Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking.

Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-a, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking. 103 subjects entered the study including 61 new diagnosed pulmonary TB patients (23 smokers and 38 nonsmokers) and 42 control healthy subjects. The phagocytosis of fluorescein isothiocyanate dextran (FITC-dextran) in blood monocytes/macrophages through flowcytometry was assessed. Serum levels of TNF-a and CXCL-8 were analyzed by ELISA methods. A lower percentage of cells from TB patients who smoked [50.29% (43.4-57.2), p<0.01] took up FITC-dextran after 2h compared to non-smoking TB subjects [71.62% (69.2-74.1)] and healthy cases [97.45% (95.9-99.1). Phagocytic capacity was inversely correlated with cigarette smoking as measured by pack years (r=-0.73, p<0.001). The serum levels of TNF-a and CXCL-8 were significantly higher in the TB patients who smoked compared to the TB non-smoker group (p<0.001, p<0.01 respectively). Blood monocytes/macrophages from TB patients have reduced phagocytic capacity which is further reduced in TB patients who smoke. Smoking enhanced serum levels of TNF-a and CXCL-8 suggesting a greater imbalance between the proinflammatory and anti-inflammatory factors in these patients

Inter-simple sequence repeats (ISSR) and morphological diversity in Onosma L. (Boraginaceae) species in Iran

Morphological characteristics as well as inter-simple sequence repeats (ISSR) molecular markers were used to study the species relationship in Onosma species (Boraginaceae) in Iran. Principal component analysis (PCA) showed that morphological characters like caule leaf size and shape, bract shape, corolla shape, nutlet length, venation and corolla teeth size and anther length are the most variable morphological characters among Onosma species studied. Out of 17 ISSR primers used, 6 primers produced 41 polymorphic and reproducible bands. Few specific ISSR bands were obtained for the species studied which show genetic material change during species diversification. Such bands may be used in the species identification too. Morphological and molecular trees obtained partly agreed with each other. In both trees, Onosma dasytrichum and Onosma microcarpum are placed close to each other, Onosma procerum and Onosma pachypodum show affinity to each other and Onosma araraticum, Onosma bodeanum, Onosma bistonensis, Onosma stenosiphon and  Onosma bulbotrichum are placed close to each other while, Onosma rostellatum stands far from the other species. The combined morphological and ISSR tree obtained separated the members of three sections of Onosma, Podnosma and Protonosma from each other. Moreover, almost a good separation of different subsections in the section Onosma was observed in the combined tree.Key words: Inter-simple sequence repeats, morphometry, Onosma

Association of dietary patterns with continuous metabolic syndrome in children and adolescents; A nationwide propensity score-matched analysis: The CASPIAN-V study

Objective: This study aims to determine the association of dietary patterns with metabolic syndrome (MetS) and its components in children and adolescents. Methods: This nationwide study was conducted in 2015 among 4200 students aged 7-18 years, who lived in 30 provinces in Iran. The analysis was conducted based on the propensity score using a matched case-control study design. Three dietary patterns were obtained conducting a principal component analysis with a varimax rotation on 16 dietary groups. Continuous MetS score was computed by standardizing the residuals (z-scores) of MetS components by regressing them according to age and sex. The gold standard diagnosis of MetS was considered based on the International Diabetes Federation criteria. Moreover, for the purpose of data analysis, matched logistics analysis was used. Results: The study participants consisted of 3843 children and adolescents (response rate 91.5) with mean (SD) age of 12.45 (3.04) years. Totally 49.4 of students were girls and 71.4 lived in urban areas. Three dietary patterns were obtained: Healthy, Western, and Sweet. Prevalence of MetS was 5 (boy 5.5 and girl 4.5). Results of multivariate analysis show that students with Sweet dietary patterns were at higher risk for abdominal obesity (OR 1.29; 95 CI 1.01-1.66), elevated blood pressure (OR 1.35; 95 CI 1.01-1.81) and MetS (OR 1.33; 95 CI 1.02-1.74). The two other dietary patterns were not associated with MetS and its components. Conclusion: Sweet dietary pattern increase the risk of MetS and some its components in Iranian children and adolescents. This finding provides valuable information for effective preventive strategies of MetS based on diet rather than medication to maintain healthy lifestyle habits. © 2018 The Author(s)

Economic inequality in prevalence of underweight and short stature in children and adolescents: The weight disorders survey of the caspian-IV study

Objective: The aim of this study was to determine the determinants of socio-economic inequality in the prevalence of short stature and underweight in Iranian children and adolescents. Subjects and methods: This cross-sectional nationwide study was conducted on 36,486 participants, aged 6-18 years. This school-based surveillance (CASPIAN-IV) program and its complementary part on weight disorders evaluation was conducted in urban and rural areas of 30 provinces in Iran. In addition to physical examination, a validated questionnaire was completed from students and their parents. Socio-economic status (SES) was determined using principal component analysis, and was classified in quintile scale. Inequality in the prevalence of underweight and short stature was assessed using concentration (C) index and slop index of inequality (SII) by the Oaxaca-Blinder decomposition method. Results: The prevalence (95 CI) of underweight and short stature at national level was 10.89 (10.55, 11.23) and 4.15 (3.94, 4.38), respectively; it had a downtrend from the lowest to highest SES quintile. Furthermore, the value of C for underweight and short stature was negative, i.e. inequality was in favor of high SES groups. Moreover, the prevalence gap of underweight and short stature in the first and fifth quintiles of SES was 6.58 and 5.80, respectively. The highest proportion of this gap was explained by living area. In the multiple logistic model, odds of underweight and short stature were significantly lower in individuals with higher SES. Compared to boys, odds of underweight were decreased in girls, whereas odds of short stature were increased in them. Odds of underweight and short stature were increased in participants from rural areas than in urban areas. With increasing age, the odds of underweight and short stature decreased significantly. Conclusions: The results of this study showed that inequality in the prevalence of short stature and underweight was in favor of high SES groups. Moreover, living area was one of the most important determinants that explained this inequality. Therefore, this issue needs to be considered in health promotion policies. © 2020, Sociedade Brasileira de Endocrinologia e Metabologia. All rights reserved

Women's right to health in Iran

In Iran, discrimination based on gender in enjoyment of the right to health is prohibited. Making health services physically and financially accessible to the entire population and removing social and cultural barriers of women's access to health services are main considerations of the health law sand policies of Iran. The health of Iranian women has improved considerably in recent years. But there are disparities in health status and access of women to health services around the country. Some groups of women, including the poor, the elderly, the disabled, the illegal immigrant, and those without an appropriate male guardian, and rural women have limited access to health services in Iran. To realize women's right to health, this country should immediately remove the disparities and use all the necessary means including legislative, administrative, budgetary, promotional,and judicial measures. National plans on women's empowerment and support should be interpreted in provincial pro-grams and action plans. Moreover, a monitoring system and certain benchmarks for tracing the progress of the plans should be established. Realizing other economic, social,and cultural rights including the rights to food, shelter, education, work, social security, and participation in society will improve the Iranian women's enjoyment of their right

Hydrogen and Combined Heat and Power Production from the Steam Gasification of Plastic Wastes. An Experimental and Modelling Analysis Including Techno-Economic and Environmental Assessment

In this work a modular high temperature (850°C to 1150°C) steam gasification process (DMG®) for production of hydrogen, to be used mainly as a clean fuel in the transport system, and combined heat and power production from mixed unrecyclable plastic wastes is studied which is being developed for commercial production by Powerhouse Energy group (PHE). This includes experiments, process modelling, techno-economic and environmental assessments. Three main scenarios were defined for the process operating conditions which include production of 2 tonnes per day (TPD) hydrogen as the first scenario, the second scenario for maximum conversion of the carbon content of the feedstock to gas products, and the third scenario for the maximum hydrogen production. It should be noted that in the second scenario the maximum conversion of the carbon content of the feedstock may not be necessarily 100% conversion, or it may not be possible in a self-sustained process (in terms of energy). Therefore, this scenario is investigated to identify the possible process conditions and outputs for this scenario. An Aspen Plus model was developed for the process and was further calibrated and validated using experimental data obtained from a pilot-scale unit. The model was used for sensitivity analysis for a commercial unit with 35 TPD feed capacity based on the design capacity of the first commercial unit. The modelling results are used to define the optimum process conditions in each defined scenario. Then, each scenario was defined in the developed model for four process temperatures of 850°C, 950°C, 1050°C, and 1150°C. The results from process modelling including mass and energy balance are used for techno-economic analysis and environmental assessments. In techno-economic analysis, three approaches are considered, including fixed sale prices for all products and by-products, considering electricity sale price to domestic, and non-domestic customers, and performing economic evaluation of the process for all scenarios. In the environmental assessment two alternatives of landfilling and incineration to DMG® are defined and the greenhouse gas (GHG) emissions from each alternative are assessed for the same capacity and a comparison between the alternatives are made. Finally, the optimum process condition and sale strategy for the main products are suggested. Based on the results of the performed analyses, it was concluded that using the DMG® technology for production of hydrogen, electricity and heat can be economically viable and that hydrogen with a competitive sale price in compare with hydrogen produced from the available alternative technologies in the market can be produced. Also, it was concluded that DMG® has less environmental impacts in terms of GHG emissions than those from incineration, and considering the plans for banning landfilling of plastic wastes, DMG® can be a good alternative. The specific results are discussed in the result and discussion section and summarised in the conclusion chapter