National Joint Registry of Iran

Joint replacement is currently on the rise with a high community burden. A registry was designed to evaluate the costs, possible complications, and rate of revisions as well as finding the most effective techniques, risk factors associated with poor results, indications for revision surgeries, and also demographic evaluation of patients undergoing joint replacement surgery in Iran. © 2019 BY THE ARCHIVES OF BONE AND JOINT SURGERY

Continues renal replacement therapy (CRRT) with disposable hemoperfusion cartridge: A promising option for severe COVID-19

Cytokine release syndrome is prevalent in severe cases of COVID-19. In this syndrome, an uncontrolled response of immune system occurs. Extracorporeal blood purification has been proven to effectively remove the released inflammatory cytokines. Here, we reported a successful case to represent our experience of extracorporeal blood purification in a patient with severe COVID-19. © 2020 The Author

Study of histopathological lesions in CA1 of the hippocampus after injection of beta-amyloid in a rat model of Alzheimer's disease

BACKGROUND AND OBJECTIVE: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of degenerative dementia with progressive loss of cognitive abilities and memory loss. AD is an irreversible, progressive chronic disease that it is the cause of behavior changes and deterioration of thinking ability. Since exact mechanism of neuro-toxicity by beta amyloid has not been identified yet, in this study, the histopathological lesions in CA1 of hippocampus after injection of beta-amyloid in a rat model of AD was studied. METHODS: In this experimental study, 30 adult male Albino Wistar rats weighing (250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned to three groups; control, sham and β- amyloid (Aβ) injection. The lesion was induced by injection of 4μLof Aβ (1-40) into the hippocampal fissure. For behavioral analysis Y-maze and shuttle box were used respectively at the 14 and 16 days post-lesion. For histological studies, Nissl and Bielschowsky staining were done. FINDINGS: The mean scores of alternation behavior for sham, control, and AD group were 80.56, 86.7, and 46.2, respectively. AD group showed a significant reduction in alternation behavior as compared to control and sham group (p<0.0001). The number of neurons per square millimeter in the Alzheimer group, sham and control, respectively, 2.92, 6.35 and 6.25, and reduced neuronal density in Alzheimer's disease compared with control and sham groups were significant (p<0.0001). CONCLUSION: In the present study, Aβ (1-40) injection into hippocampus could decrease the behavioral indexes and the number of CA1 neurons in hippocampus

Neuropathological changes in brain cortex and hippocampus in a rat model of Alzheimer's disease

Background: Alzheimer's disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned to three groups: control, sham and β-amyloid (Aβ) injection. For behavioral analysis, Y-maze and shuttle box were used, respectively at 14 and 16 days post-lesion. For histological studies, Nissl, modified Bielschowsky and modified Congo red staining were performed. The lesion was induced by injection of 4 μL of Aβ (1-40) into the hippocampal fissure. Results: In the present study, Aβ (1-40) injection into hippocampus could decrease the behavioral indexes and the number of CA1 neurons in hippocampus. Aβ injection CA1 caused Aβ deposition in the hippocampus and less than in cortex. We observed the loss of neurons in the hippocampus and cerebral cortex and certain subcortical regions. Y-maze test and single-trial passive avoidance test showed reduced memory retention in AD group. Conclusion: We found a significant decreased acquisition of passive avoidance and alternation behavior responses in AD group compared to control and sham group (P<0.0001). Compacted amyloid cores were present in the cerebral cortex, hippocampus and white matter, whereas, scattered amyloid cores were seen in cortex and hippocampus of AD group. Also, reduced neuronal density was indicated in AD group

Estimating soil thermal properties from sequences of land surface temperature using hybrid Genetic Algorithm-Finite Difference method

Most models used in land surface hydrology, vadose zone hydrology, and hydro-climatology require an accurate representation of soil thermal properties (soil thermal conductivity and volumetric heat capacity). Various empirical relations have been suggested to estimate soil thermal properties. However, they require many input parameters such as soil texture, mineralogical composition, porosity and water content, which are not always available from laboratory experiments and field measurements. In this paper, to overcome the above challenge, a hybrid numerical method, Genetic Algorithm–Finite Difference (GA–FD), is proposed to estimate soil thermal properties using land surface temperature (LST) as the only input. The genetic algorithm (GA) optimization method coupled with the finite difference (FD) modeling technique is a viable hybrid approach for estimating soil thermal properties. The finite difference method is employed to solve the heat diffusion equation and simulate LST, while a robust optimization technique (GA) is used to retrieve soil thermal properties by minimizing the difference between observed and simulated LST. Furthermore, a generalization of the hybrid model is developed for inhomogeneous soil, in which soil thermal properties are not constant throughout the soil slab. The proposed model is applied to the First International Satellite Land Surface Climatology Project (ISLSCP) Field Experiment (FIFE). The results show that the proposed hybrid numerical method is able to estimate soil thermal properties accurately, and therefore effectively eliminate the need for the unavailable soil parameters which are required by empirical methods for determining the soil thermal conductivity and volumetric heat capacity. Remarkably, the temporal variation of the retrieved soil thermal conductivity is consistent with the volumetric water content, even though no water content information is used in the model

Mesopourous Fe3O4@SiO2-hydroxyapatite nanocomposite: Green sonochemical synthesis using strawberry fruit extract as a capping agent, characterization and their application in sulfasalazine delivery and cytotoxicity

The present study introduces a simple, biocompatible and effective drug delivery system by using mesoporous nanocomposite-based platform. To achieve this goal, mesopourous Fe3O4@SiO2-hydroxyapatite nanocomposite (mFSH) was synthesized by sonochemical process in presence of strawberry fruit extract as capping agent (mFSH-SW). The impact of various factors such as sonication time (5, 15, 30 and 45 min), capping agent (cherry (CH), strawberry (SW), malus domestica (MD), andean blackberry (AB)), pH (10, 11 and 12) and sonication power (30, 60 and 80 W) were investigated to reach optimum condition. To reach high efficiency of drug loading, mFSH was grafted with 3-aminopropyl triethoxysilane (APTES). Uniform, regular and spherical morphology of nanocomposite were specified by field emission scanning electron microscopy (FESEM), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive x-ray spectroscopy (EDX), dynamic light scattering (DLS), nitrogen adsorption/desorption isotherm and Fourier-transform infrared spectroscopy (FT-IR) techniques. The mean pore size, surface area, and pore volume of mFSH-SW were 63.2 m2 g−1, 14.1 nm and 0.24 cm3 g−1, respectively. Sulfasalazine (SLN) loading and release were carried out by various products. The functionalized mFSH-SW showed high adsorption capacity (approximately 59.1 ) for SLN that possesses amino functional groups. The results showed that 100 of SLN-loaded nanocomposite could be released after 36 h at intestinal conditions (pH = 6.8). In addition, in-vitro and in-vivo toxicity investigations of product were performed with apoptosis/necrosis, XTT and pathology assay, respectively. All in all, unique properties of the nanocomposite including low toxicity, high drug loading, slow release and biodegradable showed that it can be used in biomedical sciences. © 2020 Elsevier B.V

Biogenic and eco-benign synthesis of silver nanoparticles using jujube core extract and its performance in catalytic and pharmaceutical applications: Removal of industrial contaminants and in-vitro antibacterial and anticancer activities

Biosynthesis of nanoparticles has been rapidly developed in various fields, due to their broad spectrum of applications in the fields of environmental, pharmacology, and medicine. In this study, facile, rapid, eco-friendly and cost-effective method was used to green synthesis of silver nanoparticles (AgNPs) using jujube core extract (AgNPs-JCE) and then used as antibacterial, anticancer and catalytic agents. The reaction parameters such as AgNO 3 concentration (1, 5, 10, 20 and 40 mM), reaction time (5, 30 and 60 min) and pH (without pH, 10 and 12) were discussed and optimized. The surface plasmon resonance peak at about 420 nm in the UV–Vis absorption spectrum confirmed the green synthesis of silver nanoparticles. Microscopic results revealed that the synthesized AgNPs-JCE were spherical in morphology with a size range of 25–35 nm.In addition, the subject AgNPs promising catalytic properties in the degradation of pollutants including rhodamine b (RhB) and eriochrome black T (EBT) as cationic and anionic contaminant under UV and visible light irradiations. The photocatalyst (AgNPs-JCE) exhibited the degradation of 90.9 % and 84.7% for RhB and EBT contaminants after 80 min under UV irradiation, respectively. The antibacterial activities of AgNPs-JCE was checked against E. coli as Gram-positive bacteria and K. pneumoniae and S. aureus as Gram-negative bacteria with MIC and MBC values of (1.26 and 1.26 g/ml), (2.5 and 2.5 g/ml), and (2.5 and 10 g/ml), respectively. Finally, the cytotoxicity of synthesized nanoparticles against AGS as human stomach cancer cell line was determined at several concentrations (2.5, 5, 10, 20, 50, and 100 g/ml) using MTT assay. Finding of this research suggested the suitability of AgNPs-JCE as pollutants degradation, antibacterial and anticancer drug development