Random walk and gap plots of DNA sequences

Genomic sequence analysis is usually performed with the help of specialized software packages written for molecular biologists. The scope of such pre-programmed techniques is quite limited. Because DNA sequences contain a large amount of information, analysis of such sequences without underlying assumptions may provide additional insights. The present article proposes two new graphical representations as examples of such methods. The random walk plot is designed to show the base composition in a compact form, whereas the gap plot visualizes positional correlations. The random walk plot represents the DNA sequence as a curve, a random walk, in a plane. The four possible moves, left/right and up/down, are used to encode the four possible bases. Gap plots provide a tool to exhibit various features in a sequence. They visualize the periodic patterns within a sequence, both with regard to a single type of base or between two types of base

A survey of robust statistics

We argue that robust statistics has multiple goals, which are not always aligned. Robust thinking grew out of data analysis and the realisation that empirical evidence is at times supported merely by one or a few observations. The paper examines the outgrowth from this criticism of the statistical method over the last few decades. © 2006 Springer-Verlag

The Current Impact of Title IX in the Pac-12 Conference: Who Really Benefits?

Title IX has increased opportunities for women academically and athletically. This research assessed the impact that Title IX has had in the Pac-12 Conference in the development of women’s intercollegiate athletics within the male-dominated world of sports and how female and male athletes have been impacted by Title IX implementation. Telephone surveys were conducted with 11 out of 12 Senior Women’s Administrators of universities in the Pac-12 conference. The survey examined how Title IX is currently administered and implemented at the intercollegiate level and collected more information as to how Title IX is used and interpreted across universities within the Pac-12. The research showed that Title IX increased opportunities at the Division I intercollegiate sports level in the Pac-12 conference. All universities reported that Title IX has successfully developed women’s intercollegiate sports. Women’s sports programs have flourished over the last 40 years, yet this research revealed that Title IX has also had an impact on men’s Division I intercollegiate sports in the Pac-12 conference. Three of the 11 universities cut men’s programs recently due to economics and the attempt to meet proportionality for Title IX compliance. Universities use proportionality as the primary way to meet compliance with Title IX. However, because of football programs, trying to obtain proportionality can lead to the use of roster management by some universities within the Pac-12. Furthermore, findings revealed that the implementation of Title IX and the current economic climate influence how universities interpret and apply the guidelines set forth in this legislation

Conditionally optimal weights of evidence

A weight of evidence is a calibrated statistic whose values in [0, 1] indicate the degree of agreement between the data and either of two hypothesis, one being treated as the null (H 0) and the other as the alternative (H 1). A value of zero means perfect agreement with the null, whereas a value of one means perfect agreement with the alternative. The optimality we consider is minimal mean squared error (MSE) under the alternative while keeping the MSE under the null below a fixed bound. This paper studies such statistics from a conditional point of view, in particular for location and scale models. © Springer-Verlag 2005

Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial

<p>Abstract</p> <p>Background:</p> <p>Lower respiratory tract infections like acute bronchitis, exacerbated chronic obstructive pulmonary disease and community-acquired pneumonia are often unnecessarily treated with antibiotics, mainly because of physicians' difficulties to distinguish viral from bacterial cause and to estimate disease-severity. The goal of this trial is to compare medical outcomes, use of antibiotics and hospital resources in a strategy based on enforced evidence-based guidelines versus procalcitonin guided antibiotic therapy in patients with lower respiratory tract infections.</p> <p>Methods and design:</p> <p>We describe a prospective randomized controlled non-inferiority trial with an open intervention. We aim to randomize over a fixed recruitment period of 18 months a minimal number of 1002 patients from 6 hospitals in Switzerland. Patients must be >18 years of age with a lower respiratory tract infections <28 days of duration. Patients with no informed consent, not fluent in German, a previous hospital stay within 14 days, severe immunosuppression or chronic infection, intravenous drug use or a terminal condition are excluded. Randomization to either guidelines-enforced management or procalcitonin-guided antibiotic therapy is stratified by centre and type of lower respiratory tract infections. During hospitalization, all patients are reassessed at days 3, 5, 7 and at the day of discharge. After 30 and 180 days, structured phone interviews by blinded medical students are conducted. Depending on the randomization allocation, initiation and discontinuation of antibiotics is encouraged or discouraged based on evidence-based guidelines or procalcitonin cut off ranges, respectively. The primary endpoint is the risk of combined disease-specific failure after 30 days. Secondary outcomes are antibiotic exposure, side effects from antibiotics, rate and duration of hospitalization, time to clinical stability, disease activity scores and cost effectiveness. The study hypothesis is that procalcitonin-guidance is non-inferior (i.e., at worst a 7.5% higher combined failure rate) to the management with enforced guidelines, but is associated with a reduced total antibiotic use and length of hospital stay.</p> <p>Discussion:</p> <p>Use of and prolonged exposure to antibiotics in lower respiratory tract infections is high. The proposed trial investigates whether procalcitonin-guidance may safely reduce antibiotic consumption along with reductions in hospitalization costs and antibiotic resistance. It will additionally generate insights for improved prognostic assessment of patients with lower respiratory tract infections.</p> <p>Trial registration:</p> <p>ISRCTN95122877</p

A Design of a Material Assembly in Space-Time Generating and Storing Energy

The paper introduces a theoretical background of the mechanism of electromagnetic energy and power accumulation and its focusing in narrow pulses travelling along a transmission line with material parameters variable in 1D-space and time. This mechanism may be implemented due to a special material geometry- a distribution of two different dielectrics in a spatio-temporal checkerboard. We concentrate on the practically reasonable means to bring this mechanism into action in a device that may work both as energy generator and energy storage. The basic ideas discussed below appear to be fairly general; we have chosen their electromagnetic implementation as an excellent framework for the entire concept

The rapid rotation and complex magnetic field geometry of Vega

The recent discovery of a weak surface magnetic field on the normal intermediate-mass star Vega raises the question of the origin of this magnetism in a class of stars that was not known to host magnetic fields. We aim to confirm the field detection and provide additional observational constraints about the field characteristics, by modelling the magnetic geometry of the star and by investigating the seasonal variability of the reconstructed field. We analyse a total of 799 circularly-polarized spectra collected with the NARVAL and ESPaDOnS spectropolarimeters during 2008 and 2009. We employ a cross-correlation procedure to compute, from each spectrum, a mean polarized line profile with a signal-to-noise ratio of about 20,000. The technique of Zeeman-Doppler Imaging is then used to determine the rotation period of the star and reconstruct the large-scale magnetic geometry of Vega at two different epochs. We confirm the detection of circularly polarized signatures in the mean line profiles. The amplitude of the signatures is larger when spectral lines of higher magnetic sensitivity are selected for the analysis, as expected for a signal of magnetic origin. The short-term evolution of polarized signatures is consistent with a rotational period of 0.732 \pm 0.008 d. The reconstructed magnetic topology unveils a magnetic region of radial field orientation, closely concentrated around the rotation pole. This polar feature is accompanied by a small number of magnetic patches at lower latitudes. No significant variability in the field structure is observed over a time span of one year. The repeated observation of a weak photospheric magnetic field on Vega suggests that a previously unknown type of magnetic stars exists in the intermediate-mass domain. Vega may well be the first confirmed member of a much larger, as yet unexplored, class of weakly-magnetic stars.Comment: Accepted by Astronomy & Astrophysics. Abstract shortened to respect the arXiv limit of 1920 character