Community and Clinical Epidemiology of Borderline Personality Disorder

Several studies of the prevalence of Borderline Personality Disorder (BPD) in community and clinical settings have been carried out to date. Although results vary according to sampling method and assessment method, median point prevalence of BPD is roughly 1%, with higher or lower rates in certain community subpopulations. In clinical settings, BPD prevalence is around 10-12% in outpatient psychiatric clinics and 20-22% among inpatient clinics. Further research is needed to identify the prevalence and correlates of BPD in other clinical settings (e.g., primary care) and to investigate the impact of demographic variables on BPD prevalence

Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells.

Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies. These stem-like tumor cells can persist following conventional cytoreductive therapies, such as chemotherapy and radiotherapy, thereby repopulating the tumor and seeding relapse and/or metastasis. We have previously shown that natural killer (NK) cells preferentially target stem-like tumor cells via non- major histocompatibility complex (MHC) restricted mechanisms. Here, we demonstrated that the proteasome inhibitor, bortezomib, augments NK cell targeting of stem cell-like tumor cells against multiple solid human tumor-derived cancer lines and primary tissue samples. Mechanistically, this was mediated by the upregulation of cell surface NK ligands MHC class I chain-related protein A and B (MICA and MICB) on aldehyde dehydrogenases (ALDH)-positive CSCs. The increased expression of MICA and MICB on CSC targets thereby enhanced NK cell mediated killing in vitro and ex vivo from both human primary tumor and patient-derived xenograft samples. In vivo, the combination of bortezomib and allogeneic NK cell adoptive transfer in immunodeficient mice led to increased elimination of CSCs as well as tumor growth delay of orthotopic glioblastoma tumors. Taken together, our data support the combination bortezomib and NK transfer as a strategy for both CSC targeting and potentially improved outcomes in clinical cancer patients

Suitability of single-pass backpack electrofishing to estimate fish abundance and describe assemblage structure in prairie streams

Electrofishing is commonly used by fisheries professionals to assess fish assemblage structure and species abundance in streams. Accurate estimates of fish abundance and, consequently assemblage metrics, are typically generated with mark-recapture or maximum-likelihood depletion techniques, but doing so requires considerable sampling effort. Less intensive sampling approaches may be beneficial to fisheries managers, particularly in cases where frequent sampling of many streams is preferred. We used regression and Spearman rank-order correlation analyses to compare species catch rates and the assemblage metrics generated from single-pass electrofishing samples with multiple-pass depletion abundance estimates in Nebraska streams. We examined the influence of instream habitat features on the regression residuals to further examine the effectiveness of single-pass electrofishing. Our results suggest that single-pass electrofishing is suitable for wadeable prairie streams with relatively little habitat diversity. With few exceptions, fish species were detected and captured in similar quantities regardless of electrofishing effort, suggesting that single-pass sampling can be used to quickly assess species occurrence and relative abundance. The single- and multiple-pass electrofishing methods generated slightly different values for each assemblage metric; however, these values were not significantly different. Abundance was over- or underestimated in areas where certain species were congregated (e.g., overhanging vegetation: Red Shiner Cyprinella lutrensis, Bigmouth Shiner Notropis dorsalis, large substrates: Stonecat Noturus flavus, and darters) or difficult to sample (e.g., woody debris: Largemouth Bass Micropterus salmoides and Western Mosquitofish Gambusia affinis) using only one electrofishing pass. Single-pass electrofishing offers a reliable alternative to the more intensive multiple-pass depletion techniques; however, caution should be applied in difficult to sample areas with unique habitats

Improving accuracy of total knee component cementation: description of a simple technique

<p>Abstract</p> <p>Background</p> <p>Total knee arthroplasty represents a common orthopedic surgical procedure. Achieving proper alignment of its components with the predrilled patellar and tibial peg holes prior to polymerization of the bone cement can be challenging.</p> <p>Technique</p> <p>After establishing the femoral, patellar and tibial bone cuts, the cancellous bone around the tibial keel, as well as the peg holes for the patella and femoral components are marked with methylene blue using a cotton swab stick. If bone cement is then placed onto the cut and marked bone edges, the methylene blue leaches through the bone cement and clearly outlines the tibial keel and predrilled femoral and patellar peg holes. This allows excellent visualization of the bone preparations for each component, ensuring safe and prompt positioning of TKA components while minimizing intraoperative difficulties with component alignment while the cement hardens.</p> <p>Conclusion</p> <p>The presented technical note helps to improve the accuracy and ease of insertion when the components of total knee arthroplasty are impacted to their final position.</p

Starting to Unpick the Unique Air–Fuel Mixing Dynamics in the Recuperated Split Cycle Engine

In this work air fuel mixing and combustion dynamics in the recuperated split cycle engine (RSCE) are investigated through new theoretical analysis and complementary optical experiments of the flow field. First, a brief introduction to the basic working principles of the RSCE cycle will be presented, followed by recent test bed results relevant to pressure traces and soot emissions. These results prompted fundamental questioning of the air-fuel mixing and combustion dynamics taking place. Hypotheses of the mixing process are then presented, with differences to that of a conventional Diesel engine highlighted. Moreover, the links of the reduced emissions, air transfer processes and enhanced atomisation are explored. Initial experimental results and Schlieren images of the air flow through the poppet valves in a flow rig are reported. The Schlieren images display shockwave and Mach disk phenomena. Demonstrating supersonic air flow in the chamber is consistent with complementary CFD work. The results from the initial experiment alone are inconclusive to suggest which of the three suggested mixing mechanism hypotheses are dominating the air–fuel dynamics in the RSCE. However, one major conclusion of this work is the proof for the presence of shockwave phenomena which are atypical of conventional engines

Organic moderator-coolant in-pile irradiation loop for the MIT nuclear reactor : October 1, 1958 to October 1, 1959

Includes bibliographical references (leaf 34)First annual report; to October 1, 1958 to October 1, 1959Work performed under contract with Atomics International of North American Aviation, Inc. N9-S-514Division of Sponsored Research Project no. 8091Atomic Energy Commission contract no. AT(10-1)-106

Catalyzing Rebellion: An Introduction to the Mobilization in Miniature Project

http://deepblue.lib.umich.edu/bitstream/2027.42/50913/1/138.pd