Kulturdiskurs und demokratische Partizipation

Ausgehend von der Fragestellung nach einer vermehrten „ethnischen Lesart“ politischer Problemstellungen setzt sich die Arbeit im ersten Teil mit Grundzügen der anthropologischen und demokratischen Theoriebildung auseinander. Ziel ist es hierbei eine interdisziplinäre Grundlage zu erarbeiten, die es ermöglichen soll, den prozesshaften Wandel, der einem solchen Perspektivenwechsel einhergeht, analysierbar zu machen. Die Ergebnisse dieser Auseinandersetzung werden am Ende des Theorieteils in eine interdisziplinäre Grundlage zusammengeführt In Teil II kommt diese analytische Grundlage zunächst in zwei Versuchen zur Anwendung. Das empirische Material dieser Versuche entstammt dabei einer Forschungsarbeit von Sabine Mannitz, die die Auswirkungen dominanter nationaler Kulturdiskurse auf das diskursive Handeln von Schülern in vier europäischen Ländern untersucht hat. Zwei kurze Diskursfragmente, die sich aufgrund ihrer Verschränkung von kulturspezifischen und demokratiepolitischen Ebenen für eine versuchsweise Anwendung der interdisziplinären Grundlage eignen, werden hier untersucht. Im zweiten Kapitel wird dann versucht, entlang eines Briefwechsels zwischen einem anonymen „Migrationshintergrundverweigerer“ und einer Redakteurin, der dem Online-Format der Tageszeitung „Der Standard“ entnommen wurde, diese analytische Grundlage erstmals eigenständig zur Anwendung kommen zu lassen. Schließlich wird im letzten Teil der Arbeit der Begriff des „communautarisme“ auseinandergesetzt, wobei hier zunächst das bereits erwähnte Interview mit einem Pariser Journalisten untersucht wird, bevor ein Abschnitt aus einem TV-Duell der beiden Spitzenkandidaten des französischen Präsidentschaftswahlkampf 2012, François Hollande und Nicolas Sarkozy, analysiert wird. Thema dieser Auseinandersetzung ist dabei zunächst die Einführung des kommunalen Wahlrechts für Nicht-EU-Bürger in Frankreich, wobei diese Thematik zusehends in eine Debatte über den „communautarisme“ übergeht

Evaluation of polarimetric ice microphysical retrievals with OLYMPEX campaign data

We present an evaluation of current retrieval techniques in the ice phase applied to polarimetric radar measurements with collocated in situ observations of aircraft conducted over the Olympic Mountains, Washington State, during winter 2015. Radar estimates of ice properties agreed most with aircraft observations in regions with pronounced radar signatures, but uncertainties were identified that indicate issues of some retrievals, particularly in warmer temperature regimes

Luminescence from two-dimensional electron gases in InAlN/GaN heterostructures with different In content

The luminescence properties of InxAl1−xN/GaN heterostructures are investigated systematically as a function of the In content (x = 0.067 − 0.208). The recombination between electrons confined in the two-dimensional electron gas and free holes in the GaN template is identified and analyzed. We find a systematic shift of the recombination with increasing In content from about 80 meV to only few meV below the GaN exciton emission. These results are compared with model calculations and can be attributed to the changing band profile and originating from the polarization gradient between InAlN and GaN

Harding University Course Catalog 1988-1989

Catalog of Harding University 1988-1989https://scholarworks.harding.edu/catalogs/1050/thumbnail.jp

Molecular profiling of soft-tissue sarcomas with FoundationOne® Heme identifies potential targets for sarcoma therapy: a single-centre experience

Background: Molecular diagnosis has become an established tool in the characterisation of adult soft-tissue sarcomas (STS). FoundationOne ® Heme analyses somatic gene alterations in sarcomas via DNA and RNA-hotspot sequencing of tumour-associated genes. Methods: We evaluated FoundationOne ® Heme testing in 81 localised STS including 35 translocation-associated and 46 complex-karyotyped cases from a single institution. Results: Although FoundationOne ® Heme achieved broad patient coverage and identified at least five genetic alterations in each sample, the sensitivity for fusion detection was rather low, at 42.4%. Nevertheless, potential targets for STS treatment were detected using the FoundationOne ® Heme assay: complex-karyotyped sarcomas frequently displayed copy-number alterations of common tumour-suppressor genes, particularly deletions in TP53 , NF1 , ATRX , and CDKN2A . A subset of myxofibrosarcomas (MFS) was amplified for HGF ( n  = 3) and MET ( n  = 1). PIK3CA was mutated in 7/15 cases of myxoid liposarcoma (MLS; 46.7%). Epigenetic regulators (e.g. MLL2 and MLL3 ) were frequently mutated. Conclusions: In summary, FoundationOne ® Heme detected a broad range of genetic alterations and potential therapeutic targets in STS (e.g. HGF/MET in a subset of MFS, or PIK3CA in MLS). The assay’s sensitivity for fusion detection was low in our sample and needs to be re-evaluated in a larger cohort

Benefit of second-line therapy for advanced esophageal squamous cell carcinoma: a tri-center propensity score analysis

BACKGROUND: The level of evidence for palliative second-line therapy in advanced esophageal squamous cell carcinoma (aESCC) is limited. This is the first study that reports efficacy data comparing second-line therapy + active symptom control (ASC) versus ASC alone in aESCC. METHODS: We conducted a tri-center retrospective cohort study (n = 166) including patients with aESCC who had experienced disease progression on palliative first-line therapy. A propensity score model using inverse probability of treatment weighting (IPTW) was implemented for comparative efficacy analysis of overall survival (OS) in patients with second-line + ASC (n = 92, 55%) versus ASC alone (n = 74, 45%). RESULTS: The most frequent second-line regimens used were docetaxel (36%) and paclitaxel (18%). In unadjusted primary endpoint analysis, second-line + ASC was associated with significantly longer OS compared with ASC alone [hazard ratio (HR) = 0.49, 95% confidence interval (CI): 0.35–0.69, p < 0.0001]. However, patients in the second-line + ASC group were characterized by more favorable baseline features including a better Eastern Cooperative Oncology Group (ECOG) performance status, a longer first-line treatment duration and lower C-reactive protein levels. After rigorous adjusting for baseline confounders by re-weighting the data with the IPTW the favorable association between second-line and longer OS weakened but prevailed. The median OS was 6.1 months in the second-line + ASC group and 3.2 months in the ASC group, respectively (IPTW-adjusted HR = 0.40, 95% CI: 0.24–0.69, p = 0.001). Importantly, the benefit of second-line was consistent across several clinical subgroups, including patients with ECOG performance status ⩾1 and age ⩾65 years. The most common grade 3 or 4 adverse events associated with palliative second-line therapy were hematological toxicities. CONCLUSION: This real-world study supports the concept that systemic second-line therapy prolongs survival in patients with aESCC

Search for supersymmetry with a dominant R-parity violating LQDbar couplings in e+e- collisions at centre-of-mass energies of 130GeV to 172 GeV

A search for pair-production of supersymmetric particles under the assumption that R-parity is violated via a dominant LQDbar coupling has been performed using the data collected by ALEPH at centre-of-mass energies of 130-172 GeV. The observed candidate events in the data are in agreement with the Standard Model expectation. This result is translated into lower limits on the masses of charginos, neutralinos, sleptons, sneutrinos and squarks. For instance, for m_0=500 GeV/c^2 and tan(beta)=sqrt(2) charginos with masses smaller than 81 GeV/c^2 and neutralinos with masses smaller than 29 GeV/c^2 are excluded at the 95% confidence level for any generation structure of the LQDbar coupling.Comment: 32 pages, 30 figure