22,597 research outputs found

    La construcción social del amor con base en la estación de radio “Amor 92.5” Toluca

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    En resumen, nos enfocaremos –dentro de la comunicaciĂłn- a analizar el discurso amoroso de los radioescuchas del programa ―CuĂ©ntame tu Historia, los cuĂĄles tambiĂ©n son usuarios de las redes sociales, esto con el fin de saber cuĂĄles son las conceptualizaciones amorosas de estas personas porque de esta manera podremos saber quĂ© tanto los medios de comunicaciĂłn son una herramienta de control esencial para la construcciĂłn de significados sobre el amo

    Agents intentionality, capabilities and the performance of Systems of Innovation

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    We are interested on why and how an economic system evolves and, in particular, on the causes of the differences across systems of innovation (SI). SI’s performance differs substantially because there are specific causes at work, apart from the differences in the underlying technologies, institutions, etc. In particular, we refer to the intentionality of the agents interacting within a system for innovation to find out the relationship between agents’ goals, SI’s performance and its policy implications. The underlying thesis in this paper is that agent intentionality is a necessary condition for a substantive explanation of the dynamism of any socio-economic system. The paper departs from an abstract definition of a system as a set of constitutive elements and the connections among them serving a common purpose. And explores how intentionality shapes the structure, evolution and performance of an SI. In this context an evolutionary efficiency criterion is proposed.systems of innovation; intentionality; evolving capabilities; evolutionary efficiency.

    Action Plans and Socio-Economic Evolutionary Change

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    An important challenge to evolutionary economics consists of how to tackle with the dramatic tension between purposeful human action and the ‘blindness’ of evolutionary processes. On the one hand, economic action, if rational, has to be planned (which implies purposeful ordering of the means used to achieve objectives). On the other hand, an evolutionary process involves both the emergence of novelties (both intended innovations and unintended consequences of actions) and properties that manifest at meso and macro levels. Some recent papers have insisted on these issues. However, few analytical tools are yet available to cope with both, the analysis of intended dynamic action and ‘blind’ evolution. In this paper we propose the so-called ‘action plan approach’, a theoretical framework which could be useful for this task. The development of tools that permit us to analyze how individuals construct their plans, the projective (conjectural) and interactive nature of action, and the learning processes involved in ‘planning and acting’, may help us identifying and understanding new sources of complexity of economic processes. The close relationship of the ‘action plan approach’ with other systemic conceptual approaches is also highlighted.connections, action plans; novelty; intentionality; evolutionary economic process

    Broadband transverse susceptibility in multiferroic Y-type hexaferrite Ba0.5Sr1.5Zn2Fe12O22

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    ProducciĂłn CientĂ­ficaNoncollinear spin systems with magnetically induced ferroelectricity from changes in spiral magnetic ordering have attracted significant interest in recent research due to their remarkable magnetoelectric effects with promising applications. Single phase multiferroics are of great interest for these new multifunctional devices, being Y-type hexaferrites good candidates, and among them the ZnY compounds due to their ordered magnetic behaviour over room temperature. Polycrystalline Y type hexaferrites with composition Ba0.5Sr1.5Zn2Fe2O22 (BSZFO) were sintered in 1050 °C–1250 °C temperature range. Transverse susceptibility measurements carried out on these BSZFO samples in the temperature range 80–350 K with DC fields up to ± 5000 Oe reveal different behaviour depending on the sintering temperature. Sample sintered at 1250 °C is qualitatively different, suggesting a mixed Y and Z phase like CoY hexaferrites. Sintering at lower temperatures produce single phase Y-type, but the transverse susceptibility behaviour of the sample sintered at 1150 °C is shifted at temperatures 15 K higher. Regarding the DC field sweeps the observed behaviour is a peak that shifts to lower values with increasing temperature, and the samples corresponding to single Y phase exhibit several maxima and minima in the 250 K–330 K range at low DC applied field as a result of the magnetic field induced spin transitions in this compound.Ministerio de Ciencia, InnovaciĂłn y Universidades; Agencia Estatal de InvestigaciĂłn with FEDER (MAT2016-80784-P

    Synthesis, structural characterization and broadband ferromagnetic resonance in Li ferrite nanoparticles

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    Producción CientíficaLithium ferrites are well known materials due to its numerous technological applications especially in microwave devices. Lithium ferrite nanoparticles were prepared by sol-gel technique by means of Pechini method, and then annealed at different temperatures in 250–1000 °C range. XRD confirms spinel formation with particles sizes in 15–700 nm range, with increased size with annealing temperature, whereas FTIR and Raman measurement confirm that single phase lithium ferrite with ordered cationic structure is obtained. Microwave magnetoabsorption data of the annealed lithium ferrite nanoparticles were obtained with a broadband system based on a network analyzer that operates up to 8.5 GHz. At fields up to 200 mT we can observe a broad absorption peak that shifts to higher frequencies with magnetic field according to ferromagnetic resonance theory. The amplitude of absorption, up to 85%, together with the frequency width of about 5.5 GHz makes this material suitable as wave absorber. FMR parameters like resonance field, linewidth and broadening are analyzed in order to obtain the characteristic parameters and analyze the microwave behaviour.Ministerio de Economía, Industria y Competitividad ( project MAT2016-80784-P

    Downsizing implementation and financial performance

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    In the present study we explore the relationship between downsizing decisions and corporate financial performance after top management has decided to downsize. Our focus is on the financial consequences arising from the amount of downsizing and the use of disengagement incentives. For this purpose, we use a sample of downsizing announcements in the Spanish press from 1995 up to 2001. Although the results show that the amount of downsizing is not significantly related to post-downsizing profitability, the evidence provided supports the finding that the use of disengagement incentives (which motivate workers to leave the organization) is negatively related to firm performance. Our analysis helps to understand the role that strategic downsizing decisions play in explaining observed variance in the performance of downsized firms. Thus, it advances scholarly organizational research by reinforcing the concept that corporate performance is not only contingent on strategies, but also influenced by the means through which these strategies are implemented

    Does downsizing improve organizational performance? An analysis of Spanish manufacturing firms

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    The objective of this study is to examine the effect of downsizing on corporate performance, considering a sample of manufacturing firms drawn from the Spanish Survey of Business Strategies during the 1993- 2005 period. No significant differences in post-downsizing performance arise between companies which downsize and those that do not. Likewise, we find that substantial workforce reductions through collective dismissals do not either lead to improved performance levels. Downsizing, therefore, may not be a way for managers to increase performance, particularly in a context like the Spanish one, where the labour market is characterized by a high protection of employees’ rights and substantial contract termination costs

    c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity

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    This is an open access article distributed under the Creative Commons Attribution License.-- et al.Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (JNK) plays a crucial role. With a view to optimizing clinical use of plitidepsin, we have therefore evaluated the possibility of using JNK activation as an in vivo biomarker of response. In this study, we show that administration of a single plitidepsin dose to mice xenografted with human cancer cells does indeed lead to increased phosphorylation of JNK in tumors at 4 to 12 h. By contrast, no changes were found in other in vitro plitidepsin targets such as the levels of phosphorylated-ERK, -p38MAPK or the protein p27KIP1. Interestingly, plitidepsin also increased JNK phosphorylation in spleens from xenografted mice showing similar kinetics to those seen in tumors, thereby suggesting that normal tissues might be useful for predicting drug activity. Furthermore, plitidepsin administration to rats at plasma concentrations comparable to those achievable in patients also increased JNK phosphorylation in peripheral mononuclear blood cells. These findings suggest that changes in JNK activity provide a reliable biomarker for plitidepsin activity and this could be useful for designing clinical trials and maximizing the efficacy of plitidepsin.This work has been partially supported by grants (Programa Cenit, CEN-20091016, SAF2010-18302 and Fondo Europeo de Desarrollo Regional-Instituto de Salud Carlos III, RD12/0036/0021) from Ministerio de EconomĂ­a y Competitividad of Spain.Peer Reviewe
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