PERFORMA AKUSTIK PADA RUANG MUSIK DI SEKOLAH LUAR BIASA NEGERI MARAWOLA KABUPATEN SIGI

Ruang musik dengan menggunakan bahan isolasi bunyi dari glasswool yang dipadukan dengan beberapa bahan bangunan, seperti tripleks, hardboard dan dinding bata, serta desain tata letak ruang dan bukaan yang spesifik sesuai dengan aturan performa akustik pada umumnya, dimana akan dibahas eksplorasi desain akustik dengan pendekatan analisa pengaruh level/tingkatan suara.Hasil penelitian menunjukkan bahwa kajian performa level suara dan performa akuistik menunjukkan hasil yang signifikan yaitu mampu menghilangkan dengung dalam ruang sehingga menghasilkan suara musik yang baik dalam ruang dan mampu menahan rambatan bunyi poda lingkungan sekitarnya sehingga keberadaan ruang musik di Sekolah Luar Biasa Marawola tersebut tidak menggangu aktifitas belajar-mengajar pada ruang sekitarny

Fluid challenges in intensive care: the FENICE study A global inception cohort study

Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC.2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response.The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account

Optimization of castor seed oil extraction process using response surface methodology

This work focuses on the study of the oil extraction yield from castor seed using three different seed conditions: whole, minced and bare endosperm. Taguchi design was used to determine the contribution of the following parameters: seed condition, seed load in the extractor, temperature, and pressure. It was proved that it is necessary to introduce the whole seed and that the presence of the pericarp increases the extraction yield. The contribution of the control factors has an extraction yield limit. After determining which factors contributed to the process, these were left at their optimum levels aiming to reduce the control factors to only two. The complete analysis was done using a surface response methodology giving the best parameter for temperature and pressure that allows a better yielding mechanical extraction. The oil extraction yield can be kept up to 35% of the seed

Optimization of castor seed oil extraction process using response surface methodology

This work focuses on the study of the oil extraction yield from castor seed using three different seed conditions: whole, minced and bare endosperm. Taguchi design was used to determine the contribution of the following parameters: seed condition, seed load in the extractor, temperature, and pressure. It was proved that it is necessary to introduce the whole seed and that the presence of the pericarp increases the extraction yield. The contribution of the control factors has an extraction yield limit. After determining which factors contributed to the process, these were left at their optimum levels aiming to reduce the control factors to only two. The complete analysis was done using a surface response methodology giving the best parameter for temperature and pressure that allows a better yielding mechanical extraction. The oil extraction yield can be kept up to 35% of the seed.Este trabajo se centra en el estudio de la extracción y la producción de aceite de semillas de ricino usando tres diferentes estados de semillas: entera, partida y sin testa. Se utilizó un diseño Taguchi para determinar la contribución de los siguientes parámetros: estado de las semillas, cantidad de semilla en el extractor, temperatura y presión. Se demostró que es necesario introducir la semilla entera para aumentar el rendimiento de la extracción. La contribución de los factores de control tiene un límite de extracción en la variable respuesta (rendimiento). Después de determinar cuáles factores contribuían altamente al proceso de extracción y cuáles no, se procedió a dejarlos en los niveles de mayor contribución con la finalidad de reducir el número de factores de control a dos. Posteriormente se utilizó la metodología de superficie de respuesta para la optimización del proceso, dando como resultado los niveles óptimos para los factores de control temperatura y presión. De acuerdo con las pruebas, el rendimiento de la extracción del aceite se puede mantener en un 35% de la semilla

Optimization of castor seed oil extraction process using response surface methodology

This work focuses on the study of the oil extraction yield from castor seed using three different seed conditions: whole, minced and bare endosperm. Taguchi design was used to determine the contribution of the following parameters: seed condition, seed load in the extractor, temperature, and pressure. It was proved that it is necessary to introduce the whole seed and that the presence ofthe pericarp increases the extraction yield. The contribution of the control factors has an extraction yield limit. After determining which factors contributed to the process, these were left at their optimum levels aiming to reduce the control factors to only two. The complete analysis was done using a surface response methodology giving the best parameter for temperature and pressure that allows a better yielding mechanical extraction. The oil extraction yield can be kept up to 35% of the seed

Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.

Two-pore channels (TPCs or TPCNs) are novel voltage-gated ion channels that have been postulated to act as Ca2+ and/or Na+ channels expressed exclusively in acidic organelles such as endosomes and lysosomes. TPCNs participate in the regulation of diverse biological processes and recently have been proposed to be involved in the pathophysiology of metabolic disorders such as obesity, fatty liver disease and type 2 diabetes mellitus. Due to the importance of these pathologies in the development of cardiovascular diseases, we aimed to study the possible role of two-pore channel 1 (TPCN1) in the regulation of cardiac metabolism. To explore the cardiac function of TPCN1, we developed proteomic approaches as 2-DE-MALDI-MS and LC-MALDI-MS in the cardiac left ventricle of TPCN1 KO and WT mice, and found alterations in several proteins implicated in glucose and fatty acid metabolism in TPCN1 KO vs. WT mice. The results confirmed the altered expression of HFABP, a key fatty acid transport protein, and of enolase and PGK1, the key enzymes in the glycolytic process. Finally, in vitro experiments performed in neonatal rat cardiomyocytes, in which TPCN1 was silenced using siRNAs, confirmed that the downregulation of TPCN1 gene expression increased 2-deoxy-D-[3H]-glucose uptake and GLUT4 mobilization into cell peripherals in cardiac cells. Our results are the first to suggest a potential role for TPCNs in cardiac metabolism regulation