Phage Therapy an Effective Remedy Against Drug-Resistant Bugs and Hard to Treat Bacterial Infections-A Review

The injudicious use of antibiotics not only in medicine but also to promote the growth of farm animals has led to the development of antibiotic resistance against many bacterial diseases. One of the remedy against such drug resistant bacterial infections is the application of phage (Bacteriophage) therapy. Phage therapy involves using phages or their products as bioagents for the treatment or prophylaxis of bacterial infections. There are two types of phages based on their type of life cycle: the lytic and the lysogenic phages. Only the lytic phages are used in phage therapy, because of the disadvantages of lysogenic pahges (Superinfection immunity, lysogenic conversion, specialized transduction). Apart from live phages the phage byproducts like phage lysins can also be used specifically against certain bacterial infections. The reports indicate that appropriate administration of living phages can be used to treat lethal infectious diseases caused by bacteria, like Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Salmonella spp. and Staphylococcus aureus etc. In the coming time the phage therapy will compensate for unavoidable complications of antimicrobial therapy, particularly the appearance of multidrug resistance bacteria (super bugs)

Polycystic Ovary Syndrome, a modern epidemic: An overview

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women, but can be very difficult to diagnose and treat due to vague presentation of symptoms and a lack of standardization in treatment. PCOS is characterized by hyperandrogenic manifestation like acne, hirsutism and chronic anovulation and is associated with metabolic derangement such as hyperlipidemia, hyperinsulinemia, insulin resistance and Type 2 diabetes mellitus.The cause of polycystic ovary syndrome is still unclear due to its multifactorial complexity; however, it has been observed and understood that there are several environmental and genetic factors, such as genetic variations like mutations and polymorphisms, differential regulation of genes, and pathways, may contribute to the pathogenesis of PCOS.The occurrence of considerable heterogeneity in clinical symptoms and endocrine features associated with PCOS implies that some women with Polycystic Ovaries on ultrasound scan may even exhibit none of the other features of PCOS.There is a spectacular increase in the prevalence of PCOS all over the world especially in Asia. The condition seems to be on a rise in Kashmir valley although systematic studies on the subject are still underway. In this review article, we will briefly provide an overview about the polycystic ovary syndrome. Keywords: Polycystic ovary syndrome, Genetic basis, clinical presentatio

Bioactive compounds from date fruit and seed as potential nutraceutical and functional food ingredients

Date palm is an important fruit bearing tree grown widely in the arid and semi-arid regions of the world. The date fruit and its by-products, such as seeds, have both nutritional and medicinal value. However, date fruit and seeds have not been fully considered as potential functional food ingredients to develop foods with promising health benefits. Based on the available information in the literature, fruit and seed of date palm are rich in phytochemicals, such as phenolics, anthocyanin, carotenoids, tocopherols, tocotrienols, phytosterols and dietary fiber. In addition, they were reported to possess several beneficial health properties explored under in-vitro and in-vivo conditions. Further research in this area would provide valuable information for the potential utilization of date fruit and seed as functional food ingredients. This review presents a comprehensive information about the bioactive compounds and nutraceutical properties of different varieties of date fruit and seed, as well as the potential for using them as functional food ingredients

Not Available

Not AvailableNot AvailableNot Availabl

Robot-Assisted Lung Biopsy: A Safer Approach to Lung Lesions

Purpose This article evaluates the feasibility, safety, and technical success of robot-assisted computed tomography (CT)-guided percutaneous lung biopsy