10 research outputs found
Wire Rope Defect Recognition Method Based on MFL Signal Analysis and 1D-CNNs
The quantitative defect detection of wire rope is crucial to guarantee safety in various application scenes, and sophisticated inspection conditions usually lead to the accurate testing of difficulties and challenges. Thus, a magnetic flux leakage (MFL) signal analysis and convolutional neural networks (CNNs)-based wire rope defect recognition method was proposed to solve this challenge. Typical wire rope defect inspection data obtained from one-dimensional (1D) MFL testing were first analyzed both in time and frequency domains. After the signal denoising through a new combination of Haar wavelet transform and differentiated operation and signal preprocessing by normalization, ten main features were used in the datasets, and then the principles of the proposed MFL and 1D-CNNs-based wire rope defect classifications were presented. Finally, the performance of the novel method was evaluated and compared with six machine learning methods and related algorithms, which demonstrated that the proposed method featured the highest testing accuracy (>98%) and was valid and feasible for the quantitative and accurate detection of broken wire defects. Additionally, the considerable application potential as well as the limitations of the proposed methods, and future work, were discussed
Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy
Dynamic therapy is attracting attention for cancer treatment. Here, the authors report that metal hydride nanodots can be used for sonodynamic therapy, which can be further enhanced by photothermal heating to increase tissue oxygenation
Bioorthogonal Coordination Polymer Nanoparticles with Aggregation-Induced Emission for Deep Tumor-Penetrating Radio- and Radiodynamic Therapy
10.1002/adma.202007888ADVANCED MATERIALS33
Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines
Abstract Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge. Herein, a transdermal delivery platform based on biocompatible fluorocarbon modified chitosan (FCS) is developed to achieve highly efficient non-invasive delivery of biomacromolecules including antibodies and antigens. The formed nanocomplexes exhibits effective transdermal penetration ability via both intercellular and transappendageal routes. Non-invasive transdermal delivery of immune checkpoint blockade antibodies induces stronger immune responses for melanoma in female mice and reduces systemic toxicity compared to intravenous injection. Moreover, transdermal delivery of a SARS-CoV-2 vaccine in female mice results in comparable humoral immunity as well as improved cellular immunity and immune memory compared to that achieved with subcutaneous vaccine injection. Additionally, FCS-based protein delivery systems demonstrate transdermal ability for rabbit and porcine skins. Thus, FCS-based transdermal delivery systems may provide a compelling opportunity to overcome the skin barrier for efficient transdermal delivery of bio-therapeutics
Synthesis of Hollow Biomineralized CaCO<sub>3</sub>–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity
The
development of activatable nanoplatforms to simultaneously
improve diagnostic and therapeutic performances while reducing side
effects is highly attractive for precision cancer medicine. Herein,
we develop a one-pot, dopamine-mediated biomineralization method using
a gas diffusion procedure to prepare calcium carbonate-polydopamine
(CaCO<sub>3</sub>–PDA) composite hollow nanoparticles as a
multifunctional theranostic nanoplatform. Because of the high sensitivity
of such nanoparticles to pH, with rapid degradation under a slightly
acidic environment, the photoactivity of the loaded photosensitizer,
i.e., chlorin e6 (Ce6), which is quenched by PDA, is therefore increased
within the tumor under reduced pH, showing recovered fluorescence
and enhanced singlet oxygen generation. In addition, due to the strong
affinity between metal ions and PDA, our nanoparticles can bind with
various types of metal ions, conferring them with multimodal imaging
capability. By utilizing pH-responsive multifunctional nanocarriers,
effective in vivo antitumor photodynamic therapy (PDT) can be realized
under the precise guidance of multimodal imaging. Interestingly, at
normal physiological pH, our nanoparticles are quenched and show much
lower phototoxicity to normal tissues, thus effectively reducing skin
damage during PDT. Therefore, our work presents a unique type of biomineralized
theranostic nanoparticles with inherent biocompatibility, multimodal
imaging functionality, high antitumor PDT efficacy, and reduced skin
phototoxicity