Self-esteem (Rosberg). Outcomes measurement tool: attitudes & feelings - self esteem.

Self-esteem reflects a person's overall subjective emotional evaluation of his or her own worth. The scale measures state self-esteem by asking the respondents to reflect on their current feelings. The scale is a 10-item self-report measure of global self-esteem. It consists of 10 statements related to overall feelings of self-worth or self-acceptance. The items are answered on a four-point scale ranging from strongly agree to strongly disagree. The SES has also been administered as an interview

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-specific stimulator YC-1 induce a 71° rotation of the heme-binding β H-NOX and PAS domains. Repositioning of the β H-NOX domain leads to a straightening of the coiled-coil domains, which, in turn, use the motion to move the catalytic domains into an active conformation. YC-1 binds directly between the β H-NOX domain and the two CC domains. The structural elongation of the particle observed in cryo-EM was corroborated in solution using small angle X-ray scattering (SAXS). These structures delineate the endpoints of the allosteric transition responsible for the major cyclic GMP-dependent physiological effects of NO

Child abuse, child protection and disabled children : a review of recent research

This paper reports the results of a scoping study which reviewed research about child abuse, child protection and disabled children published in academic journals between 1996 - 2009. The review was conducted using a five stage method for scoping studies. Several studies have revealed a strong association between disability and child maltreatment, indicating that disabled children are significantly more likely to experience abuse than their non-disabled peers. Those with particular impairments are at increased risk. There is evidence that the interaction of age, gender and/or socio-cultural factors with impairment results in different patterns of abuse to those found among non-disabled children although the reasons for this require further examination. It appears that therapeutic services and criminal justice systems often fail to take account of disabled children's needs and heightened vulnerability. In Britain, little is known about what happens to disabled children who have been abused and how well safeguarding services address their needs. Very few studies have sought disabled children's own accounts of abuse or safeguarding. Considerable development is required, at both policy and practice level, to ensure that disabled children's right to protection is upheld. The paper concludes by identifying a number of aspects of the topic requiring further investigation

Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection

There was no study funding. We are grateful to Tony Rafferty (Tailored Information for the People of Scotland, TIPs) for providing survival data.Peer reviewedPublisher PD

Testing causality violation on spacetimes with closed timelike curves

Generalized quantum mechanics is used to examine a simple two-particle scattering experiment in which there is a bounded region of closed timelike curves (CTCs) in the experiment's future. The transitional probability is shown to depend on the existence and distribution of the CTCs. The effect is therefore acausal, since the CTCs are in the experiment's causal future. The effect is due to the non-unitary evolution of the pre- and post-scattering particles as they pass through the region of CTCs. We use the time-machine spacetime developed by Politzer [1], in which CTCs are formed due to the identification of a single spatial region at one time with the same region at another time. For certain initial data, the total cross-section of a scattering experiment is shown to deviate from the standard value (the value predicted if no CTCs existed). It is shown that if the time machines are small, sparsely distributed, or far away, then the deviation in the total cross-section may be negligible as compared to the experimental error of even the most accurate measurements of cross-sections. For a spacetime with CTCs at all points, or one where microscopic time machines pervade the spacetime in the final moments before the big crunch, the total cross-section is shown to agree with the standard result (no CTCs) due to a cancellation effect.Comment: 28 pages, 8 figures, late

The Local Emergence and Global Diffusion of Research Technologies: An Exploration of Patterns of Network Formation

Grasping the fruits of "emerging technologies" is an objective of many government priority programs in a knowledge-based and globalizing economy. We use the publication records (in the Science Citation Index) of two emerging technologies to study the mechanisms of diffusion in the case of two innovation trajectories: small interference RNA (siRNA) and nano-crystalline solar cells (NCSC). Methods for analyzing and visualizing geographical and cognitive diffusion are specified as indicators of different dynamics. Geographical diffusion is illustrated with overlays to Google Maps; cognitive diffusion is mapped using an overlay to a map based on the ISI Subject Categories. The evolving geographical networks show both preferential attachment and small-world characteristics. The strength of preferential attachment decreases over time, while the network evolves into an oligopolistic control structure with small-world characteristics. The transition from disciplinary-oriented ("mode-1") to transfer-oriented ("mode-2") research is suggested as the crucial difference in explaining the different rates of diffusion between siRNA and NCSC