Effect of processing temperature on utilization of whole soybeans by young calves

Two trials were conducted to determine the optimum conditions for processing whole soybeans for young calves. In the first trial, laboratory procedures and a nitrogen balance study were used. This information was used to design the second trial in which raw and processed soybeans were evaluated in an 8-wk growth trial using 96 Holstein day-old calves. Starters contained soybean meal (SBM), SBM with added fat, raw soybeans, or soybeans processed at 280, 340, or 375°F in a California Pellet Mill Jet-Sploder. Calves fed the starters containing soybeans processed at 340 consumed more feed, gained faster, had lower fecal scores (less scours), and less mortality.; Dairy Day, 1984, Kansas State University, Manhattan, KS, 1984

Effect of processing temperature on utilization of whole soybeans by young calves

Two trials were conducted to determine the optimum conditions for processing whole soybeans for young calves. In the first trial, laboratory procedures and a nitrogen balance study were used. This information was used to design the second trial in which raw and processed soybeans were evaluated in an 8-wk growth trial using 96 Holstein day-old calves. Starters contained soybean meal (SBM), SBM with added fat, raw soybeans, or soybeans processed at 280, 340, or 375°F in a California Pellet Mill Jet-Sploder. Calves fed the starters containing soybeans processed at 340 consumed more feed, gained faster, had lower fecal scores (less scours), and less mortality.; Dairy Day, 1984, Kansas State University, Manhattan, KS, 1984

Non-crossing dependencies: Least effort, not grammar

The use of null hypotheses (in a statistical sense) is common in hard sciences but not in theoretical linguistics. Here the null hypothesis that the low frequency of syntactic dependency crossings is expected by an arbitrary ordering of words is rejected. It is shown that this would require star dependency structures, which are both unrealistic and too restrictive. The hypothesis of the limited resources of the human brain is revisited. Stronger null hypotheses taking into account actual dependency lengths for the likelihood of crossings are presented. Those hypotheses suggests that crossings are likely to reduce when dependencies are shortened. A hypothesis based on pressure to reduce dependency lengths is more parsimonious than a principle of minimization of crossings or a grammatical ban that is totally dissociated from the general and non-linguistic principle of economy.Postprint (author's final draft

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis

Background: Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden cardiac death (SCD) risk. While the genetics of arrhythmia syndromes have been studied, relations between electrocardiographic intervals and rare genetic variation at a population level are poorly understood. Methods: Using a discovery sample of 29 000 individuals with whole-genome sequencing from Trans-Omics in Precision Medicine and replication in nearly 100 000 with whole-exome sequencing from the UK Biobank and MyCode, we examined associations between low-frequency and rare coding variants with 5 routinely measured electrocardiographic traits (RR, P-wave, PR, and QRS intervals and corrected QT interval). Results: We found that rare variants associated with population-based electrocardiographic intervals identify established monogenic SCD genes (KCNQ1, KCNH2, and SCN5A), a controversial monogenic SCD gene (KCNE1), and novel genes (PAM and MFGE8) involved in cardiac conduction. Loss-of-function and pathogenic SCN5A variants, carried by 0.1% of individuals, were associated with a nearly 6-fold increased odds of the first-degree atrioventricular block (P=8.4×10-5). Similar variants in KCNQ1 and KCNH2 (0.2% of individuals) were associated with a 23-fold increased odds of marked corrected QT interval prolongation (P=4×10-25), a marker of SCD risk. Incomplete penetrance of such deleterious variation was common as over 70% of carriers had normal electrocardiographic intervals. Conclusions: Our findings indicate that large-scale high-depth sequence data and electrocardiographic analysis identifies monogenic arrhythmia susceptibility genes and rare variants with large effects. Known pathogenic variation in conventional arrhythmia and SCD genes exhibited incomplete penetrance and accounted for only a small fraction of marked electrocardiographic interval prolongation

Effect of processing temperature on utilization of whole soybeans by young calves

Two trials were conducted to determine the optimum conditions for processing whole soybeans for young calves. In the first trial, laboratory procedures and a nitrogen balance study were used. This information was used to design the second trial in which raw and processed soybeans were evaluated in an 8-wk growth trial using 96 Holstein day-old calves. Starters contained soybean meal (SBM), SBM with added fat, raw soybeans, or soybeans processed at 280, 340, or 375°F in a California Pellet Mill Jet-Sploder. Calves fed the starters containing soybeans processed at 340 consumed more feed, gained faster, had lower fecal scores (less scours), and less mortality

Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents

The authors thank the Royal Society for a University Research Fellowship (ADS), The Carnegie Trust for the Universities of Scotland (LCM), Syngenta/EPSRC (Case award to DGS), GSK/EPSRC (CASE award to SRS), the EU (IEF for CS), and the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement no. 279850 (JET) for funding.Isothiourea HBTM-2.1 catalyses the Michael addition-lactonisation of 2-aryl and 2-alkenylacetic acids and α,β-unsaturated trichloromethyl ketones. Ring-opening of the resulting dihydropyranones and subsequent alcoholysis of the CCl ketone with an excess of methanol gives a range of diesters in high diastereo- and enantioselectivity (up to 95:5 dr and >99% ee). Sequential addition of two different nucleophiles to a dihydropyranone gives the corresponding differentially substituted diacid derivative.PostprintPeer reviewe