effect for age for midfoot height mobility (p  0.05). Conclusion Individuals with PFP aged 40–50 years have less foot mobility than younger adults with PFP. These findings may have implications for evaluation and treatment of older individuals with PFP

Antioxidant activity in selected tomato genotypes cultivated in conventional and organic culture systems

The present study is a compilation of results obtained at the Vegetable Research and Development Station Bacau regarding the influence of the culture system on the quantitative and qualitative yield of tomatoes. The present study provides comparative information regarding yield achievements of tomato genotypes cultivated in two different culture systems (conventional and organic), in order to highlight the suitability of the cultivation system. The best yield results were obtained at a density of 30,000 plants per hectare in both culture systems. All studied genotypes resulted in quantitatively superior yield in the conventional system as opposed to the organic system. Another purpose of this study was to determine the difference in antioxidant activity of tomato genotypes cultivated in the ecological and the conventional culture systems. The results indicate the suitability of the tomato to organic cultivation, highlighting the potential of the tomato species to be utilized as a significant source of natural antioxidants, and also the influence of cultivation systems on the accumulation of antioxidant compounds.Keywords: Lycopersicon esculentum, polyphenols, flavones, yieldAfrican Journal of Biotechnology Vol. 12(20), pp. 2884-289

Influenţa cultivarului asupra principalilor indici biochimici în seminţele de mazăre

The main biochemical quality indices of seeds for the cultivated plants are influenced by a series of factors, such as: gentic, technological, abiotic or biotic factors. The storage period, the germination capacity and seed vigor are in direct correclation with the seeds’ biochemical indices, which vary depending on the cultivar. The present work presents a study regarding the influence of the cultivar and storage period on the main biochemical indices of the garden pea seeds. The ash content varied in the case of pea seeds between 1.4%for the Skinado cultivar and 2.4% for the Television cultivar. The crude protein varied in the case of the cultivar selection understudy between 20.20% forthe Television cultivar and 27.40% for the Skinado cultivar, and the total lipids varied between 5.10% (Ambrosia cultivar) and 6.50% (Ran 1 round-seedand Kelvedon Wonder cultivars). The reducing sugars varied between quite large limits, from 10.20% in the case of the Television cultivar, up to 18.30% in the case of the Ran 1 wrinkled-seed cultivar

Application of Modern Polymeric Composite Materials in Industrial Construction

The large variety of modern composite materials and products existing nowadays in the construction market provides multiple and convenient possibilities to use them in both structural and nonstructural industrial construction elements. The main advantages of modern composite materials such as: corrosion resistance, high strength and modulus values compared to their density, acceptable deformability, tailored design and excellent formability enable the fabrication of new elements and the structural rehabilitation of the existing parts made of traditional materials. The high potential of the applicability of polymeric composites in new industrial construction correlated with fabrication procedures as well as the use of composites in modern strengthening solutions are presented in the paper