On the use of polymer gels for assessing the total geometrical accuracy in clinical Gamma Knife radiosurgery applications

The nearly tissue equivalent MRI properties and the unique ability of registering 3D dose distributions of polymer gels were exploited to assess the total geometrical accuracy in clinical Gamma Knife applications, taking into account the combined effect of the unit’s mechanical accuracy, dose delivery precision and the geometrical distortions inherent in MR images used for irradiation planning. Comparison between planned and experimental data suggests that the MR-related distortions due to susceptibility effects dominate the total clinical geometrical accuracy which was found within 1 mm. The dosimetric effect of the observed sub-millimetre uncertainties on single shot GK irradiation plans was assessed using the target percentage coverage criterion, and a considerable target dose underestimation was found

On the implementation of a recently proposed dosimetric formalism to a robotic radiosurgery system

The aim of this work is to implement a recently proposed dosimetric formalism for nonstandard fields to the calibration and small field output factor measurement of a robotic stereotactic radiosurgery system

A methodology for assessing and improving the total geometric accuracy in gamma knife radiosurgery

The purpose of the study is to present an end-to-end experimental procedure, based on a polymer gel phantom, capable of assessing the total geometric uncertainty in GK radiosurgery applications, in which MR images are solely used for both target delineation and registration of patient image coordinates to the Leksell space. As a result the study aims to propose a time-efficient method, based on corresponding polymer gel results, which considerably improves the geometric accuracy in GK treatment delivery

Dosimetric accuracy of a deterministic radiation transport based 192Ir brachytherapy treatment planning system: Part III. Comparison to Monte Carlo simulation in voxelized anatomical computational models

To compare TG43-based and Acuros deterministic radiation transport-based calculations of the BrachyVision treatment planning system (TPS) with corresponding Monte Carlo (MC) simulation results in heterogeneous patient geometries, in order to validate Acuros and quantify the accuracy improvement it marks relative to TG43

Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice

An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM ) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has been useful in predicting the functional classes of genes involved and pathways altered during the course of disease. To further understand the contribution of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules – CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM. We find that CD14 plays a predominant role in the induction of ECM and regulation of parasite density; deletion of the CD14 gene not only prevented the onset of disease in a majority of susceptible mice (only 21% of CD14-deficient compared to 80% of wildtype mice developed ECM, p<0.0004) but also had an ameliorating effect on parasitemia (a 2 fold reduction during the cerebral phase). Furthermore, deletion of the galectin-3 gene in susceptible C57BL/6 mice resulted in partial protection from ECM (47% of galectin-3-deficient versus 93% of wildtype mice developed ECM, p<0.0073). Subsequent adherence assays suggest that galectin-3 induced pathogenesis of ECM is not mediated by the recognition and binding of galectin-3 to P. berghei ANKA parasites. A previous study of ECM has demonstrated that brain infiltrating T cells are strongly activated and are CD44+CD62L− differentiated memory T cells [1]. We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4+ and CD8+ T cells accumulated in the brain vasculature is approximately equal

Alien Registration- Moutsatsos, Thomas (Saco, York County)

https://digitalmaine.com/alien_docs/3500/thumbnail.jp

Ansätze der orthodoxen Pastoralpsychologie der Gegenwart: Simeon Krajopoulos und Vasileios Thermos

Diese Arbeit basiert auf dem Werk „Alles zum Guten führen“ von Simeon Krajopoulos, herausgegeben von Ioannis Grintsos in griechischer Sprache und von mir übersetzt. Ergänzend dazu stelle ich die Position von Vasileios Thermos in Diskussion mit Simeon Krajopouolos aus seiner langjährigen Erfahrung als Psychiater, Priester und Beichtvater dar. Ich analysierte ein persönliches, von mir geführtes Interview, einige Reden sowie sein Buch „Heilend: orthodoxe Theologie und Psychotherapie: Ähnlichkeiten und Unterschiede“, welches die Therapie des Menschen aus psychiatrischer, psychologischer Perspektive und aus theologischen Gesichtspunkten betrachtet. Die Arbeit ist in drei große Bereiche aufgeteilt: Erstens in die Methoden der Forschungsfrage und eine einleitende, begriffsklärende Analyse (Kapitel 1 und 2), zweitens in die Darstellung der Thesen von Simeon Krajopoulos (Kapitel 3) und drittens die Diskussion der Gemeinsamkeiten und Unterschiede zwischen Orthodoxer Theologie und Psychotherapie aus der Sicht von V. Thermos (Kapitel 4). Das Fazit und die Schlussfolgerungen (Kapitel 5) zeigen, insbesondere aus der Sicht von V. Thermos, nochmals die Relevanz der Forschung des Krajopoulos für das 21. Jahrhundert und die Notwendigkeit des Zusammenspiels der beiden Disziplinen Theologie und Psychologie auf

Cross-cultural communication in film translation a study of the english subtitled and dubbed versions of "Le déclin de l' Empire américain"

Santamaría, José Miguel; Pajares, Eterio; Olsen, Vickie; Merino, Raquel; Eguíluz, Federico (eds.