A novel Island Model based on Coral Reefs Optimization algorithm for solving the unequal area facility layout problem

This paper proposes a novel approach to address the Unequal Area Facility Layout Problem (UA-FLP), based on the combination of both an Island Model and a Coral Reefs Optimization (CRO) algorithm. Two different versions of this Island Model based on Coral Reefs Optimization Algorithm (IMCRO) are proposed and applied to the UA-FLP. The structure of flexible bays has been selected as effective encoding to represent the facility layouts within the algorithm. The two versions of the proposed approach have been tested in 22 UA-FLP cases, considering small, medium and large size categories. The empirical results obtained are compared with previous state of the art algorithms, in order to show the performance of the IMCRO. From this comparison, it can be extracted that both versions of the proposed IMCRO algorithm show an excellent performance, accurately solving the UA-FLP instances in all the size categories

Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

Erosión y desertificación.-Valorización de purines de cerdo en rehabilitación de espacios mineros: ensayos en condiciones de campo

ABSTRACT The intense mining activity carried out in Cartagena-La Unión Mountain, in Murcia region, has provoked extremely high accumulation of heavy metals in the environment. Due to the absence of vegetation cover, these soils are very liable to erosion, either wind or water, and they represent the major source of heavy metals pollution for the local environment due to dust blow and leaching of the results of mineral weathering into nearby watercourses. After 4 years of experiments in plots (4 m2), it has been demonstrated the potential use of pig manure to rehabilitate degraded and polluted soils, increasing carbon content and nutrients, promoting aggregates stability, decreasing mobility of heavy metals and establishing plant cover. In this study we pretend to extrapolate the results obtained in these plot previous experiments to field large scale scenarios using pig manure to amend the polluted soil and phytostabilization technique with native species in order to allow spontaneous colonization by plants and minimise the risks associated to those mining areas

Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis

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Consequence of a unbalanced diet in horses: preliminary study

A study was made of the diet employed on a Spanish horse-breeding farm, 11 necropsies and blood samples from 18 other horses were analyzed and viewed alongside handling and exercise practice.Se aportan los datos del régimen alimenticio de una explotación de caballos de raza española, de la necropsia de 11 caballos y de la analítica sanguínea de otros 18 équidos; todo ello en relación con el manejo y ejercicio realizado. Un exceso de hidratos de carbono en la dieta puede originar, paulatinamente, degeneración grasa en el hígado, lo cual redunda no sólo en los costes económicos de la explotación sino también en la salud y apreciación del colectivo

Consecuencias de una dieta desequilibrada en équidos: estudio preliminar

Se aportan los datos del régimen alimenticio de una explotación de caballos de raza española, de la necropsia de 11 caballos y de la analítica sanguínea de otros 18 équidos; todo ello en relación con el manejo y ejercicio realizado. Un exceso de hidratos de carbono en la dieta puede originar, paulatinamente, degeneración grasa en el hígado, lo cual redunda no sólo en los costes económicos de la explotación sino también en la salud y apreciación del colectivo.A study was made of the diet employed on a Spanish horse-breeding farm, 11 necropsies and blood samples from 18 other horses were analyzed and viewed alongside handling and exercise practice

Tract-specific damage at spinal cord level in pure hereditary spastic paraplegia type 4: a diffusion tensor imaging study.

SPG4 is a subtype of hereditary spastic paraplegia (HSP), an upper motor neuron disorder characterized by axonal degeneration of the corticospinal tracts and the fasciculus gracilis. The few neuroimaging studies that have focused on the spinal cord in HSP are based mainly on the analysis of structural characteristics. We assessed diffusion-related characteristics of the spinal cord using diffusion tensor imaging (DTI), as well as structural and shape-related properties in 12 SPG4 patients and 14 controls. We used linear mixed effects models up to T3 in order to analyze the global effects of 'group' and 'clinical data' on structural and diffusion data. For DTI, we carried out a region of interest (ROI) analysis in native space for the whole spinal cord, the anterior and lateral funiculi, and the dorsal columns. We also performed a voxelwise analysis of the spinal cord to study local diffusion-related changes. A reduced cross-sectional area was observed in the cervical region of SPG4 patients, with significant anteroposterior flattening. DTI analyses revealed significantly decreased fractional anisotropy (FA) and increased radial diffusivity at all the cervical and thoracic levels, particularly in the lateral funiculi and dorsal columns. The FA changes in SPG4 patients were significantly related to disease severity, measured as the Spastic Paraplegia Rating Scale score. Our results in SPG4 indicate tract-specific axonal damage at the level of the cervical and thoracic spinal cord. This finding is correlated with the degree of motor disability