Investigation of the presence of pregnancy rhinitis in the third trimester with rhinomanometry

Aim: Pregnancy rhinitis (PR) is characterized with nasal symptoms during pregnancy without any signs of respiratory infection and it usually disappears within 2 weeks after delivery. We aimed to investigate the relationship between pregnancy rhinitis and findings derived from anterior rhinoscopy (AnR), anterior rhinomanometry (ARM) and subjective nasal obstruction score (SNOS). Methods: This prospective, controlled study was performed in otorhinolaryngology and obstetrics and gynecology departments of our tertiary care center. A total of 30 pregnant women in the third trimester and 30 non-pregnant women were involved. All participants underwent otorhinolaryngology examination, as well as clinical evaluation for AnR, ARM and SNOS. Results: Pregnancy rhinitis was detected in 66.7% of the pregnant women. The mean AnR was 3.60 ± 1.35 in pregnant women and 0.77 ± 0.73 in the control group. Total nasal inspiratory resistance (TNID) was 0.46±0.23 in pregnant women and 0.27±0.06 in the control group. The mean SNOS was 1.37±0.72 in pregnant women and 0.57±0.63 in the control group. AnR, ARM and SNOS findings were significantly higher in pregnant women (p<0.05). There is a low positive and significant correlation between AnR, ARM, and SNOS values in pregnant women (p<0.05). Conclusion: Our data yielded that nasal obstruction and pregnancy rhinitis were common in pregnant women.  Nasal symptoms and complaints must be carefully examined during pregnancy. Further prospective, controlled, randomized trials on larger series are warranted to elucidate the clinical and pathophysiological features of pregnancy rhinitis

The effect of nasal septum deviation on subclinical cardiac autonomic dysfunction

Background: Nasal septum deviation is one of the most frequently encountered nasal pathology in otorhinolaryngology clinics. Disease with a high comorbidity such as obstructive sleep apnea syndrome (OSAS), among whose etiology septum deviation takes place, can cause subclinical pathologies like atrial fibrillation. The main objective of this study was to determine the effect of nasal septum deviation on subclinical cardiac pathologies.Methods: The study included a total of 80 patients which were a group of 40 patients who admitted to the otorhinolaryngology department with a complaint of nasal obstruction and were diagnosed as having nasal septum deviation and a control group of 40 patients who admitted to the same department with complaints other than nasal obstruction and had no nasal septum deviation for the period of April 2015-August 2015. Initially, all patients were performed rhinomanometric measurement and then the patients were required to grade their symptoms of nasal obstruction using a 10-unit visual analog scale (VAS). Following that, patients were performed to transthoracic echocardiography by cardiology department and all the results were compared between two groups.Results: In the patient group while the VAS and transnasal pressure were found meaningful higher, the transnasal flow was found meaningful lower than the control group. In the patient group PA septum, PA tricuspide, PA lateral-tricuspide, PA septum-tricuspide values were found meaningful higher than the control group. In the patient group left atrium width (LA), LA volume maximum, LA volume minimum and LA volume p values, which show the size of left atrium, were found meaningful high in comparison to the control group.Conclusions: As a result of the data obtained from this study, the research demonstrates that nasal septum deviation can cause subclinical cardiac pathologies such as atrial fibrillation and these pathologies can be detected with noninvasive methods such as echocardiography

The effect of nasal septum deviation on subclinical cardiac autonomic dysfunction

Background: Nasal septum deviation is one of the most frequently encountered nasal pathology in otorhinolaryngology clinics. Disease with a high comorbidity such as obstructive sleep apnea syndrome (OSAS), among whose etiology septum deviation takes place, can cause subclinical pathologies like atrial fibrillation. The main objective of this study was to determine the effect of nasal septum deviation on subclinical cardiac pathologies.Methods: The study included a total of 80 patients which were a group of 40 patients who admitted to the otorhinolaryngology department with a complaint of nasal obstruction and were diagnosed as having nasal septum deviation and a control group of 40 patients who admitted to the same department with complaints other than nasal obstruction and had no nasal septum deviation for the period of April 2015-August 2015. Initially, all patients were performed rhinomanometric measurement and then the patients were required to grade their symptoms of nasal obstruction using a 10-unit visual analog scale (VAS). Following that, patients were performed to transthoracic echocardiography by cardiology department and all the results were compared between two groups.Results: In the patient group while the VAS and transnasal pressure were found meaningful higher, the transnasal flow was found meaningful lower than the control group. In the patient group PA septum, PA tricuspide, PA lateral-tricuspide, PA septum-tricuspide values were found meaningful higher than the control group. In the patient group left atrium width (LA), LA volume maximum, LA volume minimum and LA volume p values, which show the size of left atrium, were found meaningful high in comparison to the control group.Conclusions: As a result of the data obtained from this study, the research demonstrates that nasal septum deviation can cause subclinical cardiac pathologies such as atrial fibrillation and these pathologies can be detected with noninvasive methods such as echocardiography

The impact of topical and systemic enoxaparin sodium use on traumatic tympanic membrane perforation and myringosclerosis

The objective of this study is to investigate the effect of topical and systemic enoxaparin sodium on the healing pattern of experimentally induced tympanic membrane perforation and formation of myringosclerosis. A total of 24 Wistar-Albino strain rats were included in the study. Standard myringotomies were performed on each rat. In the first group, isotonic serum physiologic was dropped on external ear canal (control group). Topical enoxaparin was dropped on external ear canal and daily topical doses of enoxaparin were dropped on external ear canal of the rats for 14 days (topical treatment group). Third group received subcutaneous injections of enoxaparin for 14 days (systemic treatment group). Five micrometer thick sections of the bullae of the rats were stained with H&E. Inflammation, edema and sclerotic lesions and neovascularization observed in the lamina propria layer of the tympanic membrane, and total thickness of the tympanic membrane were evaluated. In intergroup comparisons, significant difference in the distribution pattern of severity of inflammation in all three groups was not observed (p = 0.784, p > 0.05). Total TM thickness differed among all three groups (p = 0.028, p 0.05). A significant difference was not observed among three groups as for the distribution of myringosclerotic plaques, severity of edema and neovascularization in the lamina propria (p = 0.539, p > 0.05), (p = 0.063, p > 0.05), (p = 0.152, p > 0.05). Topical and systemic enoxaparin treatment did not prevent formation of sclerotic plaques; however, it decreased TM thickness significantly in comparison with the control group

Comparative elucidation on the phenolic fingerprint, sugars and antioxidant activity of white, orange and purple-fleshed sweet potatoes (Ipomoea batatas L.) as affected by different cooking methods

In this study, three cooking methods (baking, boiling, sous vide (SV)) were applied to Turkish sweet potatoes with three flesh colors (white, orange, purple) to examine the effects of the product color and cooking methods on the total phenolics, antioxidant activity, sugars, phenolic acids, and anthocyanins. LC-MS-MS was employed in the characterization of these compounds. It was observed that the product color and cooking method significantly affected the concentrations of bioactive compounds like polyphenols. Both the highest total phenolic content (11.36 mg/g) and antioxidant activity (DPPH (50.3 μM TE/g) and ABTS (63.53 μM TE/g)) were determined in the purple sweet potato cooked with the SV method. 10 phenolic acids were quantified in all samples which were in the highest amounts in the orange colored samples followed by the purple samples. Baking resulted in the highest total phenolic acids in all samples. 13 anthocyanins were detected in the purple-colored samples, while the SV cooking best preserved the anthocyanins. In sum, purple sweet potatoes cooked by SV are recommended for higher phenolic contents, antioxidant capacity and anthocyanins

Sensorineural hearing loss in pediatric celiac patients

Objective: Celiac disease (CD) is an immune-mediated chronic inflammatory gluten-dependent intestinal disease affecting 0.5-1% of the general population worldwide. CD is underdiagnosed even with sophisticated health care; approximately 10% of people affected by CD are now diagnosed. The recognition of the atypical extra-intestinal manifestations, including neurological disorders increased the diagnosis of CD. At present, no data are available on the presence of sensorineural hearing loss in pediatric CD patients. The aim of this study was to determine the incidence and severity of sensorineural hearing loss (SNHL) in different frequencies in pediatric CD patients

Expression of histamine receptors (H-1, H-2, and H-3) in the rabbit endolymphatic sac: an immunohistochemical study

WOS: 000251743600004PubMed: 18061827Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies. The aim of this study was to investigate the expression of histamine receptors (H-1, H-2, H-3) in the rabbit ES. Methods: A total of 10 healthy male New Zealand white rabbits weighing 2 to 3 kg were used in the experiments. For immunohistochemical studies, immunostaining was performed according to the avidin-biotin-peroxidase complex technique. Results: Serial sections of the ES of rabbits revealed the presence of H-1, H-2, and H-3 receptor immunoreactivity. Immunoreactive cells for all H-1, H-2, and H-3 were found in the epithelial and subepithelial layers of the duct and the proximal ES. In conclusion, this study showed the immunohistochemical localization of H-1, H-2, and H-3 receptors in the ES of rabbits. These receptors may be important in the homeostasis of the inner ear. In addition, they may be target receptors in the medical treatment of inner car disorders such as endolymphatic hydrops. (C) 2008 Published by Elsevier Inc

Evaluation Of Outer Hair Cell Function And Medial Olivocochlear Efferent System In Patients With Type Ii Diabetes Mellitus

Aim: This study was designed to investigate the function of outer hair cells and medial olivocochlear efferents in type II diabetes mellitus (DM). Materials and methods: There were 50 patients with type II DM and 51 age-and sex-matched healthy controls included in the study. Both groups were compared in terms of transient evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs), and contralateral suppression of TEOAE. Results: Pure tone thresholds of the patients with type II DM were significantly higher than in the controls (P < 0.05). The TEOAE amplitudes at 1 kHz and at 1.5, 2, 3, 4, and 6 kHz signal-to-noise ratio amplitudes on DPOAE testing were significantly lower in the patients than controls (P < 0.05). There was no significant difference between the type II DM and control groups regarding contralateral suppression test results of TEOAEs. Conclusion: Type II DM seems to impact the auditory system at the cochlear level by affecting the functions of outer hair cells, and it results in elevation of the thresholds on audiometry and a decrease in the amplitudes of otoacoustic emissions.WoSScopu

Audiological Findings in Celiac Disease

Objective: Celiac disease ( CD) is a gluten-triggered immune enteropathy caused by a genetic predisposition. Recent papers suggest that CD is increasingly recognized by extraintestinal findings. The aim of this study was to investigate the effect of CD on hearing pathway including the olivocochlear efferent system in children. Methods: Forty-one pediatric CD patients and 31 controls were included in the study. Both groups were evaluated with audiometry, tympanometry, transiently evoked otoacoustic emission (TEOAE), distortion product otoacoustic emission (DPOAE), and contralateral suppression of the TEOAE. Results: The threshold at 250 Hz of the patients with CD was significantly higher (p < 0.05 in CD compared to control group, p < 0.0001). The signal to noise ratio (SNR) amplitudes in DPOAE testing and the SNR amplitudes with and without contralateral acoustic stimulus in TEOAE testing were significantly lower at 1,000 Hz in the CD compared to the control group. There was no significant difference between the CD and the control group regarding contralateral suppression amplitudes. Conclusion: CD seems to have an important impact on the auditory system, and results in an elevation of the thresholds at 250 Hz on audiometry and a decrease in the amplitudes of DPOAE and linear TEOAE at 1,000 Hz in children. Copyright (C) 2011 S. Karger AG, Base