3,118 research outputs found
Lifting representations of finite reductive groups: a character relation
Given a connected reductive group over a finite field , and a
semisimple -automorphism of of finite order, let
denote the connected part of the group of -fixed points. Then
there exists a lifting from packets of representations of to packets for
. In the case of Deligne-Lusztig representations, we show that
this lifting satisfies a character relation analogous to that of Shintani.Comment: Minor errors corrected, proofs streamlined. Main result slightly
generalized, restated to emphasize analogy with stabilit
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence.
BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S. aureus Newman for susceptibility to cathelicidin antimicrobial peptide, we discovered BlaI as a novel cathelicidin resistance factor. Additionally, through integrational mutagenesis in S. aureus Newman and MRSA Sanger 252 strains, we confirmed the role of BlaI in resistance to human and murine cathelidicin and showed that it contributes to virulence in human whole blood and murine infection models. We further demonstrated that BlaI could be a target for innate immune-based antimicrobial therapies; by removing BlaI through subinhibitory concentrations of 6-aminopenicillanic acid, we were able to sensitize S. aureus to LL-37 killing
CTQ 414: A New Gravitational Lens
We report the discovery and ground based observations of the new
gravitational lens CTQ 414. The source quasar lies at a redshift of z = 1.29
with a B magnitude of 17.6. Ground based optical imaging reveals two point
sources separated by 1.2 arcsec with a magnitude difference of roughly 1 mag.
Subtraction of two stellar point spread functions from images obtained in
subarcsecond seeing consistently leaves behind a faint, residual object. Fits
for two point sources plus an extended object places the fainter object
collinear with the two brighter components. Subsequent HST/NICMOS observations
have confirmed the identification of the fainter object as the lensing galaxy.
VLA observations at 8.46 GHz reveal that all components of the lensing system
are radio quiet down to the 0.2 mJy flux level.Comment: Latex, 18 pages including 2 ps figures; accepted for publication in
A
Si microwire-array solar cells
Si microwire-array solar cells with Air Mass 1.5 Global conversion efficiencies of up to 7.9% have been fabricated using an active volume of Si equivalent to a 4 μm thick Si wafer. These solar cells exhibited open-circuit voltages of 500 mV, short-circuit current densities (J_(sc)) of up to 24 mA cm^(-2), and fill factors >65% and employed Al_2O_3 dielectric particles that scattered light incident in the space between the wires, a Ag back reflector that prevented the escape of incident illumination from the back surface of the solar cell, and an a-SiN_x:H passivation/anti-reflection layer. Wire-array solar cells without some or all of these design features were also fabricated to demonstrate the importance of the light-trapping elements in achieving a high J_(sc). Scanning photocurrent microscopy images of the microwire-array solar cells revealed that the higher J_(sc) of the most advanced cell design resulted from an increased absorption of light incident in the space between the wires. Spectral response measurements further revealed that solar cells with light-trapping elements exhibited improved red and infrared response, as compared to solar cells without light-trapping elements
The Demands of a Women\u27s College Soccer Season
The purpose of this study was to use GPS, accelerometers, and session rating of perceived exertion (sRPE) to examine the demands of a Division II women’s soccer team. Data was collected on 25 collegiate Division II women’s soccer players over an entire regular season (17 matches and 24 practices). ZephyrTM BioHarnesses (BHs) were used to collect tri-axial acceleration information and GPS derived variables for all matches and practices. Acceleration data was used to calculate Impulse Load, a measure of mechanical load that includes only locomotor related accelerations. GPS was used to quantify total distance and distance in six speed zones. Internal Training Loads were assessed via sRPE. Mean Impulse Load, total distance, and sRPE during match play was 20,120 ± 8609 N·s, 5.48 ± 2.35 km, and 892.50 ± 358.50, respectively. Mean Impulse Load, total distance, and sRPE during practice was 12,410 ± 4067 N·s, 2.95 ± 0.95 km, and 143.30 ± 123.50, respectively. Several very large to nearly perfect correlations were found between Impulse Load and total distance (r = 0.95; p < 0.001), Impulse Load and sRPE (r = 0.84; p < 0.001), and total distance and sRPE (r = 0.82; p < 0.001). This study details the mechanical demands of Division II women’s soccer match play. This study also demonstrates that Impulse Load is a good indicator of total distance
PMN J1632-0033: A new gravitationally lensed quasar
We report the discovery of a gravitationally lensed quasar resulting from our
survey for lenses in the southern sky. Radio images of PMN J1632-0033 with the
VLA and ATCA exhibit two compact, flat-spectrum components with separation
1.47" and flux density ratio 13.2. Images with the HST reveal the optical
counterparts to the radio components and also the lens galaxy. An optical
spectrum of the bright component, obtained with the first Magellan telescope,
reveals quasar emission lines at redshift 3.42. Deeper radio images with MERLIN
and the VLBA reveal a faint third radio component located near the center of
the lens galaxy, which is either a third image of the background quasar or
faint emission from the lens galaxy.Comment: 21 pp., including 4 figures; thoroughly revised in light of new
MERLIN/HST data; accepted for publication in A
Securing the legacy of TESS through the care and maintenance of TESS planet ephemerides
Much of the science from the exoplanets detected by the TESS mission relies
on precisely predicted transit times that are needed for many follow-up
characterization studies. We investigate ephemeris deterioration for simulated
TESS planets and find that the ephemerides of 81% of those will have expired
(i.e. 1 mid-transit time uncertainties greater than 30 minutes) one
year after their TESS observations. We verify these results using a sample of
TESS planet candidates as well. In particular, of the simulated planets that
would be recommended as JWST targets by Kempton et al. (2018), 80% will
have mid-transit time uncertainties 30 minutes by the earliest time JWST
would observe them. This rapid deterioration is driven primarily by the
relatively short time baseline of TESS observations. We describe strategies for
maintaining TESS ephemerides fresh through follow-up transit observations. We
find that the longer the baseline between the TESS and the follow-up
observations, the longer the ephemerides stay fresh, and that 51% of simulated
primary mission TESS planets will require space-based observations. The
recently-approved extension to the TESS mission will rescue the ephemerides of
most (though not all) primary mission planets, but the benefits of these new
observations can only be reaped two years after the primary mission
observations. Moreover, the ephemerides of most primary mission TESS planets
(as well as those newly discovered during the extended mission) will again have
expired by the time future facilities such as the ELTs, Ariel and the possible
LUVOIR/OST missions come online, unless maintenance follow-up observations are
obtained.Comment: 16 pages, 10 figures, accepted to AJ; main changes are cross-checking
results against the sample of real TOIs, and addressing the impact of the
TESS extended missio
Relating the metatranscriptome and metagenome of the human gut
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized. This knowledge gap is in part because of the difficulty of acquiring large numbers of samples amenable to functional studies of the microbiota. We conducted what is, to our knowledge, one of the first human microbiome studies in a well-phenotyped prospective cohort incorporating taxonomic, metagenomic, and metatranscriptomic profiling at multiple body sites using self-collected samples. Stool and saliva were provided by eight healthy subjects, with the former preserved by three different methods (freezing, ethanol, and RNAlater) to validate self-collection. Within-subject microbial species, gene, and transcript abundances were highly concordant across sampling methods, with only a small fraction of transcripts (\u3c5%) displaying between-method variation. Next, we investigated relationships between the oral and gut microbial communities, identifying a subset of abundant oral microbes that routinely survive transit to the gut, but with minimal transcriptional activity there. Finally, systematic comparison of the gut metagenome and metatranscriptome revealed that a substantial fraction (41%) of microbial transcripts were not differentially regulated relative to their genomic abundances. Of the remainder, consistently underexpressed pathways included sporulation and amino acid biosynthesis, whereas up-regulated pathways included ribosome biogenesis and methanogenesis. Across subjects, metatranscriptional profiles were significantly more individualized than DNA-level functional profiles, but less variable than microbial composition, indicative of subject-specific whole-community regulation. The results thus detail relationships between community genomic potential and gene expression in the gut, and establish the feasibility of metatranscriptomic investigations in subject-collected and shipped samples
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