Status, security and change: An ethnographic study of caste, class and religion in rural Rajasthan.

Based on 17 months ethnographic research carried out in a medium sized village in North West Rajasthan, this thesis explores the relationship between status, security and social change in a context of extreme economic uncertainty. Through changes in tenancy laws, the redistribution of land after the abolition of Zamindars in the 1950s, the withdrawal of high castes from the village, success through affirmative action policies, and caste mobilisation via Sanskritisation an extended family of the untouchable leatherworking caste Meghval in the village of Mudharamsar have risen to be the new village elites. Their unusual position as wealthy landowners and political agents has caused conflicts, alternative commensalities, and 're-traditionalised' practices amongst other villagers. This was further exacerbated by the temporary closure of mines in the area that provided the bulk of employment for other villagers causing many of the lower castes to search for alternative means of income and status-making. Some returned to their traditional caste occupations, others organised as a 'labour class' and Meghvals drew on kinship obligations in search of solidarity and security. I argue that social mobility and change amongst the rural poor involves both confluence and variance of what Betielle (1974) termed the 'ideas of caste' and the 'interests of class' underpinning agrarian relations. In doing so, I extend Beteille's analysis to situate my informants' ideas of caste, class and religion within their broader interests in constructing, claiming and using identity and status as mechanisms for coping with economic uncertainty, social change and inequality. I highlight the contradictions between normative ideals concerning caste, kinship and religion on the one hand, and changing class and power relations on the other. I am concerned to look at the spaces between these oppositions wherein alternative discourses and identities are generated, which at times bring unlikely actors together and at others reaffirm pre-existing relations

Impact of Long COVID on productivity and informal caregiving

BackgroundAround 2 million people in the UK suffer from Long COVID (LC). Of concern is the disease impact on productivity and informal care burden. This study aimed to quantify and value productivity losses and informal care receipt in a sample of LC patients in the UK.MethodsThe target population comprised LC patients referred to LC specialist clinics. The questionnaires included a health economics questionnaire (HEQ) measuring productivity impacts, informal care receipt and service utilisation, EQ-5D-5L, C19-YRS LC condition-specific measure, and sociodemographic and COVID-19 history variables. Outcomes were changes from the incident infection resulting in LC to the month preceding the survey in paid work status/h, work income, work performance and informal care receipt. The human capital approach valued productivity losses; the proxy goods method valued caregiving hours. The values were extrapolated nationally using published prevalence data. Multilevel regressions, nested by region, estimated associations between the outcomes and patient characteristics.Results366 patients responded to HEQ (mean LC duration 449.9 days). 51.7% reduced paid work hours relative to the pre-infection period. Mean monthly work income declined by 24.5%. The average aggregate value of productivity loss since incident infection was £10,929 (95% bootstrap confidence interval £8,844-£13,014) and £5.7 billion (£3.8-£7.6 billion) extrapolated nationally. The corresponding values for informal caregiving were £8,726 (£6,247-£11,204) and £4.8 billion (£2.6-£7.0 billion). Multivariate analyses found significant associations between each outcome and health utility and C19-YRS subscale scores.ConclusionLC significantly impacts productivity losses and provision of informal care, exacerbated by high national prevalence of LC

Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining

Molecular target identification is of central importance to drug discovery. Here, we developed a computational approach, named bioactivity profile similarity search (BASS), for associating targets to small molecules by using the known target annotations of related compounds from public databases. To evaluate BASS, a bioactivity profile database was constructed using 4296 compounds that were commonly tested in the US National Cancer Institute 60 human tumor cell line anticancer drug screen (NCI-60). Each compound was used as a query to search against the entire bioactivity profile database, and reference compounds with similar bioactivity profiles above a threshold of 0.75 were considered as neighbor compounds of the query. Potential targets were subsequently linked to the identified neighbor compounds by using the known targets o

Race, Racism and Anthropology: Decolonising Health Inequality in a Time of Covid-19

In the United Kingdom, the government’s failure to consistently record the race and ethnicity of those who have died from COVID-19 and the disproportionate mortality impact of the virus on Black, Asian and Minority Ethnic (BAME) communities speaks to a systemic failure to account for the interplay between the social construction of race and the lived experience of racism, itself presented biologically as ‘poor health’. This failure has run for far longer and far deeper than many would care to admit. In this article, I use my own positionality as a ‘Mixed-Race Black’ woman to argue that the unique place of medical anthropology to sit at the intersection of the social, political, biological, and ecological means it can provide alternative approaches to understanding the disproportionate impacts of the pandemic and lay some foundations for repair strategies that encompass the patterns, processes, and constructs of health inequality

‘You’re just a Guinea pig’: Exploring the barriers and impacts of living with long COVID‐19: A view from the undiagnosed

The COVID‐19 pandemic had a disproportionate impact on ethnically minoritised and other marginalised communities, yet little is known about the impacts of long COVID‐19 (LC) on this group. Living with LC takes its toll both physically, emotionally and financially and even more so when a diagnosis is hard to come by. By using qualitative interviews centring the view of undiagnosed and marginalised communities already classed as ‘underserved’ in the medical literature, we show the range of barriers and impacts faced by these groups in the UK, and the strategies of resilience they use. Whether trapped on a ‘diagnostic odyssey’ at the level of primary care, struggling to maintain employment and businesses, or managing family commitments, we argue many minoritised communities are caught in a liminal space of misrecognition, invalidation and ambiguity. We show how these impacts are generated by tensions and challenges in the process and categorisation of diagnosis, and how this effects the daily lives of many individuals already on the receiving end of health inequity. We also offer some examples and suggestions for best practices