Imaging SAR phenomenology of concealed vibrating targets

This paper describes the novel imaging of SAR phenomena produced from vibrating targets with multipath effects. It has been established, through numerical SAR experiments, that different physical mechanisms interact to produce new artefacts. The computations demonstrated that the edges of a dielectric medium can act as a source for multipath effects to emanate from, leading to the hypothesis that SAR artefacts can arise from through-wall SAR imagery. This deduction and mechanism of origin were validated through several experimental measurements, undertaken at Cranfield University’s Antennas and Ground-based SAR laboratory, yielding results that closely match those predicted

Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice

Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. More than 30% of patients develop lung metastasis, which is the leading cause of mortality. Recently, the extracellular matrix protein Cyr61 has been recognized as a malignancy promoting protein in OS mouse model with prognostic potential in human OS. In this study, we aimed at the identification of novel Cyr61-interacting proteins. Here we report that Cyr61 associates with Caprin-1, and confocal microscopy showed that stable ectopic expression of Caprin-1 leads to the formation of stress granules containing Caprin-1 and Cyr61, confers resistance to cisplatin-induced apoptosis, and resulted in constitutive phosphorylation of Akt and ERK1/2. Importantly, ectopic expression of Caprin-1 dramatically enhanced primary tumor growth, remarkably increased lung metastatic load in a SCID intratibial OS mouse model, and decreased significantly (p<0.0018) the survival of the mice. Although Caprin-1 expression, evaluated with a tissue microarray including samples from 59 OS patients, failed to be an independent predictor for the patients' outcome in this limited cohort of patients, increased Caprin-1 expression indicated a tendency to shortened overall survival, and more strikingly, Cyr61/Caprin-1 co-expression was associated with worse survival than that observed for patients with tumors expressing either Cyr61 or Caprin-1 alone or none of these proteins. The findings imply that Caprin-1 may have a metastasis promoting role in OS and show that through resistance to apoptosis and via the activation of Akt and ERK1/2 pathways, Caprin-1 is significantly involved in the development of OS metastasis

Detection of aerial features by ground diffraction patterning in SAR imagery

We report on an investigation into the secondary detection of objects in SAR imagery by the presence of diffraction patterning. Laboratory SAR imaging measurements were carried on metal pipes suspended above a gravel surface. Clear fringe patterns were seen across the imaged gravel in both backscatter and interferometric phase. Modelling was carried out using an incremental diffraction algorithm. The positioning and modulation characteristics of the fringes could be understood by the relative positioning of the targets above the gravel and the imaging geometries. Even if the pipes or wires are not visible in the imagery from the direct return, their presence might be inferred from the persistent presence of ground fringes