9,319 research outputs found
3D MHD Modeling of the Gaseous Structure of the Galaxy: Synthetic Observations
We generated synthetic observations from the four-arm model presented in
Gomez & Cox (2004) for the Galactic ISM in the presence of a spiral
gravitational perturbation. We found that velocity crowding and diffusion have
a strong effect in the l-v diagram. The v-b diagram presents structures at the
expected spiral arm velocities, that can be explained by the off-the-plane
structure of the arms presented in previous papers of this series. Such
structures are observed in the Leiden/Dwingeloo HI survey. The rotation curve,
as measured from the inside of the modeled galaxy, shows similarities with the
observed one for the Milky Way Galaxy, although it has large deviations from
the smooth circular rotation corresponding to the background potential. The
magnetic field inferred from a synthetic synchrotron map shows a largely
circular structure, but with interesting deviations in the midplane due to
distortion of the field from circularity in the interarm regions.Comment: Accepted for publication in ApJ. Better quality figures in
http://www.astro.umd.edu/~gomez/publica/3d_galaxy-3.pd
Evolutionary Algorithms, Markov Decision Processes, Adaptive Critic Designs, and Clustering: Commonalities, Hybridization and Performance
We briefly review and compare the mathematical formulation of Markov decision processes (MDP) and evolutionary algorithms (EA). In so doing, we observe that the adaptive critic design (ACD) approach to MDP can be viewed as a special form of EA. This leads us to pose pertinent questions about possible expansions of the methodology of ACD. This expansive view of EA is not limited to ACD. We discuss how it is possible to consider the powerful chained Lin Kernighan (chained LK) algorithm for the traveling salesman problem (TSP) as a degenerate case of EA. Finally, we review some recent TSP results, using clustering to divide-and-conquer, that provide superior speed and scalability
The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA
Background: Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes a T3SS required for intracellular survival of the pathogen. Genes in SPI-2 include apparatus components, secreted effectors and chaperones that bind to secreted cargo to coordinate their release from the bacterial cell. Although the effector repertoire secreted by the SPI-2 T3SS is large, only three virulence-associated chaperones have been characterized. Results: Here we report that SscA is the chaperone for the SseC translocon component. We show that SscA and SseC interact in bacterial cells and that deletion of sscA results in a loss of SseC secretion, which compromises intracellular replication and leads to a loss of competitive fitness in mice. Conclusions: This work completes the characterization of the chaperone complement within SPI-2 and identifies SscA as the chaperone for the SseC translocon
Constraining the Collisional Nature of the Dark Matter Through Observations of Gravitational Wakes
We propose to use gravitational wakes as a direct observational probe of the
collisional nature of the dark matter. We calculate analytically the structure
of a wake generated by the motion of a galaxy in the core of an X-ray cluster
for dark matter in the highly-collisional and collisionless limits. We show
that the difference between these limits can be recovered from detailed X-ray
or weak lensing observations. We also discuss the sizes of sub-halos in these
limits. Preliminary X-ray data on the motion of NGC 1404 through the Fornax
group disfavors fluid-like dark matter but does not exclude scenarios in which
the dark matter is weakly collisional.Comment: 29 pages, 3 figures, submitted to Ap
Production of Milky Way structure by the Magellanic Clouds
Previous attempts at disturbing the galactic disk by the Magellanic Clouds
relied on direct tidal forcing. However, by allowing the halo to actively
respond rather than remain a rigid contributor to the rotation curve, the
Clouds may produce a wake in the halo which then distorts the disk. Recent work
reported here suggests that the Magellanic Clouds use this mechanism to produce
disk distortions sufficient to account for both the radial location, position
angle and sign of the HI warp and observed anomalies in stellar kinematics
towards the galactic anticenter and LSR motion.Comment: 8 pages, uuencoded compressed PostScript, no figures, html version
with figures and mpeg simulations available at
http://www-astro.phast.umass.edu/Preprints/martin/martin1/lmc_online.htm
Dissimilar response of plant and soil biota communities to long-term nutrient adition in grasslands
The long-term effect of fertilizers on plant diversity and productivity is well known, but long-term effects on soil biota communities have received relatively little attention. Here, we used an exceptional long-lasting (>40 years) grassland fertilization experiment to investigate the long-term effect of Ca, N, PK, and NPK addition on the productivity and diversity of both vegetation and soil biota. Whereas plant diversity increased by liming and decreased by N and NPK, the diversity of nematodes, collembolans, mites, and enchytraeids increased by N, PK, or NPK. Fertilization with NPK and PK increased plant biomass and biomass of enchytraeids and collembolans. Biomass of nematodes and earthworms increased by liming. Our results suggest that soil diversity might be driven by plant productivity rather than by plant diversity. This may imply that the selection of measures for restoring or conserving plant diversity may decrease soil biota diversity. This needs to be tested in future experiment
Ultraviolet Signposts of Resonant Dynamics in the Starburst-Ringed Sab Galaxy, M94 (NGC 4736)
M94 (NGC 4736) is investigated using images from the Ultraviolet Imaging
Telescope (FUV-band), Hubble Space Telescope (NUV-band), Kitt Peak 0.9-m
telescope (H-alpha, R, and I bands), and Palomar 5-m telescope (B-band), along
with spectra from the International Ultraviolet Explorer and Lick 1-m
telescopes. The wide-field UIT image shows FUV emission from (a) an elongated
nucleus, (b) a diffuse inner disk, where H-alpha is observed in absorption, (c)
a bright inner ring of H II regions at the perimeter of the inner disk (R = 48
arcsec. = 1.1 kpc), and (d) two 500-pc size knots of hot stars exterior to the
ring on diametrically opposite sides of the nucleus (R= 130 arcsec. = 2.9 kpc).
The HST/FOC image resolves the NUV emission from the nuclear region into a
bright core and a faint 20 arcsec. long ``mini-bar'' at a position angle of 30
deg. Optical and IUE spectroscopy of the nucleus and diffuse inner disk
indicates an approximately 10^7 or 10^8 yr-old stellar population from
low-level starbirth activity blended with some LINER activity. Analysis of the
H-alpha, FUV, NUV, B, R, and I-band emission along with other observed tracers
of stars and gas in M94 indicates that most of the star formation is being
orchestrated via ring-bar dynamics involving the nuclear mini-bar, inner ring,
oval disk, and outer ring. The inner starburst ring and bi-symmetric knots at
intermediate radius, in particular, argue for bar-mediated resonances as the
primary drivers of evolution in M94 at the present epoch. Similar processes may
be governing the evolution of the ``core-dominated'' galaxies that have been
observed at high redshift. The gravitationally-lensed ``Pretzel Galaxy''
(0024+1654) at a redshift of approximately 1.5 provides an important precedent
in this regard.Comment: revised figure 1 (corrected coordinate labels on declination axis);
19 pages of text + 19 figures (jpg files); accepted for publication in A
Attachment as a framework to facilitate empowerment for people with severe mental illness
Objectives: Recovery and empowerment have evolved into key objectives in the treatment and care of people with severe mental illness (SMI), and interest has grown in the role of social relationships in recovery. This study is the first to explore whether attachment styles are related to levels of empowerment, and secondly, whether attachment anxiety and attachment avoidance are associated with lower empowerment levels, independently of quality and frequency of social contact. Design: We used a cross-sectional design. Methods: In a sample of 157 participants with SMI in outpatient care, associations between attachment (Revised Adult Attachment Scale), self-reported social functioning, and empowerment (Netherlands Empowerment List) were assessed. Results: Attachment anxiety and attachment avoidance were both associated with lower levels of empowerment. A stepwise multiple regression analysis showed that the prediction of empowerment was significantly improved by adding attachment anxiety and attachment avoidance to quality and frequency of social contact. Attachment anxiety, attachment avoidance, and quality of social contact were significant predictors; frequency of social contact was not. Conclusions: Although our design does not allow causal conclusions, our results highlight the importance of interpersonal processes and behaviours as routes to improving empowerment for people with SMI. A promising approach might thus consist of securing attachment bonds with significant others so that the self and the other are perceived as reliable resources. Our findings also feature the importance of reciprocity and equality in social relationships. Taken together, our study emphasizes the value of social, contextualized interventions in recovery work for people with SMI. Practitioner points: Working towards attachment safety in interpersonal relations may be important in recovery-oriented treatment and care for people with severe mental illness (SMI). Helping people with SMI to recognize and change how they tend to relate themselves to others may promote engagement and effectiveness of recovery-oriented treatment and care. Reciprocity and equality in social relationships as vital complements to the more one-sided nature of ‘standing alongside’ and offering support may be important requisites for empowerment
Empirical maximum lifespan of earthworms is twice that of mice
We considered a Gompertzian model for the population dynamics of Eisenia andrei case-cohorts in artificial OECD soil under strictly controlled conditions. The earthworm culture was kept between 18 and 22°C at a constant pH of 5.0. In all, 77 lumbricids were carefully followed for almost 9 years, until the oldest died. The Eisenia median longevity is 4.25 years and the oldest specimen was 8.73 years. Eisenia cocoons were hand-sorted every 3 weeks, washed in distilled water, placed in Petri dishes, and counted. Regular removal did not reduce breeding. Each fertile cocoon contained on average two or three embryos. The failure rates (mortality and infertility percentages) are smooth power functions where the rate at time (n + 1) captured most of the phenomenology of the previous rate at time n, as expected by the considered law, but not at both the beginning and the end of this long-term laboratory study
Gene3D: comprehensive structural and functional annotation of genomes
Gene3D provides comprehensive structural and functional annotation of most available protein sequences, including the UniProt, RefSeq and Integr8 resources. The main structural annotation is generated through scanning these sequences against the CATH structural domain database profile-HMM library. CATH is a database of manually derived PDB-based structural domains, placed within a hierarchy reflecting topology, homology and conservation and is able to infer more ancient and divergent homology relationships than sequence-based approaches. This data is supplemented with Pfam-A, other non-domain structural predictions (i.e. coiled coils) and experimental data from UniProt. In order to enhance the investigations possible with this data, we have also incorporated a variety of protein annotation resources, including protein–protein interaction data, GO functional assignments, KEGG pathways, FUNCAT functional descriptions and links to microarray expression data. All of this data can be accessed through a newly re-designed website that has a focus on flexibility and clarity, with searches that can be restricted to a single genome or across the entire sequence database. Currently Gene3D contains over 3.5 million domain assignments for nearly 5 million proteins including 527 completed genomes. This is available at: http://gene3d.biochem.ucl.ac.uk
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