Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment

Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND). While 90% of individuals with TSC have some TAND features, only 20% receive treatment, leading to a 70% treatment gap. This study evaluated perception of disease severity, presence of anxiety and depression, as well as the utilization and barriers towards mental health services among adults with TSC. Disease severity had a moderate and low-moderate association with anxiety and depression, respectively. Regardless of past utilization, respondents had a positive outlook towards the use of mental health services with the major barrier being cost

Danse Americaine

https://digitalcommons.library.umaine.edu/mmb-ps/2205/thumbnail.jp

Establishing Retaliation for Purposes of Title VII

An employer is prohibited from retaliating against an employee who engages in a protected activity as defined by Title VII, including opposing discriminatory employment practices or filing charges alleging discrimination by the employer. The Supreme Court took up the issue of what constitutes retaliation for purposes of Title VII in an effort to resolve a split in the circuit courts. This Article examines the different standards used by the circuits and looks at the Sixth Circuit case that was appealed to the Supreme Court, as well as the resolution of that case by the Court. This Article also analyzes the nature of retaliation and the consequences for the law governing employment discrimination

Designing Retail Facilities to Improve Product Exposure

A retail facility should effectively engage consumers during their shopping trips if they want to convert demand into purchases. Unfortunately, the complexity of the retailing environment and lack of scientific tools often results in gut-feel approaches experimented in practice. A key factor to retail design often alluded to, but rarely analyzed, is product exposure to the travelling shopper. We define the extent of the shopper\u27s field of vision in order to determine the actual exposure of products experienced by a traveling shopper. In so doing, we can explore the effect rack orientation has on product exposure. Our main contributions include defining product exposure and an approach to estimate it at any point along the travel path. Our results indicate that certain rack orientations result in product exposures as high as 2.5 times that of the traditional 90° orientation

Performance of a fully close-coupled wave packet method for the H₂+LiF(001) model problem.

The H2+LiF(001) system was used to investigate the performance of the hybrid close‐coupling wave packet (CCWP) method and of a symmetry adapted, fully close‐coupled wave packet (SAWP) method for a molecule–surface problem characterized by fairly high corrugation. In the calculations, a realistic, φ‐dependent model potential was used. The calculations were performed for a collision energy of 0.2 eV, with H2 initially in its j=0 rotational state at normal incidence to the surface. Large increases in the computational efficiencies of both wave packet methods were achieved by taking advantage of the potential coupling matrices associated with both methods becoming sparser with increasing molecule–surface distance. For the present model problem and employing this increased sparseness at longer range, the SAWP method is faster than the CCWP method by a factor of 2. The potential usefulness of the SAWP method for dissociative chemisorption problems is discussed

Sex differences in behavioral decision-making and the modulation of shared neural circuits

Animals prioritize behaviors according to their physiological needs and reproductive goals, selecting a single behavioral strategy from a repertoire of possible responses to any given stimulus. Biological sex influences this decision-making process in significant ways, differentiating the responses animals choose when faced with stimuli ranging from food to conspecifics. We review here recent work in invertebrate models, including C. elegans, Drosophila, and a variety of insects, mollusks and crustaceans, that has begun to offer intriguing insights into the neural mechanisms underlying the sexual modulation of behavioral decision-making. These findings show that an animal's sex can modulate neural function in surprisingly diverse ways, much like internal physiological variables such as hunger or thirst. In the context of homeostatic behaviors such as feeding, an animal's sex and nutritional status may converge on a common physiological mechanism, the functional modulation of shared sensory circuitry, to influence decision-making. Similarly, considerable evidence suggests that decisions on whether to mate or fight with conspecifics are also mediated through sex-specific neuromodulatory control of nominally shared neural circuits. This work offers a new perspective on how sex differences in behavior emerge, in which the regulated function of shared neural circuitry plays a crucial role. Emerging evidence from vertebrates indicates that this paradigm is likely to extend to more complex nervous systems as well. As men and women differ in their susceptibility to a variety of neuropsychiatric disorders affecting shared behaviors, these findings may ultimately have important implications for human health

Six-dimensional quantum dynamics of dissociative chemisorption of (v=0, j=0) H2 on Cu(100).

Theoretical Chemistr