Tribological characteristics comparison of formulated palm trimethylolpropane ester and polyalphaolefin for cam/tappet interface of direct acting valve train system

Purpose There is a continuous drive in automotive sector to shift from conventional lubricants to environmental friendly ones without adversely affecting critical tribological performance parameters. Because of their favorable tribological properties, chemically modified vegetable oils such as palm trimethylolpropane ester (TMP) are one of the potential candidates for the said role. To prove the suitability of TMP for applications involving boundary-lubrication regime such as cam/tappet interface of direct acting valve train system, a logical step forward is to investigate their compatibility with conventional lubricant additives. Design/methodology/approach In this study, extreme pressure and tribological characteristics of TMP, formulated with glycerol mono-oleate (GMO), molybdenum dithiocarbamate (MoDTC) and zinc dialkyldithiophosphate (ZDDP), has been investigated using four-ball wear tester and valve train test rig. For comparison, additive-free and formulated versions of polyalphaolefin (PAO) were used as reference. Moreover, various surface characterization techniques were deployed to investigate mechanisms responsible for a particular tribological behavior. Findings In additive-free form, TMP demonstrated better extreme pressure characteristics compared to PAO and lubricant additives which are actually optimized for conventional base-oils such as PAO, are also proved to be compatible with TMP to some extent, especially ZDDP. During cylinder head tests, additive-free TMP proved to be more effective compared to PAO in reducing friction of cam/tappet interface, but opposite behavior was seen when formulated lubricants were used. Therefore, there is a need to synthesize specialized friction modifiers, anti-wear and extreme pressure additives for TMP before using it as engine lubricant base-oil. Originality/value In this study, additive-free and formulated versions of bio-lubricant are tested for cam/tappet interface of direct acting valve train system of commercial passenger car diesel engine for the very test time. Another important aspect of this research was comparison of important tribological performance parameters (friction torque, wear, rotational speed of tappet) of TMP-based lubricants with conventional lubricant base oil, that is, PAO and its formulated version

Tribological characteristics comparison of formulated palm trimethylolpropane ester and polyalphaolefin for cam/tappet interface of direct acting valve train system

Purpose: There is a continuous drive in automotive sector to shift from conventional lubricants to environmental friendly ones without adversely affecting critical tribological performance parameters. Because of their favorable tribological properties, chemically modified vegetable oils such as palm trimethylolpropane ester (TMP) are one of the potential candidates for the said role. To prove the suitability of TMP for applications involving boundary-lubrication regime such as cam/tappet interface of direct acting valve train system, a logical step forward is to investigate their compatibility with conventional lubricant additives. Design/methodology/approach: In this study, extreme pressure and tribological characteristics of TMP, formulated with glycerol mono-oleate (GMO), molybdenum dithiocarbamate (MoDTC) and zinc dialkyldithiophosphate (ZDDP), has been investigated using four-ball wear tester and valve train test rig. For comparison, additive-free and formulated versions of polyalphaolefin (PAO) were used as reference. Moreover, various surface characterization techniques were deployed to investigate mechanisms responsible for a particular tribological behavior. Findings: In additive-free form, TMP demonstrated better extreme pressure characteristics compared to PAO and lubricant additives which are actually optimized for conventional base-oils such as PAO, are also proved to be compatible with TMP to some extent, especially ZDDP. During cylinder head tests, additive-free TMP proved to be more effective compared to PAO in reducing friction of cam/tappet interface, but opposite behavior was seen when formulated lubricants were used. Therefore, there is a need to synthesize specialized friction modifiers, anti-wear and extreme pressure additives for TMP before using it as engine lubricant base-oil. Originality/value: In this study, additive-free and formulated versions of bio-lubricant are tested for cam/tappet interface of direct acting valve train system of commercial passenger car diesel engine for the very test time. Another important aspect of this research was comparison of important tribological performance parameters (friction torque, wear, rotational speed of tappet) of TMP-based lubricants with conventional lubricant base oil, that is, PAO and its formulated version

The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance

Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF, rs1063856 (c.2365A>G) and rs1063857 (c.2385T>C), although to date the mechanistic basis for their association with VWF level is unknown. Using genotypic/phenotypic information from a European healthy control population, in vitro analyses of recombinant VWF expressing both SNVs, and in vivo murine models, this study determined the precise nature of their association with VWF level and investigated the mechanism(s) involved. Possession of either SNV corresponded with a significant increase in plasma VWF in healthy controls (P G on VWF levels was also confirmed in vivo. This increase in VWF protein corresponded to an increase in VWF messenger RNA (mRNA) resulting, in part, from prolonged mRNA half-life. In addition, coinheritance of both SNVs was associated with a lower VWF propeptide-to-VWF antigen ratio in healthy controls (P < .05) and a longer VWF half-life in VWF knockout mice (P < .0001). Both SNVs therefore directly increase VWF plasma levels through a combined influence on VWF biosynthesis and clearance, and may have an impact on disease phenotype in both hemostatic and thrombotic disorders

Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

BACKGROUND: During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study\u27s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines. METHODS: We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March-31 May 2020. The prior 1-year control period (1 March-31 May 2019) was obtained to account for seasonal variation. FINDINGS: There was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI -24.3% to -20.7%, p\u3c0.0001). Embolisation of ruptured aneurysms declined with 1170-1035 procedures, respectively, representing an 11.5% (95%CI -13.5% to -9.8%, p=0.002) relative drop. Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations, a 24.9% relative decline (95% CI -28.0% to -22.1%, p\u3c0.0001). A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1% (95% CI 32.3% to 50.6%, p=0.008) despite a decrease in SAH admissions in this tertile. INTERPRETATION: There was a relative decrease in the volume of SAH hospitalisations, aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic. These findings in SAH are consistent with a decrease in other emergencies, such as stroke and myocardial infarction

Molecular characterization of exonic rearrangements and frame shifts in the dystrophin gene in Duchenne muscular dystrophy patients in a Saudi community

Abstract Background In individuals with Duchenne muscular dystrophy (DMD), exon skipping treatment to restore a wild-type phenotype or correct the frame shift of the mRNA transcript of the dystrophin (DMD) gene are mutation-specific. To explore the molecular characterization of DMD rearrangements and predict the reading frame, we simultaneously screened all 79 DMD gene exons of 45 unrelated male DMD patients using a multiplex ligation-dependent probe amplification (MLPA) assay for deletion/duplication patterns. Multiplex PCR was used to confirm single deletions detected by the MLPA. Results There was an obvious diagnostic delay, with an extremely statistically significant difference between the age at initial symptoms and the age of clinical evaluation of DMD cases (t value, 10.3; 95% confidence interval 5.95–8.80, P < 0.0001); the mean difference between the two groups was 7.4 years. Overall, we identified 147 intragenic rearrangements: 46.3% deletions and 53.7% duplications. Most of the deletions (92.5%) were between exons 44 and 56, with exon 50 being the most frequently involved (19.1%). Eight new rearrangements, including a mixed deletion/duplication and double duplications, were linked to seven cases with DMD. Of all the cases, 17.8% had duplications with no hot spots. In addition, confirmation of the reading frame hypothesis helped account for new DMD rearrangements in this study. We found that 81% of our Saudi patients would potentially benefit from exon skipping, of which 42.9% had a mutation amenable to skipping of exon 51. Conclusions Our study could generate considerable data on mutational rearrangements that may promote future experimental therapies in Saudi Arabia