(P2-37) The Triage and Medical Management of Alcoholized/Intoxicated Patients at the Zurich "Street Parade”, One of the Biggest "Techno Dance Parades” of Europe

Background Every year, the City of Zurich hosts the "Street Parade”. This is one of the biggest European "techno parade” dance parties attracting way over a half a million mostly young people who party on a 2 km route along the lakeside of the City. Many of these guests drink alcohol and some eventually consume other drugs (e.g., GHB, Ecstasy, LSD). Combinations of these drugs may affect conscience eventually leading to a critical medical condition. Until recently the emergency-posts at the scene, as well as the emergency rooms of the local hospitals have been "flooded” with such patients, leading to obvious logistical problems. Discussion of Intervention Over the last years the Ambulance Service of the City of Zurich utilized an unused shelter close to the event scene, where these "intoxicated” mostly young patients were medically supervised and taken care of. The shelter has room for 108 patients. Every patient is first triaged; if a patient suffers from something else than just "intoxication” (e.g., cuts from broken glass) he is sent directly to the hospital for adequate treatment. The patients are then numbered, if needed showered, and receive a bed where they are regularly assessed for pulse, oxygen saturation, blood pressure and GCS by professional personnel. In parallel, if their clothes are dirty, they are washed and dried so the patient will have something clean to dress at the moment of dismissal. The average time of the patients in this shelter is 3 hours 7 minute and the charge is 600 CHF (approx 620 USD). This system has been so helpful for the hospitals, they now supply medical personnel for no cost. Conclusion This system of triage and separate medical supervision of "simply” intoxicated patients has been successful in the management of a large number these kind of patient

Imputation of missing count data of recreational boat retrievals from remote camera surveys in the Perth Metropolitan region, Western Australia

In Western Australia (WA), remote cameras have been used to monitor boating activity at boat ramps since 2006 to assist in ongoing recreational fishing surveys. These monitoring schemes are useful tools to validate boating activity (defined here as the number of retrievals) and to corroborate estimates of recreational fishing effort obtained from other surveys. This is because remote cameras (also referred to as digital cameras) can provide complete coverage (i.e. 24 hours, 365 days) of boating activities

Nomadic pastoralism in southern Iran

The nomadic pastoralist system in Baft district in Kerman province is well known in Iran for producing cashmere from Raeini goats. However, there is little information on the production system. Interviews were carried out with 30 Siahjel nomad families of Raen origin in proximity of about 20 km to Baft city in 2010 to characterise the production system in terms of family labour force, work sharing, livestock numbers, management and marketing practices, and diseases. The nomads move their livestock over large distances within the rangelands of the region from May to November, and the majority migrate south during autumn and winter. Of the nomad families, 87% live with and manage their animals together with one or more other related families. All household heads are males. All family members are involved in raising livestock; males and hired labourers dominate the physically harder jobs like shepherding and breeding, while women are involved in milking and caring. Of the animals, 80% are owned by adult or young unmarried males, none by daughters. Average proportion of goats and sheep per family flock are 89% and 8%, respectively, which indicates that Siahjel nomads mainly rely on goats. Adult breeding females constituted the largest group within the goat herds. The rationale for keeping a high number of male goats may be related to their greater production of cashmere. Diseases accounted for 57% of adult and 88% of young animal deaths. The most prevalent diseases were enterotoxaemia, foot-and-mouth disease, pneumonia, agalactia and diarrhoea. Animal sales, meat, cashmere and milk production are the major reasons for keeping goats. Rangeland is considered as the main source of feeding (85% of total annual feed intake); the remaining 15% is provided by stubble grazing. However, the herds do not produce enough meat, milk and cashmere to sustain the life of the nomad families, and thus, they often have to sell part of their stock which will further decrease their income.Fil: Ansari-Renani, Hamid R. Animal Science Research Institute; IránFil: Rischkowsky, Barbara. International Center for Agricultural Research in the Dry Areas; EtiopíaFil: Mueller, Joaquin Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Seyed Momend, S.M. Agriculture and Natural Resources Research Center; IránFil: Moradi, Sepehr. Animal Science Research Institute; Irán. University of Mashad. Agriculture College. Animal Science Department; Irá

Observations on the efficiency of using different cashmere combs

The effect of using small or large cashmere combs on cashmere harvest, cashmere quality and combing time was studied on Raeini cashmere goats in nomadic goat breeding systems of the Iranian province of Kerman. Two groups of 20 goats of different ages were combed with either a large or a small comb, three times with intervals of 2 weeks in early spring when natural fiber shedding has started. Combed cashmere weight, duration of combing, fiber diameter, and down yield were measured. A sample of combed cashmere was analyzed using a Laserscan instrument. A general linear model including type of comb, stage of combing and age of goat was fitted to analyze the data. Small combs collect more cashmere (31.0 vs. 21.7 g, P 0.05) but combing time is higher (3.75 vs. 2.79 min, P < 0.01). In the first two combing sessions much more cashmere was obtained than in the last (28.1, 32.0 and 19.0 g, respectively, P < 0.01), but the weight of total combed cashmere was much less than typical shorn fleece weights. Combing can be justified only if a considerable price premium can be obtained from selling combed cashmere instead of selling shorn cashmere, or if the combed cashmere is used to add value on-farm. If this is the case, small combs with short rods are preferable since more cashmere can be collected without affecting its qualityFil: Ansari-Renani, Hamid R. Animal Science Research Institute; IránFil: Mueller, Joaquin Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Rischkowsky, Barbara. International Center for Agricultural Research in the Dry Areas; EtiopíaFil: Seyed Momend, S.M. Agriculture and Natural Resources Research Center; IránFil: Ehsani, M. Agriculture and Natural Resources Research Center; IránFil: Moradi, Sepehr. University of Zanjan. Agriculture College. Animal Science Department; Irá

Lösliche Guanylatzyklase(sGC)-Stimulation mit Vericiguat: Von der pharmakologischen Idee bis zur Therapie der chronischen Herzinsuffizienz [Soluble guanylate cyclase (sGC) stimulation with vericiguat : from the pharmacological idea to the treatment of chronic heart failure]

BACKGROUND: According to the new European Society of Cardiology (ESC) guidelines on the diagnostics and treatment of acute and chronic heart failure, vericiguat (Verquvo®) can be included in the treatment of adult patients with symptomatic chronic heart failure and reduced ejection fraction who, despite standard treatment after a recently occurring decompensation event, were stabilized with the necessary intravenous (i.v.) therapy. OBJECTIVE: This review article summarizes the development of vericiguat, a soluble guanylate cyclase stimulator (sGC stimulator), which is a good example for the stringent implementation of a novel pharmacological therapy approach into treatment of heart failure. It provides valuable approaches for the practical use via the characterization of this patient collective that was investigated for the first time. RESULTS: The two relevant trials in the clinical development program for vericiguat, SOCRATES-Reduced and VICTORIA, have clearly demonstrated the efficacy and safety of vericiguat. The primary efficacy endpoint in the VICTORIA study “cardiovascular death or hospitalization due to heart failure” was significantly reduced in the vericiguat arm compared to placebo. Relevant subgroup analyses as well as safety data confirm this result and support the safe use in this high-risk population. CONCLUSION: The presented data allow the conclusion that vericiguat can be efficaciously and safely added to an existing treatment with a recommended standard medication for heart failure. It can be expected that in the routine practice the target dose of 10 mg can be reliably reached and maintained. Vericiguat should be regarded as a novel, easy and safe treatment option in a vulnerable patient population, for which there was previously hardly any medicinal treatment option

Cashmere quality of Raeini goats kept by nomads in Iran

The income of the nomads in Kerman Province depends mainly on Raeini goats that produce meat, milk and cashmere. This paper assesses the cashmere quality and its variation in Raeini herds to determine the scope for improvement. In April 2010 fleece weights (FW) and midside fleece samples were taken from a total of 686 male and female cashmere goats of 1, 2 and 3 years of age belonging to 29 herds. The herds were randomly chosen in the summer grazing area of nomads within 20 km of the city of Baft, province of Kerman, South of Iran, the main cashmere producing area in Iran. Cashmere yield (CY) was determined from the weight of dehaired cashmere to weight of shorn fiber. Cashmere fibers were analyzed using an OFDA instrument. A general mixed linear model including sex, age and sex by age interaction as fixed effects and herd as random effect was used to analyze the data and measure the relationships between different cashmere characteristics and fleece attributes. The overall means ± standard deviations were for fleece weights (FW) 507 ± 183 g, cashmere yield (CY) 56.5 ± 12.2%, mean fiber diameter (MFD) 19.7 ± 1.5 μm, fiber diameter standard deviation (FDSD) 4.5 ± 0.6 μm, fiber curvature (FC) 62.9 ± 8.5°/mm and staple length (SL) 54.2 ± 7.0 mm, respectively. Herd effect was significant for all traits except for SL and sex by age effect was only significant for MFD. One year old males and females had finer cashmere than older goats. FW and FDSD were higher in males and CY and FC was higher in young animals. Pearson correlation between MFD and FC, FDSD and MFD, MFD and FW was −0.647, 0.399 and 0.211 respectively. Raeini cashmere is white, has an excellent SL and FC but is relatively coarse. Given the differences between and within herds there seems to be substantial scope to improve the commercial value of Raeini cashmere.Fil: Ansari-Renani, Hamid R. Animal Science Research Institute; IránFil: Mueller, Joaquin Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Rischkowsky, Barbara. International Center for Agricultural Research in the Dry Areas; SiriaFil: Seyed Momend, S.M. Agriculture and Natural Resources Research Center; IránFil: Alipour, O. Livestock Office of Agriculture Department of Baft; IránFil: Ehsani, M. Agriculture and Natural Resources Research Center; IránFil: Moradi, Sepehr. University of Zanjan. Agriculture College. Animal Science Department; Irán. Animal Science Research Institute; Irán

Strange form factors of the proton: a new analysis of the neutrino (antineutrino) data of the BNL-734 experiment

We consider ratios of elastic neutrino(antineutrino)-proton cross sections measured by the Brookhaven BNL-734 experiment and use them to obtain the neutral current (NC) over charged current (CC) neutrino-antineutrino asymmetry. We discuss the sensitivity of these ratios and of the asymmetry to the electric, magnetic and axial strange form factors of the nucleon and to the axial cutoff mass M_A. We show that the effects of the nuclear structure and interactions on the asymmetry and, in general, on ratios of cross sections are negligible. We find some restrictions on the possible values of the parameters characterizing the strange form factors. We show that a precise measurement of the neutrino-antineutrino asymmetry would allow the extraction of the axial and vector magnetic strange form factors in a model independent way. The neutrino-antineutrino asymmetry turns out to be almost independent on the electric strange form factor and on the axial cutoff mass.Comment: 12 page

Adverse events of endoscopic full-thickness resection:results from the German and Dutch nationwide colorectal FTRD registry

Background and Aims: Endoscopic full-thickness resection (eFTR) is emerging as a minimally invasive alternative to surgery for complex colorectal lesions. Previous studies have demonstrated favorable safety results; however, large studies representing a generalizable estimation of adverse events (AEs) are lacking. Our aim was to provide further insight in AEs after eFTR.Methods: Data from all registered eFTR procedures in the German and Dutch colorectal full-thickness resection device registries between July 2015 and March 2021 were collected. Safety outcomes included immediate and late AEs.Results: Of 1892 procedures, the overall AE rate was 11.3% (213/1892). No AE-related mortality occurred. Perforations occurred in 2.5% (47/1892) of all AEs, 57.4% (27/47) of immediate AEs, and 42.6% (20/47) of delayed AEs. Successful endoscopic closure was achieved in 29.8% of cases (13 immediate and 1 delayed), and antibiotic treatment was sufficient in 4.3% (2 delayed). The appendicitis rate for appendiceal lesions was 9.9% (13/131), and 46.2% (6/13) could be treated conservatively. The severe AE rate requiring surgery was 2.2% (42/1892), including delayed perforations in .9% (17/1892) and immediate perforations in .7% (13/1892). Delayed perforations occurred between days 1 and 10 (median, 2) after eFTR, and 58.8% (10/17) were located on the left side. Other severe AEs were appendicitis (.4%, 7/1892), luminal stenosis (.1%, 2/1892), delayed bleeding (.1%, 1/1892), pain after eFTR close to the dentate line (.1%, 1/1892), and grasper entrapment in the clip (.1%, 1/1892).Conclusions: Colorectal eFTR is a safe procedure with a low risk for severe AEs in everyday practice and without AE-related mortality. These results further support the position of eFTR as an established minimally invasive technique for complex colorectal lesions.</p

Perceptions and experiences with eating disorder treatment in the first year of COVID-19: A longitudinal qualitative analysis

Objective: The COVID-19 pandemic created significant challenges in accessing and receiving treatment for individuals with eating disorders (EDs). The purpose of this study is to explore perceptions of and experiences with ED treatment during the first year of the pandemic among individuals with past and self-reported EDs in the United States. Methods: Online surveys were administered to adults (N = 510) with a past or current self-reported ED at 13 timepoints between April 2020 and May 2021. Using longitudinal qualitative analysis, 5651 free-text responses were examined to capture experiences with ED treatment and generate inferences of change over time. Results: We categorized results into four sequential, temporal quarters and identified patterns that explained participants' perceptions of facilitators, barriers, and experiences with ED treatment over time: Quarter 1. Treatment Disruption and Reorienting Recovery; Quarter 2. Accumulating COVID-19 Stress and Virtual Treatment Woes; Quarter 3. A Continuation of Inadequate Care; and Quarter 4. Ongoing Adaptation and Adjustment to Uncertainty. Participant experiences were marked by numerous barriers to accessing care, challenges adjusting to virtual treatment, unmet treatment needs, and beginning acceptance of telehealth. Discussion: Our findings present a timeline to help evaluate challenges related to navigating the switch to virtual care which created significant disruption to ED recovery. Participants spent much of the first year trying to adjust to unemployment, loss of insurance, and lack of access to in-person treatment. Future research should identify additional strategies to improve the receipt and experience of care for EDs. Public Significance: Our findings suggest that individuals with eating disorders were significantly challenged by accumulating COVID-19 stress, worsening symptomatology, and limited access to effective treatment during the first year of the pandemic. This knowledge can guide clinicians, treatment centers, and policy makers in addressing the behavioral health needs of individuals impacted by disordered eating amidst emergent public health crises

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography–mass spectrometry. These PA were galloylated (≈40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384 Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575 mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode