Une politique documentaire pour la collection des ouvrages de référence de la BCU Centrale de Fribourg: premières étapes

Ce travail propose une redéfinition de la collection de référence de la Bibliothèque Cantonale et Universitaire de Fribourg (BCU) se trouvant dans les espaces publics de la Bibliothèque Centrale. Cette restructuration concerne autant les missions de la collection (et par conséquence son contenu et son public) que sa gestion. Ainsi, après avoir rapidement présenté la BCU, situé la collection en rapport au fonds de la Centrale et établi un état de lieu de la collection et de sa gestion, l'auteur présente deux textes constituant la première étape pour une politique documentaire rédigée de la collection. Dans les détails, sa proposition, se basant sur le modèle de Calenge, est constituée par une charte de la collection et un plan de développement pour l'année 2014

An Open RAN Framework for the Dynamic Control of 5G Service Level Agreements

The heterogeneity of use cases that next-generation wireless systems need to support calls for flexible and programmable networks that can autonomously adapt to the application requirements. Specifically, traffic flows that support critical applications (e.g., vehicular control or safety communications) often come with a requirement in terms of guaranteed performance. At the same time, others are more elastic and can adapt to the resources made available by the network (e.g., video streaming). To this end, the Open Radio Access Network (RAN) paradigm is seen as an enabler of dynamic control and adaptation of the protocol stack of 3rd Generation Partnership Project (3GPP) networks in the 5th Generation (5G) and beyond. Through its embodiment in the O-RAN alliance specifications, it introduces the Ran Intelligent Controllers (RICs), which enable closed-loop control, leveraging a rich set of RAN Key Performance Measurements (KPMs) to build a representation of the network and enforcing dynamic control through the configuration of 3GPP-defined stack parameters. In this paper, we leverage the Open RAN closed-loop control capabilities to design, implement, and evaluate multiple data-driven and dynamic Service Level Agreement (SLA) enforcement policies, capable of adapting the RAN semi-persistent scheduling patterns to match users requirements. To do so, we implement semi-persistent scheduling capabilities in the OpenAirInterface (OAI) 5G stack, as well as an easily extensible and customizable version of the Open RAN E2 interface that connects the OAI base stations to the near-real-time RIC. We deploy and test our framework on Colosseum, a large-scale hardware-in-the-loop channel emulator. Results confirm the effectiveness of the proposed Open RAN-based solution in managing SLA in near-real-time

Lithium disilicate posterior overlays: clinical and biomechanical features

The aim of this study was to evaluate the survival rate of lithium disilicate overlays in increasing occlusal vertical dimension (OVD) in the setting of minimally invasive techniques and the restoration thicknesses at different tooth sites. This is an observational study evaluating 43 lithium disilicate overlays (Lithium IPS e.max Press, Ivoclar Vivadent) on 8 patients, prepared with minimally invasive criteria over a follow-up period between 19 to 45 months (mean follow-up of 32 months). Occlusal vertical dimension's increase was planned using occlusal treatment plan and diagnostic wax-up. Prior to adhesive cementation, restoration thicknesses were measured with a caliber. The survival rate was calculated by Kaplan-Meier analysis. Restoration survival rates at 32 months were 97.7%. One infiltration was observed, no cases of fracture occurred. The greatest thickness in monolithic restorations was detected in the cusp sides of teeth, whereas the thinnest was highlighted in the central fossa. The average amount of dental tissue removed during preparation was 0.98 mm in non-functional cusps, 0.88 mm in functional cusps, and 0.57 mm in the central fossa. Lithium disilicate posterior overlays show an excellent complication-free survival rate, and the material allows for conservative restorations with minimum thickness. Monolithic lithium disilicate overlays feature a satisfying 32-month survival rate. The technique allows to perform restorations with a minimal removal of dental tissue, while limiting fractures over time. Its esthetical performance is excellent

Clinical and Esthetical Evaluation of 79 Lithium Disilicate Multilayered Anterior Veneers with a Medium Follow-Up of 3 Years

Objectives Primary aim of this study was to evaluate survival rate of lithium disilicate veneers in upper and lower anterior teeth. Secondary aims were to evaluate changing in proportions of teeth before and after restorations and to assess mean thickness of the veneers. Materials and Methods Seventy-nine upper and lower lithium disilicate veneers were made in 13 patients with worn teeth. Mean follow-up was 3 years. To perform anterior definitive rehabilitations, malocclusions and loss of vertical dimension were treated by full mouth rehabilitations to obtain proper occlusal conditions. Veneers were made of lithium disilicate core and fluorapatite-based ceramic stratification. Survival rate was calculated by Kaplan-Meier analysis. Changing in teeth proportion before and after restorations was analyzed by a paired t -test. Descriptive statistics of thickness values were also performed. Results One case of detachment was observed with a 98.7% survival rate. Teeth's proportions were preserved although the first upper right incisor and canine changed in dimension. Conclusions Lithium disilicate veneers in esthetical rehabilitations of worn teeth proved to be an effective way of treatment in a medium follow-up of 3 years. Proportions seemed to be maintained with a minimum dental removal

The Impact of Obesity on Wages: the Role of Personal Interactions and Job Selection

We estimate the effects of obesity on wages accounting for the workers' sorting into jobs requiring different levels of personal interactions in the workplace. Using data from the National Longitudinal Survey of Youth 1979 combined with detailed information about jobs from O*Net, we find a wage penalty for obese white women. This penalty is higher in jobs that require a high level of personal interactions. Accounting for job selection does not significantly change the estimated wage penalty

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach

The use and misuse of antibiotics has resulted in critical conditions for drug-resistant bacteria emergency, accelerating the development of antimicrobial resistance (AMR). In this context, the co-administration of an antibiotic with a compound able to restore sufficient antibacterial activity may be a successful strategy. In particular, the identification of efflux pump inhibitors (EPIs) holds promise for new antibiotic resistance breakers (ARBs). Indeed, bacterial efflux pumps have a key role in AMR development; for instance, NorA efflux pump contributes to Staphylococcus aureus (S. aureus) resistance against fluoroquinolone antibiotics (e.g., ciprofloxacin) by promoting their active extrusion from the cells. Even though NorA efflux pump is known to be a potential target for EPIs development, the absence of structural information about this protein and the little knowledge available on its mechanism of action have strongly hampered rational drug discovery efforts in this area. In the present work, we investigated at the molecular level the substrate recognition pathway of NorA through a Supervised Molecular Dynamics (SuMD) approach, using a NorA homology model. Specific amino acids were identified as playing a key role in the efflux pump-mediated extrusion of its substrate, paving the way for a deeper understanding of both the mechanisms of action and the inhibition of such efflux pumps

Neuronal desertification after a direct lightning strike: a case report

Background: Lightning strike is a rare but dramatic cause of injury. Patients admitted to intensive care units (ICUs) with lightning strike frequently have a high mortality and significant long-term morbidity related to a direct brain injury or induced cardiac arrest (CA). Case presentation: A 50-year-old Caucasian man was admitted to our hospital after being struck by lightning resulting in immediate CA. Spontaneous circulation was initially restored, and the man was admitted to the ICU, but ultimately died while in hospital due to neurological injury. The computer tomography scan revealed a massive loss of grey-white matter differentiation at the fronto-temporal lobes bilaterally. Somatosensory-evoked potentials demonstrated bilateral absence of the cortical somatosensory N20-potential, and the electroencephalogram recorded minimal cerebral electrical activity. The patient died on day 10 and a post-mortem study revealed a widespread loss of neurons. Conclusion: This case study illustrates severe brain injury caused by a direct lighting strike, with the patient presenting an extraordinary microscopic pattern of neuronal desertification

SCL-90 empirical factors predict post-surgery weight loss in bariatric patients over longer time periods

This longitudinal study examined how pre-intervention psychological health helps predict bariatric surgery (BS) success as percentage of expected body mass index loss (ëMIL) over shorter to longer periods

Conceptual Design of the Steam Generators for the EU DEMO WCLL Reactor

In the framework of the EUROfusion Horizon Europe Programme, ENEA and its linked third parties are in charge of the conceptual design of the steam generators belonging to EU DEMO WCLL Breeding Blanket Primary Heat Transfer Systems (BB PHTSs). In particular, in 2021, design activities and supporting numerical simulations were carried out in order to achieve a feasible and robust preliminary concept design of the Once Through Steam Generators (OTSGs), selected as reference technology for the DEMO Balance of Plant at the end of the Horizon 2020 Programme. The design of these components is very challenging. In fact, the steam generators have to deliver the thermal power removed from the two principal blanket subsystems, i.e., the First Wall (FW) and the Breeding Zone (BZ), to the Power Conversion System (PCS) for its conversion into electricity, operating under plasma pulsed regime and staying in dwell period at a very low power level (decay power). Consequently, the OTSG stability and control represent a key point for these systems' operability and the success of a DEMO BoP configuration with direct coupling between the BB PHTS and the PCS. In this paper, the authors reported and critically discussed the FW and BZ steam generators' thermal-hydraulic and mechanical design, the developed 3D CAD models, as well as the main results of the stability analyses and the control strategy to be adopted