471 research outputs found

    History shows that Greece is able to implement meaningful reform

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    But it also shows that external pressure is crucial in unlocking the reform potential, writes Matthias Mory

    Optimization of shielding and targeting domains within sequence-defined, cationic carriers for pDNA delivery

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    Globalization, 1870-1914

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    This paper surveys the causes and consequences of late 19th century globalization, as well as the anti-globalization backlash of that period.

    Nucleus accumbens volume is related to obesity measures in an age‐dependent fashion

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    Motivation theories of obesity suggest that one of the brain mechanisms underlying pathological eating and weight gain is the dysregulation of dopaminergic circuits. While these dysregulations occur likely at the microscopic level, studies on gray matter volume reported macroscopic differences associated with obesity. One region suggested to play a key role in the pathophysiology of obesity is the nucleus accumbens (NAcc). We performed a meta‐analysis of findings regarding NAcc volume and overweight/obesity. We additionally examined whether gray matter volume in the NAcc and other mesolimbic areas depends on the longitudinal trajectory of obesity, using the UK Biobank dataset. To this end, we analysed the data using a latent growth model, which identifies whether certain variables of interest (e.g. NAcc volume) is related to another variable's (BMI) initial values or longitudinal trajectories. Our meta‐analysis showed that, overall, NAcc volume is positively related to BMI. However, further analyses revealed that the relationship between NAcc volume and BMI is dependent on age. For younger individuals such relationship is positive, while for older adults it is negative. This was corroborated by our analysis in the UK Biobank dataset, which includes older adults, where we found that higher BMI was associated with lower NAcc and thalamus volume. Overall, our study suggests that increased NAcc volume in young age might be a vulnerability factor for obesity, while in the older age decreased NAcc volume with increased BMI might be an effect of prolonged influences of neuroinflammation on the brain

    Europe and Globalization, 1870-1914

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    This paper surveys the causes and consequences of late 19th century globalization, as well as the anti-globalization backlash of that period

    Monitoring of Temperatures in Turning with Intelligent Tools

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    Import 05/08/2014Tato bakalářská práce se zabývá měřením teplot při soustružení s inteligentním nástrojem. Inteligentní nástroj je vyměnitelná břitová destička z řezné keramiky, na které je nanesena odporová vrstva. Dále jsou rozebrány metody měření teploty řezání při soustružení a rozbory keramických nástrojových materiálů. Hlavní část této bakalářské práce se zabývá rozborem a následným vyhodnocením naměřených dat získaných při experimentu.Thisbachelor thesis dealsMeasurementoftemperatures in turningwithintelligenttools. TheIntelligenttooliscuttinginsertsofcuttingceramics, on whichisappliedtheresistivelayer. Are alsodiscussedmethodsofmeasuringcuttingtemperaturewhenturning, and analysisofceramictoolmaterials. Themain part ofthis thesis dealswiththeanalysis and subsequentevaluationofthemeasured data obtained in the experiment.346 - Katedra obrábění a montáževýborn
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