PKM OPTIMALISASI PEMBUATAN PAKAN IKAN SECARA MEKANIS DI KAMPUNG HIUNG KECAMATAN MANGANITU KABUPATEN KEPULAUAN SANGIHE

Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah memberikan pengetahuan dan ketrampilan secara luas kepada masyarakat pembudidaya ikan yang ada di Kampung Hiung tentang pembuatan pakan ikan secara mekanis. Metode dalam pelaksanaan kegiatan pengabdian kepada masyarakat ini meliputi survey, persiapan, ceramah, dan pelatihan. Kegiatan ceramah dan pelatihan dalam pengabdian kepada masyarakat direspon dengan baik oleh masyarakat. Masyarakat pun mengajukan beberapa pertanyaan dalam sesi ceramah dan turut berpartisipasi dalam kegiatan pengoperasian mesin penepung maupun pembuatan pakan ikan. Kesimpulan yang dapat ditarik lewat kegiatan pengabdian kepada masyarakat ini adalah pengetahuan dan ketrampilan membuat pakan ikan penting untuk diberikan kepada masyarakat pembudidaya ika

Peningkatan Pertumbuhan dan Sintasan Hidup Ikan Bawal (Colossoma macropumum) dengan Penambahan Ragi Roti dalam Pakan

The conducted of this study was to investigate the effect of yeast on growth and survival rate of freshwater pomfret fish. This research used complete randomized design with five treatments, each with 3 replications. The treatments was given by treament A (0 gr yeast/ kg feed), B ( 5 gr yeast/ kg feed), C (10 gr yeast/kg feed), D (15 gr yeast/ kg feed), E (20 gr yeast/ kg feed). Frequency of feeding was 2 times a day 5%bb. This research showed that the addition of yeast significally influenced growth and survival rate of pomfret fish. The higest yeast dossage in feed causing highest growth of pomfret fish.Tujuan penelitian ini untuk mengetahui pengaruh pemberian ragi roti terhadap pertumbuhan ikan bawal (Colossoma macropomum). Ikan bawal yang digunakan berukuran 5-8 cm dengan berat awal 11,35 gr. Rancangan penelitian berupa rancangan acak lengkap dengan empat perlakuan yaitu, A (0 gr ragi roti/ kg pakan), perlakuan B (5 gr ragi roti/kg pakan), perlakuan C (10 gr ragi roti/kg pakan), perlakuan D (15 gr ragi roti/kg pakan). Perlakuan E (20 gr ragi roti/kg pakan). Frekuensi pemberian pakan dua kali sehari dengan jumlah pakan berdasarkan 5%bb. Hasil penelitian menunjukkan bahwa penambahan ragi roti berpengaruh nyata terhadap pertumbuhan dan sintasan hidup ikan bawal. Semakin tinggi dosis ragi roti dalam pakan, semakin tinggi pertumbuhan ikan bawal

PKM MASYARAKAT PESISIR DENGAN PENCEGAHAN DIABETES MELITUS DAN HIPERURISEMIA DI KAMPUNG BULO KECAMATAN TABUKAN SELATAN KABUPATEN KEPULAUAN SANGIHE PROVINSI SULAWESI UTARA

Diabetes Melitus (DM) adalah suatu kumpulan gejala yang timbul pada seseorang yang disebabkan oleh karena adanya peningkatan kadar gula darah (glukosa) darah akibat kekurangan insulin baik absolut maupun relative. Sedangkan hiperurisemia (asam urat berlebih) adalah kosentrasi asam urat yang larut dalam darah (> 6.8 mg/dl) akibat over produksi asam urat atau ekskresi (pengeluaran) yang berkurang serta kelainan kosentrasi zat dalam serum yang cukup sering ditemukan. Kampung Bulo Kecamatan Tabukan Selatan merupakan salah satu kampung di Kabupaten Kepulauan Sangihe. Kampung ini terletak + 5 mil dari Ibukota Kecamatan dan merupakan sebuah pulau yang harus dilalui dengan perahu motor kira-kira 15-20 menit Karakteristik masyarakat diKampung Bulo Kecamatan Tabukan Selatan sangat berpotensi menimbulkan angka kasus DM dan hiperurisemia menjadi tinggi karena masyarakat Kampung Bulo mengalami perubahan gaya hidup yakni sering mengkonsumsi makanan tinggi purin dan memiliki kebiasaan minum alcohol serta kurangnya pengawasan terhadap peningkatan kadar gula darah dan kadar asam urat berlebih dalam darah. Metode yang digunakan untuk menyekesaikan permasalahan mitra adalah dengan penyuluhan kesehatan dan pemeriksaan kesehatan. Masyarakat yang hadir saat penyuluhan kesehatan berjumlah 48 orang dan yang melakukan pemeriksaan kesehatan berjumlah 41 orang

Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta- Analysis

Background-—Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results-—We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level metaanalysis was performed using random-effects models; individual participant meta-analyses used a 2-stage analytic strategy, examining effects in prespecified subgroups. 31trials (2751 participants) were included; 29 trials (2641participants) contributed data to trial-level meta-analysis, and24trials (2051 participants) contributed to individual-participant analyses. VitaminD3daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to12 months. Trial-level meta-analysis showed no significant effect of supplementation on macrovascularmeasures(flow-mediateddilatation,0.37%[95%confidenceinterval, 0.23to0.97]; carotid-femoralpulsewavevelocity, 0.00 m/s [95% confidence interval, 0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial-level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions-—Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis

Social Value of Marine and Coastal Protected Areas in England and Wales.

The U.K. government is committed to establishing a coherent network of marine protected areas by 2012 and the recentMarine and Coastal Access Act, 2009 will designate marine conservation zones and provide wider access rights to the coast. To fulfill these goals, this article argues the need for a clearer, shared understanding of the social value of protected areas in creating new designations and managing existing ones. Although marine and coastal environments attract many people and are vitally important in terms of realized and potential social value, the majority of the public in the United Kingdom lacks understanding and awareness regarding them. Combined with this, the social value of marine and coastal protected areas (MCPAs) have been largely ignored relative to conservation and economics, with the latter invariably taking precedence in environmental policymaking. Social value reflects the complex, individual responses that people experience in a given place. Many reasons determine why one area is valued above another, and this research investigates the social value of MCPAs from a practitioner’s perspective through a series of interviews. Understanding why we “socially” value MCPAs will ultimately equip managers with an informed understanding of these spaces, influence management decisions, and, potentially, policymaking. This article defines social value in the context of MCPAs in England and Wales from a practitioner perspective, explores key concepts, and suggests possible improvements in decision-making

Modeling Joint Exposures and Health Outcomes for Cumulative Risk Assessment: The Case of Radon and Smoking

Community-based cumulative risk assessment requires characterization of exposures to multiple chemical and non-chemical stressors, with consideration of how the non-chemical stressors may influence risks from chemical stressors. Residential radon provides an interesting case example, given its large attributable risk, effect modification due to smoking, and significant variability in radon concentrations and smoking patterns. In spite of this fact, no study to date has estimated geographic and sociodemographic patterns of both radon and smoking in a manner that would allow for inclusion of radon in community-based cumulative risk assessment. In this study, we apply multi-level regression models to explain variability in radon based on housing characteristics and geological variables, and construct a regression model predicting housing characteristics using U.S. Census data. Multi-level regression models of smoking based on predictors common to the housing model allow us to link the exposures. We estimate county-average lifetime lung cancer risks from radon ranging from 0.15 to 1.8 in 100, with high-risk clusters in areas and for subpopulations with high predicted radon and smoking rates. Our findings demonstrate the viability of screening-level assessment to characterize patterns of lung cancer risk from radon, with an approach that can be generalized to multiple chemical and non-chemical stressors

F- and G-Actin Concentrations in Lamellipodia of Moving Cells

Cells protrude by polymerizing monomeric (G) into polymeric (F) actin at the tip of the lamellipodium. Actin filaments are depolymerized towards the rear of the lamellipodium in a treadmilling process, thereby supplementing a G-actin pool for a new round of polymerization. In this scenario the concentrations of F- and G-actin are principal parameters, but have hitherto not been directly determined. By comparing fluorescence intensities of bleached and unbleached regions of lamellipodia in B16-F1 mouse melanoma cells expressing EGFP-actin, before and after extraction with Triton X-100, we show that the ratio of F- to G-actin is 3.2+/−0.9. Using electron microscopy to determine the F-actin content, this ratio translates into F- and G-actin concentrations in lamellipodia of approximately 500 µM and 150 µM, respectively. The excess of G-actin, at several orders of magnitude above the critical concentrations at filament ends indicates that the polymerization rate is not limited by diffusion and is tightly controlled by polymerization/depolymerization modulators

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Measurement of the Associated γ+μ±\gamma + \mu^\pm Production Cross Section in ppˉp \bar p Collisions at s=1.8\sqrt{s} = 1.8 TeV

We present the first measurement of associated direct photon + muon production in hadronic collisions, from a sample of 1.8 TeV $p \bar p$ collisions recorded with the Collider Detector at Fermilab. Quantum chromodynamics (QCD) predicts that these events are primarily from the Compton scattering process $cg \to c\gamma$, with the final state charm quark producing a muon. Hence this measurement is sensitive to the charm quark content of the proton. The measured cross section of $29\pm 9 pb^{-1}$ is compared to a leading-order QCD parton shower model as well as a next-to-leading-order QCD calculation.Comment: 12 pages, 4 figures Added more detailed description of muon background estimat