Catastrophic consequences of the enormous use of hydroxychloroquine during COVID era on liver and kidney of male albino rats: an in-vivo study

Background: Hydroxychloroquine (HCQ) is mainly used for the treatment of malaria but during COVID trial, it was used against coronavirus though no history of the drug is known against SARS COV 2 or any other respiratory ailment. Many case studies showed the adverse effects on liver and kidney in many patients after the exposure of HCQ. The main aim of this study is to know the effect of HCQ drug on the liver and kidney of male albino rat at a range of human equivalent dose that was given during COVID period. Methods: After institutional animal ethics committee (IAEC) approval, ten male albino rats were obtained and divided into two groups-control and treated. Treated groups receives HCQ through oral gavage for six days and then serum, tissue enzymes and total serum bilirubin were measured. Histopathological study was done from liver and kidney tissue. After that statistical analysis was done. Results: We found significant increase in enzymes glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and alkaline phosphatase (ALP) in the HCQ-treated rats than in control and this signifies that there might be damages that occurred in liver and kidney. Increased level of bilirubin in HCQ-treated rats indicate hyperbilirubinemia and may be a sign of jaundice or any other hepatic disorder. From histopathological identification we also found liver and kidney tissues got damaged due to exposure of HCQ. Conclusions: From this study, we can conclude that the exposure of this drug might have led to the impaired function of organs that could have potentiated their ill fate

Full waveform inversion in time and frequency domain of velocity modeling in seismic imaging: FWISIMAT a Matlab code

This paper investigates the capability of acoustic Full Waveform Inversion (FWI) in building Marmousi velocity model, in time and frequency domain. FWI is an iterative minimization of misfit between observed and calculated data which is generally solved in three segments: forward modeling, which numerically solves the wave equation with an initial model, gradient computation of the objective function, and updating the model parameters, with a valid optimization method. FWI codes developed in MATLAB herein FWISIMAT (Full Waveform Inversion in Seismic Imaging using MATLAB) are successfully implemented using the Marmousi velocity model as the true model. An initial model is obtained by smoothing the true model to initiate FWI procedure. Smoothing ensures an adequate starting model for FWI, as the FWI procedure is known to be sensitive on the starting model. The final model is compared with the true model to review the number of recovered velocities. FWI codes developed in MATLAB herein FWISIMAT (Full Waveform Inversion in Seismic Imaging using MATLAB) are successfully implemented usingMarmousi velocity model astrue model. An initial model is derived from smoothing the true model to initiate FWI procedure. Smoothing ensures an adequate starting model for FWI, as the FWI procedure is known to be sensitive onstarting model. The final model is compared with the true model to review theamount of recovered velocities

Syntheses and structural investigation of some alkali metal ion-mediated (LVO2-)-O-V (L2- = tridentate ONO ligands) species: DNA binding, photoinduced DNA cleavage and cytotoxic activities

Eight alkali metal ion-mediated dioxidovanadium(V), {(VO2L1-6)-O-V} A(H2O)n]proportional to, complexes for A = Li+, Na+, K+ and Cs+, containing tridentate aroylhydrazonate ligands coordinating via ONO donor atoms, are described. All the synthesised ligands and the metal complexes were successfully characterised by elemental analysis, IR, UV-Vis and NMR spectroscopy. X-ray crystallographic investigation of 3, 5-7 shows the presence of distorted NO4 coordination geometries for LVO2- in each case, and varying mu-oxido and/ or mu-aqua bridging with interesting variations correlated with the size of the alkali metal ions: with small Li+, no bridging-O is found but four ion aggregates are found with Na+, chains for K+ and finally, layers for Cs+. Two (5) or three-dimensional (3, 6 and 7) architectures are consolidated by hydrogen bonding. The dioxidovanadium(V) complexes were found to exhibit DNA binding activity due to their interaction with CT-DNA by the groove binding mode, with binding constants ranging from 10(3) to 10(4) M-1. Complexes 1-8 were also tested for DNA nuclease activity against pUC19 plasmid DNA which showed that 6 and 7 had the best DNA binding and photonuclease activity; these results support their good protein binding and cleavage activity with binding constants ranging from 104 to 105 M-1. Finally, the in vitro antiproliferative activity of all complexes was assayed against the HeLa cell line. Some of the complexes (2, 5, 6 and 7) show considerable activity compared to commonly used chemotherapeutic drugs. The variation in cytotoxicity of the complexes is influenced by the various functional groups attached to the aroylhydrazone derivative

Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic Activity

Three highly stable, hexacoordinated nonoxidovanadium(IV), V-IV(L)(2), complexes (1-3) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N3O3 donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex 3 being the most potent, which is comparable to insulin at the complex concentration of 4 mu M, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes 1-3 against the He La cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and 2 showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs

Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic Activity

Three highly stable, hexacoordinated nonoxidovanadium­(IV), V^IV(L)₂, complexes (<b>1</b>–<b>3</b>) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium­(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium­(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N₃O₃ donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex <b>3</b> being the most potent, which is comparable to insulin at the complex concentration of 4 μM, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes <b>1</b>–<b>3</b> against the HeLa cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and <b>2</b> showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs

Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic Activity

Three highly stable, hexacoordinated nonoxidovanadium­(IV), V^IV(L)₂, complexes (<b>1</b>–<b>3</b>) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium­(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium­(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N₃O₃ donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex <b>3</b> being the most potent, which is comparable to insulin at the complex concentration of 4 μM, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes <b>1</b>–<b>3</b> against the HeLa cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and <b>2</b> showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs