From Print to Projection: An Analysis of Shakespearian Film Adaptation

A close relationship between literature and film is nothing new. For over 100 years, turning mental pictures into visual images has captivated filmmakers and viewers alike, allowing for further expression, interpretation, and sometimes understanding of the original text. Even the theatrical works of William Shakespeare have been adapted onto film, relocating the action from stage to screen and bringing his art to larger audiences than ever before. With the technology of film, the conventions of Elizabethan theatre are challenged as filmmakers choose to modify or relocate the action of the plot. But is this acceptable

Proposed Lewisville Canoe and Kayak Launch, Denton County, Texas

The City of Lewisville is proposing the construction of two canoe and kayak launch areas (North and South) along the Elm Fork Trinity River in Lewisville, Denton County, Texas. The proposed project consists of constructing water craft launch areas, vehicle parking areas, restroom facilities, and access roadways at each launch location. The North launch is located on property owned by U.S. Army Corps of Engineers (USACE) and managed by City of Lewisville. The 4.6-acre North launch is located approximately 300 feet (91.4 meters) downstream of the water discharge at Lewisville Lake Dam. The 4.1-acre South launch is on City of Lewisville property, about 6 river miles (9.7 kilometers) downstream of the North launch. Both proposed launch areas would be constructed on the west banks of the Elm Fork Trinity River. Jacobs conducted an intensive archeological survey to determine if any cultural resources sites are located within the project area and, if so, evaluate their eligibility for the National Register of Historic Places and/or designation as a State Antiquities Landmark. The investigations at the South launch were conducted under the Texas Antiquities Code (Permit No. 8173); work at the North launch was coordinated with USACE. The Principal Investigator for the project was Michael Mudd. The field survey was conducted 3-5 October 2017 and a total of 80 person-hours were invested for the project. The intensive archeological survey of the North and South launch areas resulted in the documentation of no prehistoric- or historic-age sites. Based on the findings, it is Jacobs’ opinion that no further archeological work is warranted for the project. However, in the unlikely event that any human remains or grave goods are inadvertently discovered at any point during construction, use, or ongoing maintenance of the property, even in previously surveyed areas, all work should cease immediately and the Texas Historical Commission should be notified of the discovery

An Intensive Archeological Survey of the Owl Hills-Tunstill 138-KV Transmission Line Route

Oncor Electric Delivery Company, LLC (Oncor) is planning to construct the Owl Hills—Tunstill 138-kV Transmission Line Route in Culberson, Reeves and Loving Counties, Texas. Oncor contracted with Halff Associates, Inc. to conduct an intensive pedestrian survey of 18.5 miles of new 138-kV transmission line on private property. The survey was conducted January 20-24, 2020 and a total of 102 shovel tests were excavated in areas where buried archeological deposits where expected, and two 15-meter (32.8-foot) transects underwent pedestrian survey within the 70-foot (21.3-meter) wide survey corridor, which measures approximately 157 acres. Three archeological sites (41RV208, 41RV209 and 41RV213) were identified and recorded during the archeological survey. Site 41RV208 is a prehistoric occupation containing a surface deposit of 12 lithic debitage, 6 flake tools, 6 cores, 2 groundstone fragments and 40 fire cracked rocks (FCR). The site is situated on a gravelly and deflated upland that forms the western rim of the Pecos River valley. Site 41RV209 consists of a prehistoric occupation containing a surface deposit of 12 FCR, 6 lithic debitage, 3 flake tools, 2 cores, 1 uniface, and 1 biface. This site is situated on the heavily eroded west bank of Salt Creek and has been disturbed by construction activities associated with an adjacent pipeline corridor. Site 41RV213 is an abandoned section of the Atchison, Topeka & Santa Fe (ATSF) Railway that parallels U.S. Highway 285 to the east. The section of railroad in the surveyed area has undergone extensive disturbance and consists of a narrow linear piling of fill, railroad gravels and non-descript metal debris. It is Halff’s recommendation that sites 41RV208, 41RV209 and 41RV213 are ineligible for National Register of Historic Places consideration in the surveyed area and no further cultural resources investigations are warranted for the project. While shovel testing within the lower terraces of the Pecos River valley floor resulted in negative findings, most of the shovel tests in this area did not encounter restrictive deposits soil or geologic deposits that antedate the Holocene. Therefore, the installation of the transmission line poles located along the lower alluvial terraces of the Pecos River was recommended for archeological monitoring. Halff recommends that construction of the remainder of the proposed transmission line route be allowed to proceed and that no additional archaeological investigations are recommended outside of the monitoring area. However, if the proposed transmission line route alignment changes, additional archeological survey may be necessary. In addition, should any cultural resources be discovered during the construction or maintenance activities associated with the project, work in the immediate area shall cease and the Texas Historical Commission be notified of the discovery

Isolating lithologic versus tectonic signals of river profiles to test orogenic models for the Eastern and Southeastern Carpathians

Fluvial morphology is affected by a wide range of forcing factors, which can be external, such as faulting and changes in climate, or internal, such as variations in rock hardness or degree of fracturing. It is a challenge to separate internal and external forcing factors when they are co-located or occur coevally. Failure to account for both factors leads to potential misinterpretations. For example, steepening of channel network due to lithologic contrasts could be misinterpreted to be a function of increased tectonic displacements. These misinterpretations are enhanced over large areas, where landscape properties needed to calculate channel steepness (e.g., channel concavity) can vary significantly in space. In this study, we investigate relative channel steepness over the Eastern Carpathians, where it has been proposed that active rock uplift in the Southeastern Carpathians (SEC) gives way N- and NW-wards to ca. 8 Myrs of post-orogenic quiescence. We develop a technique to quantify relative channel steepness, the relative steepness index, based on a wide range of concavities, and show that the main signal shows an increase in relative steepness index from east to west across the range. Rock hardness measurements and geological studies suggest this difference is driven by lithology. When we isolate channel steepness by lithology to test for ongoing rock uplift along the range, we find steeper channels in the south of the study area compared to the same units in the North. This supports interpretations from longer timescale geological data that active rock uplift is fastest in the southern SEC

Global projection of lead-zinc supply from known resources

© 2018 by the authors. Lead and zinc are used extensively in the construction and automotive industries, and require sustainable supply. In order to understand the future availability of lead and zinc, we have projected global supplies on a country-by-country basis from a detailed global assessment of mineral resources for 2013. The model GeRS-DeMo was used to create projections of lead and zinc production from ores, as well as recycling for lead. Our modelling suggests that lead and zinc production from known resources is set to peak within 15 years (lead 2025, zinc 2031). For lead, the total supply declines relatively slowly post peak due to recycling. If additional resources are found, these peaks would shift further into the future. These results suggest that lead and zinc consumers will need to plan for the future, potentially by: seeking alternative supplies (e.g., mine tailings, smelter/refinery slags); obtaining additional value from critical metals contained in lead-zinc ore deposits to counter lower grade ores; identifying potential substitutes; redesigning their products; or by contributing to the development of recycling industries

Establishment of novel neuroendocrine carcinoma patient-derived xenograft models for receptor peptide-targeted therapy

Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of neuroendocrine carcinomas (NECs) and neuroendocrine tumors (NETs), which have been increasing in incidence in recent years. Few cell lines and pre-clinical models exist for studying GEP NECs and NETs, limiting the ability to discover novel imaging and treatment modalities. To address this gap, we isolated tumor cells from cryopreserved patient GEP NECs and NETs and injected them into the flanks of immunocompromised mice to establish patient-derived xenograft (PDX) models. Two of six mice developed tumors (NEC913 and NEC1452). Over 80% of NEC913 and NEC1452 tumor cells stained positive for Ki67. NEC913 PDX tumors expressed neuroendocrine markers such as chromogranin A (CgA), synaptophysin (SYP), and somatostatin receptor-2 (SSTR2), whereas NEC1452 PDX tumors did not express SSTR2. Exome sequencing revealed loss o

Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: diagnosis in an expanded neonatal screening programme

The Expanded Newborn Screening Program (MS/MS) in the region of Galicia (NW Spain) was initiated in 2000 and includes the measurement of methionine levels in dried blood spots. Between June 2000 and June 2007, 140 818 newborns were analysed, and six cases of persistent hypermethioninaemia were detected: one homocystinuria due to cystathionine β-synthase (CβS) deficiency, and five methionine adenosyltransferase I/III (MAT I/III) deficiencies. The five cases of MAT I/III deficiency represent an incidence of 1/28 163 newborns. In these five patients, methionine levels in dried blood spots ranged from 50 to 147 μmol/L. At confirmation of the persistence of the hypermethioninaemia in a subsequent plasma sample, plasma methionine concentrations were moderately elevated in 4 of the 5 patients (mean 256 μmol/L), while total homocysteine (tHcy) was normal; the remaining patient showed plasma methionine of 573 μmol/L and tHcy of 22.8 μmol/L. All five patients were heterozygous for the same dominant mutation, R264H in the MAT1A gene. With a diet not exceeding recommended protein requirements for their age, all patients maintained methionine levels below 300 μmol/L. Currently, with a mean of 2.5 years since diagnosis, the patients are asymptomatic and show developmental quotients within the normal range. Our results show a rather high frequency of hypermethioninaemia due to MAT I/III deficiency in the Galician neonatal population, indicating a need for further studies to evaluate the impact of persistent isolated hypermethioninaemia in neonatal screening programmes

Vascular presentation of cystathionine beta-synthase deficiency in adulthood

Several recent studies describing a solely vascular presentation of cystathionine beta-synthase (CBS) deficiency in adulthood prompted us to analyze the frequency of patients manifesting with vascular complications in the Czech Republic. Between 1980 and 2009, a total of 20 Czech patients with CBS deficiency have been diagnosed yielding an incidence of 1:311,000. These patients were divided into three groups based on symptoms leading to diagnosis: those with vascular complications, with connective tissue manifestation and with neurological presentation. A vascular event such as a clinical feature leading to diagnosis of homocystinuria was present in five patients, while two of them had no other symptoms typical for CBS deficiency at the time of diagnosis. All patients with the vascular manifestation were diagnosed only during the past decade. The median age of diagnosis was 29 years in the vascular, 11.5 years in the connective tissue and 4.5 years in the neurological group. The ratio of pyridoxine responsive to nonresponsive patients was higher in the vascular (4 of 5 patients) and connective tissue groups (6 of 7 patients) than in the neurological group (2 of 8 patients). Mutation c.833T>C (p.I278T) was frequent in patients with vascular (6/10 alleles) and connective tissue presentation (8/14 alleles), while it was not present in patients with neurological involvement (0/16 alleles). During the last decade, we have observed patients with homocystinuria diagnosed solely due to vascular events; this milder form of homocystinuria usually manifests at greater ages, has a high ratio of pyridoxine responsiveness/nonresponsiveness, and the mutation c.833T>C (p.I278T) is often present

Employees’ feelings about more meetings: An overt analysis and recommendations for improving meetings

Purpose – The purpose of this paper is to identify how employees feel about having more meetings and what can be done to improve employees’ feelings about their work meetings. Design/methodology/approach – Data were obtained from three samples of working adults. The first was a convenience sample recruited by undergraduate students (n = 120), the second was a stratified random sample from a metropolitan area in the southern USA (n = 126), and the third was an internet-based panel sample (n = 402). Constant comparative analysis of responses to open-ended questions was used to investigate the overarching research questions. Findings – It is found that employees enjoy meetings when they have a clear objective, and when important relevant information is shared. Consistent with conservation of resources theory, most employees are unhappy with meetings when they reduce their work-related resources (e.g. meetings constrain their time, lack structure and are unproductive). Practical implications – The data suggest that meetings appear to be both resource-draining and resource-supplying activities in the workplace. Researchers and managers should consider overtly asking about how people feel about meetings, as a means of identifying areas for future research inquiry and targets for improvement in the workplace generally. Originality/value – The paper describes one of the few studies on meetings that ask the participants overtly what their feelings are regarding their workplace meetings. Additionally, the paper illustrates the usefulness of qualitative data analysis as a means for further understanding workplace activities viewing respondents as informants. Keywords United States of America, Employees behaviour, Employees attitudes, Employees participation, Meetings, Meeting demands, Qualitative research, Thematic analysi