An open hardware electronic controller for motorized rotary injection valves used in flow injection analysis

This work presents the design, development and the implementation of a motorized injection valve used in Flow Injection Analysis systems. The built prototype has been developed based on the open hardware, software and firmware, emergent philosophy thus helping the development of a free and independent science. This policy creates a platform of open projects that feed each other, contributing to scientific and technological development while sharing knowledge. The proposed design project can be modified to implant it in other devices or projects according to the needs of each one. Also, the open project can be a great help as teaching material in Universities, since open hardware projects are fully described and documented

Composición Arquitectónica 5 y 6

La presente Memoria culmina el trabajo colaborativo del área de conocimiento de Composición Arquitectónica por lo que respecta a las materias de Grado en (Fundamentos en) Arquitectura, al haber definido sus contenidos, sus métodos de aprendizaje y sus sistemas de evaluación para el conjunto de la titulación. Ahora se concretan las dos últimas asignaturas de 5º curso: CA5 y CA6. Por un lado está CA5, cuyo eje fundamental es la definición de criterios para el ejercicio de la crítica de arquitectura, una vez que se ha construido una base de información histórica y teórica en los estudiantes a lo largo de cuatro cursos. Una crítica entendida tanto como sistema de contextualización sobre las obras ejecutadas (del presente o del pasado) y, a la vez, como marco de referencia para someter a evaluación las soluciones que se proponen desde proyecto (desde el presente hacia el futuro). Así pues, crítica entendida como herramienta de análisis tanto como de prospección. Por otro lado está CA6, en la que el eje fundamental es la intervención sobre el patrimonio arquitectónico, sea o no monumental, entendido como una realidad ineludible pues gran parte del trabajo de los arquitectos transita sobre preexistencias en sus muy diversos grados

A note on supersymmetric Yang-Mills thermodynamics

The thermodynamics of supersymmetric Yang-Mills theories is studied by computing the two-loop correction to the canonical free energy and to the equation of state for theories with 16, 8 and 4 supercharges in any dimension $4\leq d\leq 10$, and in two dimensions at finite volume. In the four-dimensional case we also evaluate the first non-analytic contribution in the 't Hooft coupling to the free energy, arising from the resummation of ring diagrams. To conclude, we discuss some applications to the study of the Hagedorn transition in string theory in the context of Matrix strings and speculate on the possible physical meaning of the transition.Comment: 19 pages, harvmac, epsf. 1 figure included. Minor changes: typos corrected; references, a footonote and a note adde

Duality in Non-Trivially Compactified Heterotic Strings

We study the implications of duality symmetry on the analyticity properties of the partition function as it depends upon the compactification length. In order to obtain non-trivial compactifications, we give a physical prescription to get the Helmholtz free energy for any heterotic string supersymmetric or not. After proving that the free energy is always invariant under the duality transformation $R\rightarrow \alpha^{'}/(4R)$ and getting the zero temperature theory whose partition function corresponds to the Helmholtz potential, we show that the self-dual point $R_{0}=\sqrt{\alpha^{'}}/2$ is a generic singularity as the Hagedorn one. The main difference between these two critical compactification radii is that the term producing the singularity at the self-dual point is finite for any $R \neq R_{0}$. We see that this behavior at $R_{0}$ actually implies a loss of degrees of freedom below that point.Comment: (Preprint No. FTUAM-92/12) 17 page

Lattice Perturbation Theory in Noncommutative Geometry and Parity Anomaly in 3D Noncommutative QED

We formulate lattice perturbation theory for gauge theories in noncommutative geometry. We apply it to three-dimensional noncommutative QED and calculate the effective action induced by Dirac fermions. In particular "parity invariance" of a massless theory receives an anomaly expressed by the noncommutative Chern-Simons action. The coefficient of the anomaly is labelled by an integer depending on the lattice action, which is a noncommutative counterpart of the phenomenon known in the commutative theory. The parity anomaly can also be obtained using Ginsparg-Wilson fermions, where the masslessness is guaranteed at finite lattice spacing. This suggests a natural definition of the lattice-regularized Chern-Simons theory on a noncommutative torus, which could enable nonperturbative studies of quantum Hall systems.Comment: 31 pages. LaTeX, feynmf. Minor changes, references added and typos corrected. Final version published in JHE

microRNA Expression and Its Association With Disability and Brain Atrophy in Multiple Sclerosis Patients Treated With Glatiramer Acetate.

Background: MicroRNAs are small non-coding RNA that regulate gene expression at a post-transcriptional level affecting several cellular processes including inflammation, neurodegeneration and remyelination. Different patterns of miRNAs expression have been demonstrated in multiple sclerosis compared to controls, as well as in different courses of the disease. For these reason they have been postulated as promising biomarkers candidates in multiple sclerosis. Objective: To correlate serum microRNAs profile expression with disability, cognitive functioning and brain volume in patients with remitting-relapsing multiple sclerosis. Methods: Cross-sectional study in relapsing-remitting multiple sclerosis patients treated with glatiramer acetate. Disability was measured with Expanded Disability Status Scale (EDSS) and cognitive function was studied with Symbol Digit Modalities Test (SDMT). Brain volume was analyzed with automatic software NeuroQuant® . Results: We found an association between miR.146a.5p (rs:0.434, p=0.03) and miR.9.5p (rs:0.516, p=0.028) with EDSS; and miR-146a.5p (rs:-0.476, p=0.016) and miR-126.3p (rs:-0.528, p=0.007) with SDMT. Regarding to the brain volume, miR.9.5p correlated with thalamus (rs:-0.545, p=0.036); miR.200c.3p with pallidum (rs:-0.68, p=0.002) and cerebellum (rs:-0.472, p=0.048); miR-138.5p with amygdala (rs:0.73, p=0.016) and pallidum (rs:0.64, p=0.048); and miR-223.3p with caudate (rs:0.46, p=0.04). Conclusions: These data support the hypothesis of microRNA as potential biomarkers in this disease. More studies are needed to validate these results and to better understand the role of microRNAs in the pathogenesis, monitoring and therapeutic response of multiple sclerosis.post-print1410 K

Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

The transient outward potassium current (Itof) is generated by the activation of KV4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by KV4.3/KChIP2, KV4.3/KChIP2/DPP6 and KV4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (KV4.3/KChIP2, KV4.3/KChIP2/DPP6 or KV4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreased the maximum peak of KV4.3/KChIP2, KV4.3/KChIP2/DPP6 and KV4.3/KChIP2/KCNE2 currents, slowing their time course of inactivation in a concentration-, voltage-, time- and use-dependent manner. IQM-266 produced an increase in the charge in KV4.3/KChIP2 channels that was intensified when DPP6 was present and abolished in the presence of KCNE2. IQM-266 induced an activation unblocking effect during the application of trains of pulses to cells expressing KV4.3/KChIP2 and KV4.3/KChIP2/KCNE2, but not in KV4.3/KChIP2/DPP6 channels. Overall, all these results are consistent with a preferential IQM-266 binding to an active closed state of Kv4.3/KChIP2 and Kv4.3/KChIP2/KCNE2 channels, whereas in the presence of DPP6, IQM-266 binds preferentially to an inactivated state. In conclusion, DPP6 and KCNE2 modify the pharmacological response of KV4.3/KChIP2 channels to IQM-266

Graviton emission in Einstein-Hilbert gravity

The five-point amplitude for the scattering of two distinct scalars with the emission of one graviton in the final state is calculated in exact kinematics for Einstein-Hilbert gravity. The result, which satisfies the Steinmann relations, is expressed in Sudakov variables, finding that it corresponds to the sum of two gauge invariant contributions written in terms of a new two scalar - two graviton effective vertex. A similar calculation is carried out in Quantum Chromodynamics (QCD) for the scattering of two distinct quarks with one extra gluon in the final state. The effective vertices which appear in both cases are then evaluated in the multi-Regge limit reproducing the well-known result obtained by Lipatov where the Einstein-Hilbert graviton emission vertex can be written as the product of two QCD gluon emission vertices, up to corrections to preserve the Steinmann relations.Comment: 28 pages, LaTeX, feynmf. v2: typos corrected, reference added. Final version to appear in Journal of High Energy Physic

Bosonic D-branes at finite temperature with an external field

Bosonic boundary states at finite temperature are constructed as solutions of boundary conditions at $T\neq 0$ for bosonic open strings with a constant gauge field $F_{ab}$ coupled to the boundary. The construction is done in the framework of thermo field dynamics where a thermal Bogoliubov transformation maps states and operators to finite temperature. Boundary states are given in terms of states from the direct product space between the Fock space of the closed string and another identical copy of it. By analogy with zero temperature, the boundary states heve the interpretation of $Dp$-brane at finite temperature. The boundary conditions admit two different solutions. The entropy of the closed string in a $Dp$-brane state is computed and analysed. It is interpreted as the entropy of the $Dp$-brane at finite temperature.Comment: 21 pages, Latex, revised version with minor corrections and references added, to be published in Phys. Rev.