569 research outputs found
Análisis jurĂdico de las posibilidades de defensa de acuartelamientos de las Fuerzas Armadas ante ataques de la poblaciĂłn civil
Nutrients and Dietary Patterns Related to Osteoporosis
Osteoporosis is a common chronic disease characterized by a decrease in bone mineral
density, impaired bone strength, and an increased risk of fragility fractures. Fragility fractures are
associated with significant morbidity, mortality and disability and are a major public health problem
worldwide. The influence of nutritional factors on the development and progression of this disease
can be significant and is not yet well established. Calcium intake and vitamin D status are considered
to be essential for bone metabolism homeostasis. However, some recent studies have questioned the
usefulness of calcium and vitamin D supplements in decreasing the risk of fractures. The adequate
intake of protein, vegetables and other nutrients is also of interest, and recommendations have been
established by expert consensus and clinical practice guidelines. It is important to understand the
influence of nutrients not only in isolation but also in the context of a dietary pattern, which is a
complex mixture of nutrients. In this review, we evaluate the available scientific evidence for the
effects of the main dietary patterns on bone health. Although some dietary patterns seem to have
beneficial effects, more studies are needed to fully elucidate the true influence of diet on bone fragility.Instituto de Salud Carlos III
PI18/01235European Union (EU
Barrero RodrĂguez, Enrique: Derecho rendido y sociedad durmiente (Un ensayo desde el desencanto), PrĂłlogo de Rafael RodrĂguez Prieto, Editorial Betania, Madrid, 2020
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Foeniculum sanguineum Triano y A. Pujadas (Apiaceae) nueva especie del suroeste de la Región Mediterránea
Foeniculum sanguineum Triano & A. Pujadas, sp. nov., from the south western Mediterranean Region (Spain & Morocco) is described. Its characterization and a comparative study with the related species Foeniculum vulgare Mill., has been carried out through morphological, cytological, chemical and molecular analysis. F. sanguineum is distinguished primarily for its red petals, pink pollen in fresh, and red stylopod. It is a diploid species (2n= 22). A high proportion of limonene and piperitenone oxide (absent in F. vulgare) has been found in the essential oil composition of the dry fruits of F. sanguineum and a high amount (about 50 %) of α-phellandrene in its roots and stems. Phylogenetic analyses were performed using the internal transcribed spacer sequences of nuclear ribosomal DNA (ITS) and the chloroplast rbcL gene sequences. ITS analysis supports the existence of the new species, while revealing sequence divergence both at the intraspecific and at the interspecific levels. A Single-nucleotide-polymorphism (SNP) sequence divergence found in the slow evolving chloroplast gene provided additional support for the novel species characterization, for which the name Foeniculum sanguineum is proposed
An open source framework based on Kafka-ML for Distributed DNN inference over the Cloud-to-Things continuum
The current dependency of Artificial Intelligence (AI) systems on Cloud computing implies higher transmission latency and bandwidth consumption. Moreover, it challenges the real-time monitoring of physical objects, e.g., the Internet of Things (IoT). Edge systems bring computing closer to end devices and support time-sensitive applications. However, Edge systems struggle with state-of-the-art Deep Neural Networks (DNN) due to computational resource limitations. This paper proposes a technology framework that combines the Edge-Cloud architecture concept with BranchyNet advantages to support fault-tolerant and low-latency AI predictions. The implementation and evaluation of this framework allow assessing the benefits of running Distributed DNN (DDNN) in the Cloud-to-Things continuum. Compared to a Cloud-only deployment, the results obtained show an improvement of 45.34% in the response time. Furthermore, this proposal presents an extension for Kafka-ML that reduces rigidness over the Cloud-to-Things continuum managing and deploying DDNN
Obesity and Bone Health: A Complex Relationship
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old paradigm
that obese patients were more protected than those with normal weight. Specifically, in older subjects
in whom there is a redistribution of fat from subcutaneous adipose tissue to visceral adipose tissue and
an infiltration of other tissues such as muscle with the consequent sarcopenia, obesity can accentuate
the changes characteristic of this age group that predisposes to a greater risk of falls and fractures.
Other factors that determine a greater risk in older subjects with obesity are chronic proinflammatory
status, altered adipokine secretion, vitamin D deficiency, insulin resistance and reduced mobility. On
the other hand, diagnostic tests may be influenced by obesity and its comorbidities as well as by body
composition, and risk scales may underestimate the risk of fractures in these patients. Weight loss
with physical activity programs and cessation of high-fat diets may reduce the risk. Finally, more
research is needed on the efficacy of anti-osteoporotic treatments in obese patients.Instituto de Salud Carlos IIIEuropean Commission CD20/00022
PI18-00803
PI21-01069
PI18-01235European CommissionJunta de Andalucia PI-0268-201
RevisiĂłn de la evidencia cientĂfica sobre uso clĂnico del Trabecular Bone Score (TBS). Posiciones oficiales de la SEIOMM (2018)
La incorporaciĂłn de nuevas aplicaciones tecnolĂłgicas en el campo mĂ©dico conlleva un prolongado periodo de valoraciĂłn de la evidencia cientĂfica que se va generando en el proceso de validaciĂłn clĂnica.
En los últimos 5 años se han generado múltiples publicaciones, comunicaciones en congresos
y reuniones de sociedades cientĂficas. La aplicaciĂłn del Trabecular Bone Score (TBS) ha recibido tambiĂ©n la atenciĂłn de la Sociedad Internacional de DensitometrĂa ClĂnica (The International Society for Clinical Densitometry -ISCD-) que la ha incorporado a sus posiciones oficiales
Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice
This research was funded by the Institute of Health Carlos III grants (PI18-00803 and PI18-01235), co-funded by the European Regional Development Fund (FEDER) and Junta de Andalucia (PI-0268-2019). In addition, V.C.-B. and C.G.-F. are funded by postdoctoral fellowships from the Junta de Andalucia and Institute of Health Carlos III respectively (RH-0141-2020; CD20/00022).Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extraskeletal
activity. In this context, vitamin D seems to be involved in infections, autoimmune diseases,
cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin
D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D)
levels appear to be associated with most of the insulin resistance disorders described to date. In fact,
vitamin D deficiency may be one of the factors accelerating the development of insulin resistance.
Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis
of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS)
and polycystic ovary syndrome (PCOS). An important question is the identification of 25(OH)D levels
capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of
developing insulin resistance related disorders. The benefits of 25(OH)D supplementation/repletion
on bone health are well known, and although there is a biological plausibility linking the status of
vitamin D and insulin resistance supported by basic and clinical research findings, well-designed
randomized clinical trials as well as basic research are necessary to know the molecular pathways
involved in this association.Institute of Health Carlos III grants PI18-00803
PI18-01235European Commission
Junta de Andalucia PI-0268-2019Instituto de Salud Carlos III RH-0141-2020
CD20/0002
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