The effect of infliximab on oxidative stress after myocardial infarction in rats

Infliximab is a human mouse human chimeric IgG1 antibody that includes human stable regions and variable mouse regions that have inhibitory effects on TNFα, and has recently been used to treat Crohn's disease, urticaria colitis, rheumatoid arthritis, and psoriatic arthritis. This study was conducted to determine the effect of TNFα inhibition on infectious stress and serum lactate levels in infants after isoproterenol induced myocardial infarction in rats. Methods and Results: For induction of myocardial infarction (MI), isoproterenol (100 mg/kg) was injected subcutaneously in a 24-hour saline solution in normal saline for 24 days. Animals after 24, 48, 72 and 96 hours after the second dose of isoproterenol was surgically treated. After infusion of inflections, 24, 48, 72 and 96 hours of surgery were performed. Anesthesia for animal surgery with ketamine and xylazine (3 to 2. Blood samples were collected from the hepatic vein and serum was used after the isolation to measure biochemical factors. At the end of the test, the heart was quickly separated and washed with normal cold saline and water was taken and weighed. Induced infarction with isoproterenol 100 mg/kg changes the pattern and parameters of electrocardiography and hemodynamics, and also causes hypertrophy, necrosis, edema and severe cardiac inflammation. Injection of infliximab at a dose of 7 mg/kg in the mentioned intervals did not have an effect on induced hypertrophy due isoproterenol. Isoproterenol increases lipid peroxidation, lactate dehydrogenase, total serum antioxidant and heart tissue, and serum lactate, which seems to be a significant reduction in the levels of MDA, TAC, LDH, and LDH, especially in the early hours of myocardial infarction. Lactate reduces serum levels. But in some cases, with the passage of time does not apply photo effects. Conclusion: The results of this study showed that infliximab, at 24-48 hours after MI, has a protective effect on cardiac myocardial infarction, and in the long term may exacerbate oxidative activity

UV-shielding properties of a cost-effective hybrid PMMA-based thin film coatings using TiO2 and ZnO nanoparticles: a comprehensive evaluation

Abstract This study aimed to assess the UV-shielding features of the PMMA-based thin film coatings with the addition of TiO2 and ZnO nanoparticles as nanofillers considering different contents. Furthermore, the effect of TiO2/ZnO nanohybrids at different ratios and concentrations was examined. The XRD, FTIR, SEM, and EDX analyses characterized the prepared films' functional groups, structure, and morphology. Meanwhile, the coatings' optical properties and UV-protecting capability were investigated by ultraviolet–visible (UV–Vis) spectroscopy. The UV–Vis spectroscopic study revealed that as the concentration of nanoparticles increased in the hybrid-coated PMMA, the absorption in the UVA region increased. Overall, it can be concluded that the optimal coatings for PMMA were 0.1 wt% TiO2, 0.1 wt% ZnO, and 0.025:0.025 wt% TiO2: ZnO nanohybrid. Considering the acquired FT-IR of PMMA with different content of nanoparticles before and after exposure to the UV irradiation, for some films, it was confirmed that the polymer-based thin films degraded after 720 h, with either decreasing or increasing intensity of the degraded polymer, peak shifting, and band broadening. Notably, the FTIR results were in good agreement with UV–Vis outcomes. In addition, XRD diffraction peaks demonstrated that the pure PMMA matrix and PMMA coating films did not show any characteristic peaks indicating the presence of nanoparticles. All diffraction patterns were similar with and without any nanoparticles. Therefore, it depicted the amorphous nature of polymer thin film