Investigating the inclusive transverse spectra in high-energy pppp collisions in the context of geometric scaling framework

The presence of geometric scaling within the $p_T$ spectra of produced hadrons at high energy $pp$ collisions using small-$x$ $k_T$-factorization is investigated. It is proposed a phenomenological parameterization for the unintegrated gluon distribution in the scaling range which reproduces the features of the differential cross section both in the saturated and dilute perturbative QCD regimes. As the saturation scale acts as an effective regulator of the infrared region (IR), the extension of the model to quantities usually associated to soft physics is studied. The approach is applied to compute the average $p_T$ and the rapidity distribution of produced gluons at high energies.Comment: 11 pages, 9 figure

Nuclear Modification Factor in Small System Collisions within Perturbative QCD Including Thermal Effects

In this paper, dedicated to the memory of the late Prof. Jean Cleymans, the nuclear modification factors, $R_{xA}$, are investigated for pion production in small system collisions, measured by PHENIX experiment at RHIC (Relativistic Heavy Ion Collider). The theoretical framework is the transverse momentum $k_T$-factorization formalism for hard processes at small momentum fraction, $x$. Evidence for collective expansion and thermal effects for pions, produced at equilibrium, is studied based on phenomenological parametrization of blast-wave type in the relaxation time approximation. The dependencies on the centrality and on the projectile species are discussed in terms of the behavior of Cronin peak and the suppression of $R_{xA}$ at large transverse momentum, $p_T$. The multiplicity of produced particles, which is sensitive to the soft sector of the spectra, is also included in the present analysis.Comment: 12 pages, 4 figures. Contribution to MDPI Physics Special Issue "Jean Cleymans: A Life for Physics", dedicated to the memory of Professor Jean Cleyman

Investigating the diffractive gluon jet production in lepton-ion collisions

We study the diffractive jet production in electron-ion collisions in the kinematical region where the mass $M_X$ of the diffractive final state is larger than $Q^2$. Based on parton saturation framework predictions are done for the kinematics of future or possible $eA$ machines as the EIC, LHeC, HE-LHeC and FCC-eA. We analyze the differential cross section as a function of jet (gluon) transverse momentum and from the experimental point of view this observable could be used to extract the saturation scale as a function of $x_{I\!\!P}$.Comment: 8 pages, 5 figures. To be published in Physical Review

Role of nuclear gluon distribution on particle production in heavy ion collisions

The transverse momentum spectra of hadrons is calculated from the unintegrated gluon distribution (UGD) within the $k_T$-factorization framework at small $x$. Starting from $pp$ collisions, the modification caused by the nuclear medium is incorporated in the UGD at high energies, which is related to the nuclear shadowing phenomenon. Moreover, we consider that particle production from minijet decaying is not enough to explain the $p_T$ spectra in $AA$ collisions due to collective phenomena that take place after the hard collision. The Boltzmann-Gibbs Blast Wave (BGBW) distribution is utilized in order to evaluate the distribution of particle production in equilibrium. Data from ALICE collaboration for $PbPb$ collisions at $\sqrt{s}=2.76$ TeV are analyzed and the nuclear modification factor for pion production is computed.Comment: 8 pages, 5 figure

Dilepton production through timelike Compton scattering within the kTk_T-factorization approach

In this work we consider the dilepton production via timelike Compton scattering (TCS) in electron-proton and proton-proton collisions. In particular, the differential cross section in terms of the dilepton invariant mass and rapidity is computed within the $k_T$-factorization approach. Besides, we utilize distinct unintegrated gluon distributions (UGD) in order to compare their impact on the differential cross section of TCS in $pp$ ($ep$) collisions evaluated at the LHC (LHeC), HL-LHC (LHeC), HE-LHC (LHeC) and FCC-hh (eh) center-of-mass energies.Comment: 9 pages, 4 figure

Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study

This study utilizes 2D-DIGE (difference gel etrophoresis), isotope-coded protein labeling and biochemical assays to characterize protein alteration in ulcerative colitis (UC) and Crohn's disease (CD) in human epithelial cell and mucosal biopsies in inflammatory bowel disease (IBD)-affected patients. The aim of this study is to identify the key molecular signatures involved in epithelial cell structure of IBDs. In non-inflamed UC (QUC) keratins, vimentin, and focal adhesion kinase (7) increased, whereas vinculin and de-tyrosinated \uce\ub1-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being collagen type VI alpha 1 chain (COL6A1), tenascin-C and vimentin increased. In non-inflamed CD (QCD), tenascin C, de-tyrosinated \uce\ub1-tubulin, vinculin, FAK, and Rho-associated protein kinase 1 (ROCK1) decreased while vimentin increased. In inflamed CD (ICD), COL6A1, vimentin and integrin alpha 4 increased. In QUC, cell metabolism is characterized by a decrease of the tricarboxylic acid cycle enzymes and a decrease of short/branched chain specific acyl-CoA dehydrogenase, fatty acid synthase, proliferator-activated receptors alpha, and proliferator-activated receptors gamma. In QCD a metabolic rewiring occurs, as suggested by glycerol-3-phosphate dehydrogenase (GPD2), pyruvate dehydrogenase E1 component subunit beta, NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, and 4-trimethylaminobutyraldehyde dehydrogenase increment, while dihydrolipoyl dehydrogenase decreased. Macroautophagy is activated in QUC and IUC, with increased levels of p62, HSC70, major vault protein, myosin heavy chain 9, whereas it is blunted in QCD and ICD. The differing pattern of extracellular matrix, cytoskeletal derangements, cellular metabolism, and autophagy in UC and CD may contribute to the pathophysiological understanding of these disorders and serve as diagnostic markers in IBD patients

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Children and adolescents with haematological malignancies (pedHM) are characterized by a severe loss of exercise ability during cancer treatment, lasting throughout their lives once healed and impacting their social inclusion prospects. The investigation of the effect of a precision-based exercise program on the connections between systems of the body in pedHM patients is the new frontier in clinical exercise physiology. This study is aimed at evaluating the effects of 11 weeks (3 times weekly) of combined training (cardiorespiratory, resistance, balance and flexibility) on the exercise intolerance in PedHM patients. Two-hundred twenty-six PedHM patients were recruited (47% F). High or medium frequency participation (HAd and MAd) was considered when a participant joined; > 65% or between 30% and < 64% of training sessions, respectively. The \u201cup and down stairs\u2019\u2019 test (TUDS), \u201c6 min walking\u201d test (6MWT), the \u201c5 Repetition Maximum strength\u201d leg extension and arm lateral raise test (5RM-LE and 5RM-ALR), flexibility (stand and reach), and balance (stabilometry), were performed and evaluated before and after training. The TUDS, the 5RM-LE and 5RM-ALR, and the flexibility exercises showed an increase in HAd and MAd groups (P < 0.05), while the 6MWT and balance tests showed improvement only in HAd group (P < 0.0001). these results support the ever\u2010growing theory that, in the case of the treatment of PedHM, \u2018exercise is medicine\u2019 and it has the potential to increase the patient\u2019s chances of social inclusion

Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis

10.1260/2040-2295.4.1.23Journal of Healthcare Engineering4123-4