Patient cancer information seeking preferences by age and source: A comparison of the 2003, 2005, and 2007 Health Information National Trends Survey

Title: Patient Cancer Information Seeking Preferences by Age and Source: A Comparison of the 2003, 2005, and 2007 Health Information National Trends Survey Purpose/Procedure: Patient education enhances the patient's ability to actively participate in the healthcare decisions leading to an improved level of understanding. Modern technology provides society with access to a seemingly unlimited number of informative resources. Most Americans are bombarded with information from all angles; through newspapers, magazines, television, advertising, and especially the Internet. Therefore when an illness arises, a wide variety of information sources are readily available to most individuals. The rapid advancement of technology over the past decade has potentially created a generation gap in accessing information from the Internet. Older individuals may not have the same resources or skills as those in the younger generation in reference to obtaining electronic medical information. The purpose of this retrospective, secondary data analysis of information obtained from the 2003, 2005 and 2007 Health Information National Trends Survey (HINTS) conducted by the National Cancer Institute (NCI) is to compare the frequencies of patient cancer information seeking preferences by age ranges and source to evaluate the self-reported trust level of the participants in reference to the medical information provided. Results: 66% of participants claim to have never searched for cancer information in 2007, but 77% did search for some type of healthcare information. In 2003 the most common primary sources of cancer information were the Internet, books, and a healthcare provider. By 2007 the 4 library was cited as the most utilized source and a healthcare provider was one of the least cited sources. Overall the participants aged 18 - 49 years were more likely to first search for medical information at the library, while participants aged 50 and above cited the Internet as a primary resource. As participants grew older, they were also more likely to seek cancer information from a healthcare provider, magazines, and the radio. Participants who did seek cancer information appear evenly divided regarding concerns about the quality of the information sought. The most trusted source of cancer information was reported to be a doctor and the least trusted source was the radio. Conclusions: • Since 2003, patients have shifted to searching first in a Library or Book before the Internet. • Healthcare providers and Magazines dropped from being one of the first searched places to one of the last. • This study showed a trend of older age groups preferences to use the Internet as a primary source of information. • The Library was used as a primary source for those 18-34 and 35-49 • As participants grew older, they were more likely to approach a healthcare provider. • Participants showed the most trust in Physicians as a source. • The least reliable source from the survey results was the Radio. • The Internet evolved and changed in trust levels over the course of the 3 surveys.No embarg

Lisocabtagene maraleucel in follicular lymphoma: The phase 2 TRANSCEND FL study

An unmet need exists for patients with relapsed/refractory (R/R) follicular lymphoma (FL) and high-risk disease features, such as progression of disease within 24 months (POD24) from first-line immunochemotherapy or disease refractory to both CD20-targeting agent and alkylator (double refractory), due to no established standard of care and poor outcomes. Chimeric antigen receptor (CAR) T cell therapy is an option in R/R FL after two or more lines of prior systemic therapy, but there is no consensus on its optimal timing in the disease course of FL, and there are no data in second-line (2L) treatment of patients with high-risk features. Lisocabtagene maraleucel (liso-cel) is an autologous, CD19-directed, 4-1BB CAR T cell product. The phase 2 TRANSCEND FL study evaluated liso-cel in patients with R/R FL, including 2L patients who all had POD24 from diagnosis after treatment with anti-CD20 antibody and alkylator ≤6 months of FL diagnosis and/or met modified Groupe d\u27Etude des Lymphomes Folliculaires criteria. Primary/key secondary endpoints were independent review committee-assessed overall response rate (ORR)/complete response (CR) rate. At data cutoff, 130 patients had received liso-cel (median follow-up, 18.9 months). Primary/key secondary endpoints were met. In third-line or later FL (n = 101), ORR was 97% (95% confidence interval (CI): 91.6‒99.4), and CR rate was 94% (95% CI: 87.5‒97.8). In 2L FL (n = 23), ORR was 96% (95% CI: 78.1‒99.9); all responders achieved CR. Cytokine release syndrome occurred in 58% of patients (grade ≥3, 1%); neurological events occurred in 15% of patients (grade ≥3, 2%). Liso-cel demonstrated efficacy and safety in patients with R/R FL, including high-risk 2L FL. ClinicalTrials.gov identifier: NCT04245839

A model of the crustal magnetic field of Mars

Das Magnetfeld des Mars hat seinen Ursprung v.a. in der remanenten Magnetisierung seiner Kruste und besitzt heute kein globales Dipolfeld mehr. In dieser Arbeit werden Magnetfeldmessungen des Satelliten "Mars Global Surveyor" (MGS) benutzt, um ein robustes und hochauflösendes Modell dieses Krustenfeldes abzuleiten. Dies wurde durch die Annäherung einer L1-Norm zur Regularisierung, einer robusten Norm zur Inversion, der Berücksichtigung externer Felder, sowie einer genauen Analyse und Gewichtung aller vorhandenen MGS-Magnetfelddaten erreicht. Das resultierende Modell kann zur Beantwortung offener Fragen der Evolution des Mars beitragen. Exemplarisch wurden dazu das Krustenfeld von Vulkanen und Impaktkratern analysiert, um Rückschlüsse auf den Zeitpunkt eines aktiven Kerndynamos zu schliessen. Darüber hinaus wird ein Modell der benötigten Krustenmagnetisierung vorgestellt sowie auf isolierte Anomalien eingegangen, die bei der Bestimmung von magnetischen Paleopolen eine Rolle spielen.The main source of the Martian magnetic field is of crustal origin, and Mars does not possess an internal core dynamo as of today. In this thesis, we use magnetic field data as obtained by the satellite "Mars Global Surveyor" (MGS) in order to derive a robust model of the crustal magnetic field of Mars with high resolution. For this purpose, we use an approximation to an L1 norm for regularization, a robust norm for data inversion, an external field model, and a precise analysis and weighting of all available MGS magnetic field data. The resulting model may contribute to answer open questions related to the evolution of Mars. Here, we exemplarily analyze the crustal magnetic field of volcanoes and impact craters, and this analysis is used to conclude on the timing of an ancient Martian core dynamo. Further, we present a model of the necessary magnetization of the Martian crust, and we comment on some isolated anomalies that are required to calculate magnetic paleopole positions.<br

Vegetation of the Dolines in Mecsek Mountains (South Hungary) in relation to the Local Plant Communities

This paper deals with the forest vegetation of the lower part of the dolines in Mecsek Mts. (South Hungary). In order to char-acterize this vegetation type, samples were compared to the 6 plant communities occurring in the neighbourhood of the dolines. Considering the vegetation texture and species com-position, the vegetation of the dolines resembles mainly the extrazonal beechwoods (Helleboro odori-fagetum) and local ravine forests (Scutellario altissimae-Aceretum) that preserve several mountain, subatlantic relict species in this area. Our study revealed that the plant communities characteristic of the karst surface of Western Mecsek are arranged along a moisture and nutrient gradient. In this system, the habitat conditions of the dolines are similar to those of the beech forests and the lo-cal ravine forests, fresh and relatively rich in nutrients. In the karst, dominated by oak-hornbeam and beech forests, effects of the thermal inversion are the most spectacular where beech forests follow turkey oak-sessile oak forests and oak-hornbeam forests on the lower part of the doline slopes. The described vegetation type of these depressions is developed by edafic fac-tors; its identification as a separate association is not supported by the analyses

Isoecological curves on characterising the ecotypes central Mecsaek MTS of Hungary

Ecological indicator values, widely used botany, are empricial scales worked out for the most important factors. Values of enviromental factors determine the position of the vegetation units in a multidimensional abstarct space. Their latest version in Hungary is the catergory system of Borhidi (1995), which is adjusted ti the European systems (e. g. Ellenberg et al. 1992). Indicator values or categories, respectively, can be found, according to European practice, in a relational computerised database (Horváth et al. 1995) which is accpeted as a standard for the botanists.             An example of isoline analysis, completed using ecological indicator values of vegetation samples, is presented on a modell area in Mecsek Mts of South Hungary. It has varied vegetation with diverse kind of human interference near Pécs. From the existing indicator values applied here temperatur (TB), water demand (WB) of plants and soil reaction (RB). Each single isocurve was constructed from the similar indicator values on a computerised way (Surfer 6.1). All the curves were made by the use of avarages, single values and certain groups of ecological indicator values. Only the figures amde by the avarages are presented here, because there is no additional unformation in the case of the use of single curves.             Curves of temperature and water indicators (isoTB, isoWB) show climatic conditions changed by human impact. Curves of soil reaction (isoR) show in a given moment the actual vegetation, in time dimension that parts of enviroment wich are more sensitive to acidification.             Analysing isoecological curves, human impact is easily recognisable (e.g. in surroundings of clear-cuttings, etc.). On the basis of our results added to monitoring system enviromental impacts of future industrial and forestry establishments can be modelled. Isolines, using above-mentioned indicator values help to reveal and quantify enviromental change, which is model-valued posibility for preparing enviromental impact studies and making quick decisions