1,350 research outputs found
An intervention tool for use against gender stereotypes in children
This study examines the occurrence of gender stereotyped beliefs and behaviors in young children and methods of intervening against gender stereotypes. Current literature on gender stereotype interventions is reviewed and evaluated. A new model of intervention, based on a coloring book made up of gender counterstereotypic images, is proposed. Implications and limitations are discussed
The lived experience of language (education policy): multimodal accounts by primary school students in Luxembourg
Boston Hospitality Review: Winter 2018
Table of contents: Blockchain Technology & its Implications for the Hospitality Industry By Tarik Dogru, Makarand Mody, & Christie Leonardi -- How Does My Neighbor Feel About my Airbnb? By Makarand Mody, Courtney Suess & Tarik Dogru -- 5 Keys to Successful Hospitality Leadership By Sarah Andersen -- Cutting Through the Online Hospitality Clutter: 10 Best Practices for Organic Visibility By Leora Lanz & Juan Lesmes -- When is a Group a Chain, and a Chain a Brand? By Christopher Muller -- À la Carte Dining in a Banquet Setting: Is it Feasible? By Peter Szende and Ally Run
Which indicators of early cancer diagnosis from population-based data sources are associated with short-term mortality and survival?
BACKGROUND: A key component of recent English cancer policy is the monitoring of trends in early diagnosis of cancer. Early diagnosis can be defined by the disease stage at diagnosis or by other indicators derived from electronic health records. We evaluate the association between different early diagnosis indicators and survival, and discuss the implementation of the indicators in surveillance of early diagnosis. METHODS: We searched the PubMed database and grey literature to identify early diagnosis indicators and evaluate their association with survival. We analysed cancer registrations for 355,502 cancer patients diagnosed in England during the period 2009-2013, and quantified the association between each early diagnosis indicator and 30-day mortality and five-year net survival. RESULTS: Each incremental difference in stage (I-IV) predicts lower 5-year survival, so prognostic information is lost in comparisons which use binary stage indicators. Patients without a recorded stage have high risk of death shortly following diagnosis and lower 5-year survival. Emergency presentation is independently associated with lower five-year survival. Shorter intervals between first symptoms and diagnosis are not consistently associated with improved survival, potentially due to confounding from tumour characteristics. INTERPRETATION: Contrary to current practice, we recommend that all the stage information should be used in surveillance. Patients missing stage should also be included to minimise bias. Combined data on stage and emergency presentation could be used to create summary prognostic measures. More work is needed to create statistics based on the diagnostic interval that will be useful for surveillance
On the Enigmatic Distribution of the Honduran Endemic Leptodactylus silvanimbus (Amphibia: Anura: Lep todactylidae)
Most species of the frog genus Leptodactylus occur in South America, and all authors who have treated the zoogeography of the genus have concluded that it originated somewhere in South America (e.g., Savage 1982). Savage (1982,518) summarized the historical herpetofaunal units of the Neotropics as follows: All evidence points to an ancient contiguity and essential similarity of a generalized tropical herpetofauna that ranged over tropical North, Middle, and most of South America in Cretaceous-Paleocene times. Descendents of this fauna are represented today by the South and Middle American tracks (Elements). To the north of this fauna ranged a subtropical-temperate Laurasian derived unit, today represented by the Old Northern Element (track). By Eocene, northern and southern fragments of the generalized tropical units had become isolated in Middle and South America, respectively. Differentiation in situ until Pliocene produced the distinctive herpetofaunas that became intermixed with the establishment of the Isthmian Link
On the Engimatic Distribution of The Honduran Endemic \u3cem\u3eLeptodactylus Silvanimbus\u3c/em\u3e (Amphibia: Anura: Leptodactylidae)
Most species of the frog genus Leptodactylus occur in South America, and all authors who have treated the zoogeography of the genus have concluded that it originated somewhere in South America (e.g., Savage 1982). Savage (1982, 518) summarized the historical herpetofaunal units of the Neotropics as follows: All evidence points to an ancient contiguity and essential similarity of a generalized tropical herpetofauna that ranged over tropical North, Middle, and most of South America in Cretaceous-Paleocene times. Descendents of this fauna are represented today by the South and Middle American tracks (Elements). To the north of this fauna ranged a subtropical-temperate Laurasian derived unit, today represented by the Old Northern Element (track). By Eocene, northern and southern fragments of the generalized tropical units had become isolated in Middle and South America, respectively. Differentiation in situ until Pliocene produced the distinctive herpetofaunas that became intermixed with the establishment of the Isthmian Link
\u3cem\u3eLeptodactylus silvanimbus\u3c/em\u3e
Adult Leptodactylus silvanimhus are of moderate sized, the head is about as wide as long, and the hind limbs are moderate in length (see Table; also see Heyer and Thompson 2000 for definitions of adult size and leg length categories for Leptodacrylus). The male vocal sac is single and internal. Male forearms are hypertrophied in larger individuals. Adult males have two black thumb spines on each hand and lack chest spines. Individuals lack dorsolateral folds. The toe tips are narrow, not expanded. Females have weakly developed lateral toe fringes and males either have lateral toe ridges or weakly developed fringes. The upper shank surface is shagreened with several dark coni apicales. The outer tarsus has white-tipped tubercles and small dark coni apicales. The sole of the foot is mostly smooth with a few tiny dark coni apicales. The upper lip is gray, paler below and behind the eye. The dorsal pattern is grayish-brown with slightly darker interorbital and middorsal blotches. The species lacks light middorsal stripes. The belly pattern is almost uniform cream. The posterior thigh surfaces are mottled; no individuals have distinct light horizontal stripes on the lower portion of the posterior thigh. The dorsal shank surfaces have irregular dark crossbands
Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa
Infection of susceptible cells by herpes simplex virus (HSV) requires the interaction of the HSV gD glycoprotein with one of two principal entry receptors, herpes virus entry mediator (HVEM) or nectins. HVEM naturally functions in immune signaling, and the gD-HVEM interaction alters innate signaling early after mucosal infection. We investigated whether the gD-HVEM interaction during priming changes lymphocyte recall responses in the murine intravaginal model. Mice were primed with attenuated HSV-2 expressing wild-type gD or mutant gD unable to engage HVEM and challenged 32 days later with virulent HSV-2 expressing wild-type gD. HSV-specific CD8+ T cells were decreased at the genital mucosa during the recall response after priming with virus unable to engage HVEM but did not differ in draining lymph nodes. CD4+ T cells, which are critical for entry of HSV-specific CD8+ T cells into mucosa in acute infection, did not differ between the two groups in either tissue. An inverse association between Foxp3+ CD4+ regulatory T cells and CD8+ infiltration into the mucosa was not statistically significant. CXCR3 surface expression was not significantly different among different lymphocyte subsets. We conclude that engagement of HVEM during the acute phase of HSV infection influences the antiviral CD8+ recall response by an unexplained mechanism
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