1,301 research outputs found
A Review of 105 Consecutive Uniport Endoscopic Plantar Fascial Release Procedures for the Treatment of Chronic Plantar Fasciitis
Plantar fasciitis is a common cause of heel pain in the U.S. Army soldier, resulting in a significant loss of man hours. Given the heavy operations tempo of the U.S. military, successful treatment options need to be considered and used as quickly as possible. Plantar fasciitis can be successfully treated in up to 90% of patients using conservative measures. Operative intervention might need to be considered for those in whom conservative measures have failed. The present report is a review of 105 consecutive uniport endoscopic plantar fascial release procedures performed by the principal investigator during a 9-year period. The following data were collected and analyzed: gender, age, weight, height, body mass index, medical treatment facility, procedure laterality, preoperative pain levels, postoperative pain levels at 3 months, first ambulatory day in the controlled ankle motion boot, return to activity as tolerated, and complications. Three major points were of interest: evidence of improvement in chronic plantar fasciitis when treated with uniport endoscopic procedures; the patient attributes associated with self-reported pain levels 90 days postoperatively; and the patient attributes associated with the average time until patients were able to return to activities as tolerated in a controlled ankle motion boot. It was noted that 44.5% of those with a body mass index of 29.80 kg/m2 or greater reported a postoperative pain level of 0; and 96.3% of those with a body mass index of 25.53 kg/m2 or less reported postoperative pain levels of 0. The analyzed data were used to characterize the clinical outcomes of the procedure, identify changes in outcome with surgeon experience, and identify whether certain patient subgroups have better outcomes, allowing surgeons to identify which patient might be the best candidates for an endoscopic release procedure
A Review of 105 Consecutive Uniport Endoscopic Plantar Fascial Release Procedures for the Treatment of Chronic Plantar Fasciitis
Plantar fasciitis is a common cause of heel pain in the U.S. Army soldier, resulting in a significant loss of man hours. Given the heavy operations tempo of the U.S. military, successful treatment options need to be considered and used as quickly as possible. Plantar fasciitis can be successfully treated in up to 90% of patients using conservative measures. Operative intervention might need to be considered for those in whom conservative measures have failed. The present report is a review of 105 consecutive uniport endoscopic plantar fascial release procedures performed by the principal investigator during a 9-year period. The following data were collected and analyzed: gender, age, weight, height, body mass index, medical treatment facility, procedure laterality, preoperative pain levels, postoperative pain levels at 3 months, first ambulatory day in the controlled ankle motion boot, return to activity as tolerated, and complications. Three major points were of interest: evidence of improvement in chronic plantar fasciitis when treated with uniport endoscopic procedures; the patient attributes associated with self-reported pain levels 90 days postoperatively; and the patient attributes associated with the average time until patients were able to return to activities as tolerated in a controlled ankle motion boot. It was noted that 44.5% of those with a body mass index of 29.80 kg/m2 or greater reported a postoperative pain level of 0; and 96.3% of those with a body mass index of 25.53 kg/m2 or less reported postoperative pain levels of 0. The analyzed data were used to characterize the clinical outcomes of the procedure, identify changes in outcome with surgeon experience, and identify whether certain patient subgroups have better outcomes, allowing surgeons to identify which patient might be the best candidates for an endoscopic release procedure
Higher Order Terms in the Melvin-Morton Expansion of the Colored Jones Polynomial
We formulate a conjecture about the structure of `upper lines' in the
expansion of the colored Jones polynomial of a knot in powers of (q-1). The
Melvin-Morton conjecture states that the bottom line in this expansion is equal
to the inverse Alexander polynomial of the knot. We conjecture that the upper
lines are rational functions whose denominators are powers of the Alexander
polynomial. We prove this conjecture for torus knots and give experimental
evidence that it is also true for other types of knots.Comment: 21 pages, 1 figure, LaTe
False positive probabilties for all Kepler Objects of Interest: 1284 newly validated planets and 428 likely false positives
We present astrophysical false positive probability calculations for every
Kepler Object of Interest (KOI)---the first large-scale demonstration of a
fully automated transiting planet validation procedure. Out of 7056 KOIs, we
determine that 1935 have probabilities <1% to be astrophysical false positives,
and thus may be considered validated planets. 1284 of these have not yet been
validated or confirmed by other methods. In addition, we identify 428 KOIs
likely to be false positives that have not yet been identified as such, though
some of these may be a result of unidentified transit timing variations. A side
product of these calculations is full stellar property posterior samplings for
every host star, modeled as single, binary, and triple systems. These
calculations use 'vespa', a publicly available Python package able to be easily
applied to any transiting exoplanet candidate.Comment: 20 pages, 8 figures. Published in ApJ. Instructions to reproduce
results can be found at https://github.com/timothydmorton/koi-fp
Neural Network Development for the Forecasting of Upper Atmosphere Parameter Distributions
This paper presents a neural network modeling approach to forecast electron concentration distributions in the 150â 600 km altitude range above Arecibo, Puerto Rico. The neural network was trained using incoherent scatter radar data collected at the Arecibo Observatory during the past two decades, as well as the Kp geomagnetic index provided by the National Space Science Data Center. The data set covered nearly two solar cycles, allowing the neural network to model daily, seasonal, and solar cycle variations of upper atmospheric parameter distributions. Two types of neural network architectures, feedforward and Elman recurrent, are used in this study. Topics discussed include the network design, training strategy, data analysis, as well as preliminary testing results of the networks on electron concentration distributions
Terrestrial Planet Occurrence Rates for the Kepler GK Dwarf Sample
We measure planet occurrence rates using the planet candidates discovered by
the Q1-Q16 Kepler pipeline search. This study examines planet occurrence rates
for the Kepler GK dwarf target sample for planet radii, 0.75<Rp<2.5 Rearth, and
orbital periods, 50<Porb<300 days, with an emphasis on a thorough exploration
and identification of the most important sources of systematic uncertainties.
Integrating over this parameter space, we measure an occurrence rate of F=0.77
planets per star, with an allowed range of 0.3<F<1.9. The allowed range takes
into account both statistical and systematic uncertainties, and values of F
beyond the allowed range are significantly in disagreement with our analysis.
We generally find higher planet occurrence rates and a steeper increase in
planet occurrence rates towards small planets than previous studies of the
Kepler GK dwarf sample. Through extrapolation, we find that the one year
orbital period terrestrial planet occurrence rate, zeta_1=0.1, with an allowed
range of 0.01<zeta_1<2, where zeta_1 is defined as the number of planets per
star within 20% of the Rp and Porb of Earth. For G dwarf hosts, the zeta_1
parameter space is a subset of the larger eta_earth parameter space, thus
zeta_1 places a lower limit on eta_earth for G dwarf hosts. From our analysis,
we identify the leading sources of systematics impacting Kepler occurrence rate
determinations as: reliability of the planet candidate sample, planet radii,
pipeline completeness, and stellar parameters.Comment: 19 Pages, 17 Figures, Submitted ApJ. Python source to support Kepler
pipeline completeness estimates available at
http://github.com/christopherburke/KeplerPORTs
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways. This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes transdifferentiation of ciliated to goblet cells. Thus, EGFR blockade (using an irreversible EGFR kinase inhibitor designated EKB-569) prevents virus-induced increases in ciliated and goblet cells whereas IL-13 blockade (using s-IL-13Rα2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell metaplasia. The distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct epithelial architecture in the setting of airway inflammatory disorders characterized by a similar pattern of chronic EGFR activation, IL-13 expression, and ciliated-to-goblet cell metaplasia
How Should We View the Results of the Multicenter Selective Lymphadenectomy Trial-1 (MSLT-1)?
Planetary Candidates Observed by Kepler. VIII. A Fully Automated Catalog With Measured Completeness and Reliability Based on Data Release 25
We present the Kepler Object of Interest (KOI) catalog of transiting
exoplanets based on searching four years of Kepler time series photometry (Data
Release 25, Q1-Q17). The catalog contains 8054 KOIs of which 4034 are planet
candidates with periods between 0.25 and 632 days. Of these candidates, 219 are
new and include two in multi-planet systems (KOI-82.06 and KOI-2926.05), and
ten high-reliability, terrestrial-size, habitable zone candidates. This catalog
was created using a tool called the Robovetter which automatically vets the
DR25 Threshold Crossing Events (TCEs, Twicken et al. 2016). The Robovetter also
vetted simulated data sets and measured how well it was able to separate TCEs
caused by noise from those caused by low signal-to-noise transits. We discusses
the Robovetter and the metrics it uses to sort TCEs. For orbital periods less
than 100 days the Robovetter completeness (the fraction of simulated transits
that are determined to be planet candidates) across all observed stars is
greater than 85%. For the same period range, the catalog reliability (the
fraction of candidates that are not due to instrumental or stellar noise) is
greater than 98%. However, for low signal-to-noise candidates between 200 and
500 days around FGK dwarf stars, the Robovetter is 76.7% complete and the
catalog is 50.5% reliable. The KOI catalog, the transit fits and all of the
simulated data used to characterize this catalog are available at the NASA
Exoplanet Archive.Comment: 61 pages, 23 Figures, 9 Tables, Accepted to The Astrophysical Journal
Supplement Serie
Planetary Candidates Observed by Kepler IV: Planet Sample From Q1-Q8 (22 Months)
We provide updates to the Kepler planet candidate sample based upon nearly
two years of high-precision photometry (i.e., Q1-Q8). From an initial list of
nearly 13,400 Threshold Crossing Events (TCEs), 480 new host stars are
identified from their flux time series as consistent with hosting transiting
planets. Potential transit signals are subjected to further analysis using the
pixel-level data, which allows background eclipsing binaries to be identified
through small image position shifts during transit. We also re-evaluate Kepler
Objects of Interest (KOI) 1-1609, which were identified early in the mission,
using substantially more data to test for background false positives and to
find additional multiple systems. Combining the new and previous KOI samples,
we provide updated parameters for 2,738 Kepler planet candidates distributed
across 2,017 host stars. From the combined Kepler planet candidates, 472 are
new from the Q1-Q8 data examined in this study. The new Kepler planet
candidates represent ~40% of the sample with Rp~1 Rearth and represent ~40% of
the low equilibrium temperature (Teq<300 K) sample. We review the known biases
in the current sample of Kepler planet candidates relevant to evaluating planet
population statistics with the current Kepler planet candidate sample.Comment: 12 pages, 8 figures, Accepted ApJ Supplemen
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