Fingering convection and cloudless models for cool brown dwarf atmospheres

This work aims to improve the current understanding of the atmospheres of brown dwarfs, especially cold ones with spectral type T and Y, whose modeling is a current challenge. Silicate and iron clouds are believed to disappear at the photosphere at the L/T transition, but cloudless models fail to reproduce correctly the spectra of T dwarfs, advocating for the addition of more physics, e.g. other types of clouds or internal energy transport mechanisms. We use a one-dimensional (1D) radiative/convective equilibrium code ATMO to investigate this issue. This code includes both equilibrium and out-of-equilibrium chemistry and solves consistently the PT structure. Included opacity sources are H2-H2, H2-He, H2O, CO, CO2, CH4, NH3, K, Na, and TiO, VO if they are present in the atmosphere. We show that the spectra of Y dwarfs can be accurately reproduced with a cloudless model if vertical mixing and NH3 quenching are taken into account. T dwarf spectra still have some reddening in e.g. J - H compared to cloudless models. This reddening can be reproduced by slightly reducing the temperature gradient in the atmosphere. We propose that this reduction of the stabilizing temperature gradient in these layers, leading to cooler structures, is due to the onset of fingering convection, triggered by the destabilizing impact of condensation of very thin dust.Comment: Accepted in ApJ

The acceleration of superrotation in simulated hot Jupiter atmospheres

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordContext. Atmospheric superrotating flows at the equator are a nearly ubiquitous result when conducting simulations of hot Jupiters. One theory explaining how this zonally-coherent flow reaches equilibrium has already been developed in the literature. This understanding, however, relies on the existence of either an initial superrotating flow or a sheared flow, coupled with a slow evolution that permits a linear steady state to be reached. Aims. A consistent physical understanding of superrotation is needed for arbitrary drag and radiative timescales, along with the relevance of taking linear steady states into account, needs to be assessed. Methods. We obtained an analytical expression for the structure, frequency, and decay rate of propagating waves in hot Jupiter atmospheres around a state at rest in the 2D shallow-water β–plane limit. We solved this expression numerically and confirmed the robustness of our results with a 3D linear wave algorithm. We then compared it with 3D simulations of hot Jupiter atmospheres and studied the nonlinear momentum fluxes. Results. We show that under strong day-night heating, the dynamics do not transit through a linear steady state when starting from an initial atmosphere in solid body rotation. We further demonstrate that non–linear effects favor the initial spin-up of superrotation and that acceleration due to the vertical component of the eddy–momentum flux is critical to the initial development of superrotation . Conclusions. We describe the initial phases of the acceleration of superrotation, including the consideration of differing radiative and drag timescales, and we conclude that eddy-momentum-driven superrotating equatorial jets are robust, physical phenomena in simulations of hot Jupiter atmospheres.Leverhulme TrustScience and Technology Facilities Counci

Beam Dynamics and First Operation of the Sub-Harmonic Bunching System in the CTF3 Injector

The CLIC Test Facility 3 (CTF3), built at CERN by an international collaboration, aims at demonstrating the feasibility of the CLIC scheme by 2010. The CTF3 drive beam generation scheme relies on the use of a fast phase switch of a sub-harmonic bunching system in order to phase-code the bunches. The amount of charge in unwanted satellite bunches is an important quantity, which must be minimized. Beam dynamic simulations have been used to study the problem, showing the limitation of the present CTF3 design and the gain of potential upgrades. In this paper the results are discussed and compared with beam measurements taken during the first operation of the system

Cutavirus in cutaneous malignant melanoma

A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains to be investigated

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their diverse molecular targets, display protease-resistance, and are highly stable and poorly immunogenic. The wealth of structural knowledge makes them good candidates for protein engineering of new functionality. Our goal is to enhance the efficacy of these mini-proteins by modifying their pharmacological properties in order to extend their use in imaging, diagnostics and therapeutic applications. Using the interaction of three-finger fold toxins with muscarinic and adrenergic receptors as a model, chimeric toxins have been engineered by substituting loops on toxin MT7 by those from toxin MT1. The pharmacological impact of these grafts was examined using binding experiments on muscarinic receptors M1 and M4 and on the α1A-adrenoceptor. Some of the designed chimeric proteins have impressive gain of function on certain receptor subtypes achieving an original selectivity profile with high affinity for muscarinic receptor M1 and α1A-adrenoceptor. Structure-function analysis supported by crystallographic data for MT1 and two chimeras permits a molecular based interpretation of these gains and details the merits of this protein engineering technique. The results obtained shed light on how loop permutation can be used to design new three-finger proteins with original pharmacological profiles

Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion

In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited. Nonetheless, TEs have been initially proposed as positive control elements acting in synergy with the host. Nowadays, it is well known that TE movement into host genome comprises an important evolutionary mechanism capable of increasing the adaptive fitness. As insights into TE functioning are increasing day to day, the manipulation of transposition has raised an interesting possibility of setting the host functions, although the lack of appropriate genome engineering tools has unpaved it. Fortunately, the emergence of genome editing technologies based on programmable nucleases, and especially the arrival of a multipurpose RNA-guided Cas9 endonuclease system, has made it possible to reconsider this challenge. For such purpose, a particular type of transposons referred to as miniature inverted-repeat transposable elements (MITEs) has shown a series of interesting characteristics for designing functional drivers. Here, recent insights into MITE elements and versatile RNA-guided CRISPR/Cas9 genome engineering system are given to understand how to deploy the potential of TEs for control of the host transcriptional activity.Fil: Vaschetto, Luis Maria Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Diversidad Animal I; Argentin

Complementarity and Discriminatory Power of Genotype and Otolith Shape in Describing the Fine-Scale Population Structure of an Exploited Fish, the Common Sole of the Eastern English Channel

Marine organisms show population structure at a relatively fine spatial scale, even in open habitats. The tools commonly used to assess subtle patterns of connectivity have diverse levels of resolution and can complement each other to inform on population structure. We assessed and compared the discriminatory power of genetic markers and otolith shape to reveal the population structure on evolutionary and ecological time scales of the common sole (Solea solea), living in the Eastern English Channel (EEC) stock off France and the UK. First, we genotyped fish with Single Nucleotide Polymorphisms to assess population structure at an evolutionary scale. Then, we tested for spatial segregation of the subunits using otolith shape as an integrative tracer of life history. Finally, a supervised machine learning framework was applied to genotypes and otolith phenotypes to probabilistically assign adults to subunits and assess the discriminatory power of each approach. Low but significant genetic differentiation was found among subunits. Moreover, otolith shape appeared to vary spatially, suggesting spatial population structure at fine spatial scale. However, results of the supervised discriminant analyses failed to discriminate among subunits, especially for otolith shape. We suggest that the degree of population segregation may not be strong enough to allow for robust fish assignments. Finally, this study revealed a weak yet existing metapopulation structure of common sole at the fine spatial scale of the EEC based on genotypes and otolith shape, with one subunit being more isolated. Our study argues for the use of complementary tracers to investigate marine population structure