A minimum hypothesis explanation for an IMF with a lognormal body and power law tail

We present a minimum hypothesis model for an IMF that resembles a lognormal distribution at low masses but has a distinct power-law tail. Even if the central limit theorem ensures a lognormal distribution of condensation masses at birth, a power-law tail in the distribution arises due to accretion from the ambient cloud, coupled with a non-uniform (exponential) distribution of accretion times.Comment: 2 pages, 1 figure, to appear in IMF@50, eds. E. Corbelli, F. Palla, and H. Zinnecker, Kluwer, Astrophysics and Space Science Librar

Angiotensin blockade for diabetes: Monitor microalbuminuria?

No studies address whether continued screening for microalbuminuria once a patient is taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin-2 receptor blocker (ARB) improves outcomes. Indirect evidence and expert opinion suggest that it may be beneficial to continue microalbuminuria surveillance to assess response to therapy and monitor disease progression (strength of recommendation: C, based on expert opinion)

Which tests are the most useful for diagnosing PID?

No single test has adequate sensitivity and specificity to reliably identify pelvic inflammatory disease (PID) and thus help to spare women serious sequelae, including infertility (strength of recommendation [SOR]: B, based on systematic reviews of cohort studies and individual cohort studies)

Unproceedings of the Fourth .Astronomy Conference (.Astronomy 4), Heidelberg, Germany, July 9-11 2012

The goal of the .Astronomy conference series is to bring together astronomers, educators, developers and others interested in using the Internet as a medium for astronomy. Attendance at the event is limited to approximately 50 participants, and days are split into mornings of scheduled talks, followed by 'unconference' afternoons, where sessions are defined by participants during the course of the event. Participants in unconference sessions are discouraged from formal presentations, with discussion, workshop-style formats or informal practical tutorials encouraged. The conference also designates one day as a 'hack day', in which attendees collaborate in groups on day-long projects for presentation the following morning. These hacks are often a way of concentrating effort, learning new skills, and exploring ideas in a practical fashion. The emphasis on informal, focused interaction makes recording proceedings more difficult than for a normal meeting. While the first .Astronomy conference is preserved formally in a book, more recent iterations are not documented. We therefore, in the spirit of .Astronomy, report 'unproceedings' from .Astronomy 4, which was held in Heidelberg in July 2012.Comment: 11 pages, 1 figure, .Astronomy 4, #dotastr

A Significant Population of Candidate New Members of the ρ Ophiuchi Cluster

We present a general method for identifying the pre-main-sequence population of any star-forming region, unbiased with respect to the presence or absence of disks, in contrast to samples selected primarily via their mid-infrared emission from Spitzer surveys. We have applied this technique to a new, deep, wide-field, near-infrared imaging survey of the ρ Ophiuchi cloud core to search for candidate low-mass members. In conjunction with published Spitzer IRAC photometry and least-squares fits of model spectra (COND, DUSTY, NextGen, and blackbody) to the observed spectral energy distributions, we have identified 948 candidate cloud members within our 90% completeness limits of J = 20.0, H = 20.0, and Ks = 18.50. This population represents a factor of ~3 increase in the number of known young stellar objects in the ρ Ophiuchi cloud. A large fraction of the candidate cluster members (81% ± 3%) exhibit infrared excess emission consistent with the presence of disks, thus strengthening the possibility of their being bona fide cloud members. Spectroscopic follow-up will confirm the nature of individual objects, better constrain their parameters, and allow an initial mass function to be derived

The Core of the Participatory Budgeting Problem

In participatory budgeting, communities collectively decide on the allocation of public tax dollars for local public projects. In this work, we consider the question of fairly aggregating the preferences of community members to determine an allocation of funds to projects. This problem is different from standard fair resource allocation because of public goods: The allocated goods benefit all users simultaneously. Fairness is crucial in participatory decision making, since generating equitable outcomes is an important goal of these processes. We argue that the classic game theoretic notion of core captures fairness in the setting. To compute the core, we first develop a novel characterization of a public goods market equilibrium called the Lindahl equilibrium, which is always a core solution. We then provide the first (to our knowledge) polynomial time algorithm for computing such an equilibrium for a broad set of utility functions; our algorithm also generalizes (in a non-trivial way) the well-known concept of proportional fairness. We use our theoretical insights to perform experiments on real participatory budgeting voting data. We empirically show that the core can be efficiently computed for utility functions that naturally model our practical setting, and examine the relation of the core with the familiar welfare objective. Finally, we address concerns of incentives and mechanism design by developing a randomized approximately dominant-strategy truthful mechanism building on the exponential mechanism from differential privacy

The Perils of Clumpfind: The Mass Spectrum of Sub-structures in Molecular Clouds

We study the mass spectrum of sub-structures in the Perseus Molecular Cloud Complex traced by 13CO (1-0), finding that $dN/dM\propto M^{-2.4}$ for the standard Clumpfind parameters. This result does not agree with the classical $dN/dM\propto M^{-1.6}$. To understand this discrepancy we study the robustness of the mass spectrum derived using the Clumpfind algorithm. Both 2D and 3D Clumpfind versions are tested, using 850 $\mu$m dust emission and 13CO spectral-line observations of Perseus, respectively. The effect of varying threshold is not important, but varying stepsize produces a different effect for 2D and 3D cases. In the 2D case, where emission is relatively isolated (associated with only the densest peaks in the cloud), the mass spectrum variability is negligible compared to the mass function fit uncertainties. In the 3D case, however, where the 13CO emission traces the bulk of the molecular cloud, the number of clumps and the derived mass spectrum are highly correlated with the stepsize used. The distinction between "2D" and "3D" here is more importantly also a distinction between "sparse" and "crowded" emission. In any "crowded" case, Clumpfind should not be used blindly to derive mass functions. Clumpfind's output in the "crowded" case can still offer a statistical description of emission useful in inter-comparisons, but the clump-list should not be treated as a robust region decomposition suitable to generate a physically-meaningful mass function. We conclude that the 13CO mass spectrum depends on the observations resolution, due to the hierarchical structure of MC.Comment: 5 pages, 3 figures. Accepted for publication in ApJ Letter

Multi-Conjugate Adaptive Optics images of the Trapezium Cluster

Multi-Conjugate Adaptive Optics (MCAO) combines the advantages of standard adaptive optics, which provides high contrast and high spatial resolution, and of wide field ~1' imaging. Up to recently, MCAO for astronomy was limited to laboratory experiments. In this paper, we present the first scientific results obtained with the first MCAO instrument put on the sky. We present a new study of the Trapezium cluster using deep MCAO images with a field of view of 1'x1' obtained at the VLT. We have used deep J, H and Ks images recently obtained with the prototype MCAO facility MAD at the VLT in order to search for new members and new multiple systems in the Trapezium cluster. On bright targets (Ks~9mag), these images allow us to reach DeltaKs~6mag as close as 0.4" We report the detection of 128 sources, including 10 new faint objects in the magnitude range between 16.1<Ks<17.9mag. In addition to all previously known multiple systems with separations greater than 0.1", we confirm the multiplicity of TCC-055. We also report the detection in J, H and Ks of a very red extended embedded protostellar object, HC419, previously detected in the thermal infrared only. The analysis of the first MCAO images obtained on the sky demonstrates not only the technical feasibility of MCAO but also its great potential and versatility in terms of scientific outputs.Comment: High resolution version available on http://arrakeen.free.fr/pub/madorion.pdf Accepted 25 Sep. 2007 for publication in A&A, 14 pages, 11 figure

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential.

We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets to identify functionally important and therapeutically relevant pathways downstream of oncogenic miRNA in MLL-r AML. We found Cdkn1b (p27Kip1) is a direct miR-196b target whose repression enhanced an embryonic stem cell–like signature associated with decreased leukemia latency and increased numbers of leukemia stem cells in vivo. Conversely, elevation of p27Kip1 significantly reduced MLL-r leukemia self-renewal, promoted monocytic differentiation of leukemic blasts, and induced cell death. Antagonism of miR-196b activity or pharmacologic inhibition of the Cks1-Skp2–containing SCF E3-ubiquitin ligase complex increased p27Kip1 and inhibited human AML growth. This work illustrates that understanding oncogenic miRNA target pathways can identify actionable targets in leukemia