590 research outputs found
Atmospheric extinction coefficients in the band for several major international observatories: Results from the BiSON telescopes, 1984 to 2016
Over 30 years of solar data have been acquired by the Birmingham Solar
Oscillations Network (BiSON), an international network of telescopes used to
study oscillations of the Sun. Five of the six BiSON telescopes are located at
major observatories. The observational sites are, in order of increasing
longitude: Mount Wilson (Hale) Observatory (MWO), California, USA; Las Campanas
Observatory (LCO), Chile; Observatorio del Teide, Iza\~{n}a, Tenerife, Canary
Islands; the South African Astronomical Observatory (SAAO), Sutherland, South
Africa; Carnarvon, Western Australia; and the Paul Wild Observatory, Narrabri,
New South Wales, Australia. The BiSON data may be used to measure atmospheric
extinction coefficients in the band (approximately 700-900 nm),
and presented here are the derived atmospheric extinction coefficients from
each site over the years 1984 to 2016.Comment: 15 pages, 10 figures, 4 tables. Accepted by Astronomical Journal:
2017 July 2
Surfaces roughness effects on the transmission of Gaussian beams by anisotropic parallel plates
Influence of the plate surfaces roughness in precise ellipsometry experiments
is studied. The realistic case of a Gaussian laser beam crossing a uniaxial
platelet is considered. Expression for the transmittance is determined using
the first order perturbation theory. In this frame, it is shown that
interference takes place between the specular transmitted beam and the
scattered field. This effect is due to the angular distribution of the Gaussian
beam and is of first order in the roughness over wavelength ratio. As an
application, a numerical simulation of the effects of quartz roughness surfaces
at normal incidence is provided. The interference term is found to be strongly
connected to the random nature of the surface roughness.Comment: 18 pages, Journal of Physics D: Applied Physics, volume 36, issue 21,
pages 2697 - 270
Mutator Dynamics on a Smooth Evolutionary Landscape
We investigate a model of evolutionary dynamics on a smooth landscape which
features a ``mutator'' allele whose effect is to increase the mutation rate. We
show that the expected proportion of mutators far from equilibrium, when the
fitness is steadily increasing in time, is governed solely by the transition
rates into and out of the mutator state. This results is a much faster rate of
fitness increase than would be the case without the mutator allele. Near the
fitness equilibrium, however, the mutators are severely suppressed, due to the
detrimental effects of a large mutation rate near the fitness maximum. We
discuss the results of a recent experiment on natural selection of E. coli in
the light of our model.Comment: 4 pages, 3 figure
Diurnal Differences in Intracellular Replication Within Splenic Macrophages Correlates With the Outcome of Pneumococcal Infection
Circadian rhythms affect the progression and severity of bacterial infections including those caused by Streptococcus pneumoniae, but the mechanisms responsible for this phenomenon remain largely elusive. Following advances in our understanding of the role of replication of S. pneumoniae within splenic macrophages, we sought to investigate whether events within the spleen correlate with differential outcomes of invasive pneumococcal infection. Utilising murine invasive pneumococcal disease (IPD) models, here we report that infection during the murine active phase (zeitgeber time 15; 15h after start of light cycle, 3h after start of dark cycle) resulted in significantly faster onset of septicaemia compared to rest phase (zeitgeber time 3; 3h after start of light cycle) infection. This correlated with significantly higher pneumococcal burden within the spleen of active phase-infected mice at early time points compared to rest phase-infected mice. Whole-section confocal microscopy analysis of these spleens revealed that the number of pneumococci is significantly higher exclusively within marginal zone metallophilic macrophages (MMMs) known to allow intracellular pneumococcal replication as a prerequisite step to the onset of septicaemia. Pneumococcal clusters within MMMs were more abundant and increased in size over time in active phase-infected mice compared to those in rest phase-infected mice which decreased in size and were present in a lower percentage of MMMs. This phenomenon preceded significantly higher levels of bacteraemia alongside serum IL-6 and TNF-alpha concentrations in active phase-infected mice following re-seeding of pneumococci into the blood. These data greatly advance our fundamental knowledge of pneumococcal infection by linking susceptibility to invasive pneumococcal infection to variation in the propensity of MMMs to allow persistence and replication of phagocytosed bacteria. These findings also outline a somewhat rare scenario whereby the active phase of an organism's circadian cycle plays a seemingly counterproductive role in the control of invasive infection
A database of microRNA expression patterns in Xenopus laevis
MicroRNAs (miRNAs) are short, non-coding RNAs around 22 nucleotides long. They inhibit gene expression either by translational repression or by causing the degradation of the mRNAs they bind to. Many are highly conserved amongst diverse organisms and have restricted spatio-temporal expression patterns during embryonic development where they are thought to be involved in generating accuracy of developmental timing and in supporting cell fate decisions and tissue identity. We determined the expression patterns of 180 miRNAs in Xenopus laevis embryos using LNA oligonucleotides. In addition we carried out small RNA-seq on different stages of early Xenopus development, identified 44 miRNAs belonging to 29 new families and characterized the expression of 5 of these. Our analyses identified miRNA expression in many organs of the developing embryo. In particular a large number were expressed in neural tissue and in the somites. Surprisingly none of the miRNAs we have looked at show expression in the heart. Our results have been made freely available as a resource in both XenMARK and Xenbase
Small RNA Profile in Moso Bamboo Root and Leaf Obtained by High Definition Adapters
Moso bamboo (Phyllostachy heterocycla cv. pubescens L.) is an economically important fast-growing tree. In order to gain better understanding of gene expression regulation in this important species we used next generation sequencing to profile small RNAs in leaf and roots of young seedlings. Since standard kits to produce cDNA of small RNAs are biased for certain small RNAs, we used High Definition adapters that reduce ligation bias. We identified and experimentally validated five new microRNAs and a few other small non-coding RNAs that were not microRNAs. The biological implication of microRNA expression levels and targets of microRNAs are discussed
Corporate political activity in less developed countries:The Volta River Project in Ghana, 1958-66
The article expands existing categorisations of political and economic governance by including literature on less developed countries (LDCs). In four consecutive negotiations between the US multinational Kaisers and the US and Ghana governments in the early 1960s, it is argued that the company reached levels of influence that are at odds with existing explanations. In order to understand corporate political activities in LDCs, analysis needs to go beyond static factors (political risk) and include dynamic factors such as diplomatic relations and 'arenas of power', and consider the role of the investor's home country relative to the host economy
Communications Biophysics
Contains research objectives, summary of research and reports on three research projects.National Institutes of Health (Grant 5 PO1 GM14940-04)National Institutes of Health (Grant 5 TOl GM01555-04)National Aeronautics and Space Administration (Grant NGL 22-009-304
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