Debating the 'Querelle des Femmes': literature, theatre and education

Ministerio de Economia y CompetitividadJunta de Castilla y Leo

Building and Collapse of the Cadomian Orogen: A Plate-Scale Model Based on Structural Data From the SW Iberian Massif

The Cadomian Orogeny produced a subduction-related orogen along the periphery of Gondwana and configured the pre-Variscan basement of the Iberian Massif. The architecture of the Cadomian Orogen requires detailed structural analysis for reconstruction because of severe tectonic reworking during the Paleozoic (Variscan cycle). Tectonometamorphic analysis and data compilation in SW Iberia (La Serena Massif, Spain) have allowed the identification of three Cadomian deformation phases and further constrained the global architecture and large-scale processes that contributed to the Ediacaran building and early Paleozoic dismantling of the Cadomian Orogen. The first phase (DC1, prior to 573 Ma) favored tabular morphology in plutons that intruded during the building of a continental arc. The second phase (DC2, 573–535 Ma) produced an upright folding and contributed to further crustal thickening. The third phase of deformation (DC3, ranging between ∼535 and ∼480 Ma) resulted in an orogen-parallel dome with oblique extensional flow. DC1 represents the crustal growth and thickening stage. DC2 is synchronous with a period of crustal thickening that affected most of the Gondwanan periphery, from the most external sections (Cadomian fore-arc) to the inner ones (Cadomian back-arc). We explain DC2 as a consequence of flat subduction, which was followed by a period dominated by crustal extension (DC3) upon roll-back of the lower plate. The Ediacaran construction of the Cadomian Orogen (DC1 and DC2) requires ongoing subduction beneath Gondwana s.l., whereas its dismantlement during the Early Paleozoic is compatible with oblique, sinistral convergence.Projects PID2020-112489GB-C21 and PID2020-112489GB-C22, funded by MCIN/AEI/10.13039/50110001103

Phthalate exposure and the metabolic syndrome: A systematic review and meta-analysis

Phthalates are chemicals widely used in plastic-based consumer products, and human exposure is universal. They are classified as endocrine disruptors, and specific phthalate metabolites have been associated with an increased risk of cardiometabolic diseases. The aim of this study was to assess the association between phthalate exposure and the metabolic syndrome in the general population. A comprehensive literature search was performed in four databases (Web of Science, Medline, PubMed, and Scopus). We included all the observational studies that evaluate the association between phthalate metabolites and the metabolic syndrome available until January 31st, 2023. Pooled Odds Ratios (OR) and their 95% confidence intervals were calculated by using the inversevariance weighted method. Nine cross-sectional studies and 25,365 participants aged from 12 to 80 were included. Comparing extreme categories of phthalate exposure, the pooled ORs for the metabolic syndrome were: 1.08 (95% CI, 1.02–1.16, I 2 = 28%) for low molecular weight phthalates, and 1.11 (95% CI, 1.07–1.16, I 2 = 7%) for high molecular weight phthalates. For individual phthalate metabolites, the pooled ORs that achieved statistical significance were: 1.13 (95% CI, 1.00–1.27, I 2 = 24%) for MiBP; 1.89 (95% CI, 1.17–3.07, I 2 = 15%) for MMP in men; 1.12 (95% CI, 1.00–1.25, I 2 = 22%) for MCOP; 1.09 (95% CI, 0.99–1.20, I 2 = 0%) for MCPP; 1.16 (95% CI, 1.05–1.28, I 2 = 6%) for MBzP; and 1.16 (95% CI, 1.09–1.24, I 2 = 14%) for DEHP (including ΣDEHP and its metabolites). In conclusion, both low molecular weight and high molecular weight phthalates were associated with an 8 and 11% higher prevalence of the MetS, respectively. The exposure to six specific phthalate metabolites was associated with a higher prevalence of the MetSData collection was funded by the following grants: FIS PI17/1709, PI20/144 (State Secretary of R + D and FEDER/FSE), and the CIBERESP, Instituto de Salud Carlos III. Madrid, Spain. MM has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement [(No 801342 (Tecniospring INDUSTRY)] and the Government of Catalonia’s Agency for Business Competitiveness (ACCIO) ´ (TECSPR19-1-0022

Influence of Hyrax screw position on dental movement and cortical bone : a study of finite elements

Rapid maxillary expansion (RME) has effects on the dental and periodontal structures of the parts involved, which vary according to the design and position of the expansion screw. The purpose of the study was to determine the optimal three-dimensional position of the Hyrax screw to obtain precise control of the dental movement and effect on the bone cortex using the finite element method (FEM). RME was performed from the patient whom two Cone-Beam computerized tomography scans (CBCT) were obtained: T1 before expansion, and T2 three months after stabilization of RME. The FEM model was designed with T1 and of Hyrax photographs. FEM was obtained by comparing the simulation, T2, and clinical results. Three sagittal screw positions (anterior-middle-posterior) and vertical (upper-medium-low) were evaluated. A coronal- buccal displacement of premolars and first molars was found which decreased in the occlusal-apical direction, presenting different types of dental movement in the screw positions; besides, a tendency of translational movement in the posterior-high location was observed. In the posterior-high position a higher concentration of efforts and homogeneous deformations in the periodontal ligament and vestibular cortex of the cervical area of first molars, first and second premolars were observed, with variations according to the screw position and the distribution of stresses. The ideal location of the expansion screw for controlling dental movement and periodontal side effects was the high-posterior position

Simulador gastrointestinal dinámico (simgi®): Una herramienta potencialmente útil en nutrición clínica

The human gastrointestinal tract harbours the most complex and abundant community of the human body, the colon being where the highest microbial concentration is found (10 12 cell/g). The intestinal microbiota exerts metabolic, trophic and protective functions which are important in the maintenance of the host health. Over recent decades, numerous studies have attempted to provide scientific evidence about the environmental factors that can impact on human health through the modulation of the intestinal microbiota composition. However, this approach is changing, and a new focus on assessing changes at functional level is being developed. If we apply this dual approach to the role played by the diet, it is obvious the need of dynamic gastrointestinal simulation models such as simgi®, that allow to evaluate the transformations undergone by food and/or food ingredients during their transit through the gastrointestinal tract, as well as to determine potential changes in the composition and functionality of the intestinal microbiota after food ingestion. So far the studies using the simgi® have confirmed its potential applications in the area of food as a prior step to its application in clinical nutrition to prevent and/or treat diseases associated with intestinal dysbiosis and metabolic disorders. Likewise, this review includes feasible perspectives of the use of simgi® in clinical research concerning to diseases related to the intestinal microbiota.Dentro de la microbiota humana, el tracto gastrointestinal alberga el ecosistema más complejo y abundante del cuerpo humano, siendo el colon donde se encuentra la concentración más alta de microorganismos (1012 cel/g). La microbiota intestinal desempeñaa funciones metabólicas, tróficas y de protección que son de gran importancia para el hospedador. Durante las últimas décadas, son numerosos los estudios que han tratado de aportar evidencias científicas acerca de los factores que, a través de cambios en la composición de la microbiota intestinal, influyen en la salud humana. Sin embargo, esta aproximación está cambiando, y son cada vez más los expertos que apuestan por evaluar cambios a nivel de funcionalidad de la microbiota. Si aplicamos este enfoque dual al papel desempeñado por la dieta, resulta obvia la necesidad de disponer de modelos dinámicos de simulación gastrointestinal, como es el simgiR, que permitan evaluar las transformaciones que sufren los alimentos y/o ingredientes alimentarios durante el tránsito por el tracto gastrointestinal, así como para determinar los posibles cambios en la composición y funcionalidad de la microbiota intestinal derivados de la ingesta de alimentos. Los estudios llevados a cabo hasta el momento con el simgiR constatan sus potenciales aplicaciones en el área de los alimentos como paso previo a su aplicación en nutrición clínica, para prevenir y/o tratar enfermedades asociadas a disbiosis intestinal, así como trastornos metabólicos. Asimismo, esta revisión recoge posibles perspectivas de utilización del simgiR en la investigación clínica relativa a enfermedades vinculadas con disfunciones de la microbiota intestinalEste trabajo ha sido realizado gracias a la financiación del MINECO (proyecto AGL2015- 64522-C2-R) y la Comunidad de Madrid (Programa ALIBIRD-CM S2013/ABI-2728-CM). Alba Tamargo es beneficiaria de un contrato en el Programa de Garantía Juvenil-CSIC financiado gracias al Fondo Social Europeo. Irene Gil Sánchez es beneficiaria de una beca FPU del MECD (FPU14/0576

Seguimiento a graduados de la Carrera de Enfermería de la Universidad Técnica de Ambato

Seguimiento a graduados de la Carrera de Enfermería de la Universidad Técnica de Ambat

Orogenic reworking and reactivation in Central Iberia: A record of Variscan, Permian and Alpine tectonics

Interference between orogenic systems and deformation phases within them may lead to reworking and reactivation of previous structures. The eastern sector of the Spanish-Portuguese Central System holds evidence of two orogenic systems, Variscan and Alpine, plus a stage of Permian extension. We perform an integrated structural analysis to identify reworking and reactivation processes throughout the geological record. The Variscan record starts with crustal thickening (D1; E-verging overturned folds). A second phase features the intra-orogenic collapse of an overthickened crust (D2; top-to-the-SE ductile extensional shear zone), which produced intense structural reworking at the core of the shear zone and moderate reworking at its hanging wall. During subsequent strike-slip tectonics, crustal thickening parted transpressional deformation into a dextral shear zone and upright folds (D3). Variscan deformation did not reactivate previous structures, but exploited a weak rheological boundary defined by contrasted lithologies (sedimentary versus igneous rocks) to accommodate D2 shearing. Reactivation played a role afterwards: Variscan strike-slip shear zone acted as a transfer fault to accommodate Permian extension (post-orogenic collapse), and then Alpine contraction. The Permian extension record is blurred by Alpine inversion, although the trend of Alpine structures in Central Iberia, and the Spanish-Portuguese Central System, may result from Permian structural inheritance

Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma

Survival of patients with oral squamous cell carcinoma (OSCC) is generally low, with the likelihood of locoregional recurrence or disease progression (LR/DP). Knowledge of prognostic factors for survival is key to achieving an understanding and increased survival. The present study aimed to identify prognostic factors for patients with OSCC, especially the presence of DNA from human papillomavirus (HPV). Retrospective cohort study including 119 patients with OSCC treated at the National Cancer Institute in Mexico City (2009-2013). Clinical information was obtained from patient records including LR/DP. Formalin-fixed, paraffin-embedded tissues were obtained and used for detecting DNA from different types of HPV. Potential prognostic factors for Overall Survival (OS) were analyzed using the Cox proportional hazards model. After model adjustment, factors associated with longer OS were a pre-treatment platelet count above 400,000/mm3 (HR=0.09, p=0.026) and response to primary treatment (HR=0.26, p=0.001). HPV DNA was present in 23 (19.3%) of the patients and importantly, type 16 found in 19 of them. Although survival of HPV-positive patients was longer, difference was not significant. However, among patients with LR/DP, HPV positivity was significantly associated with increased survival (HR=0.23, p=0.034). Importantly, survival was significantly different for HPV-positive patients with LR/DP > 6 months (HR=0.20, p=0.002), had higher absolute lymphocyte count at start of treatment (HR=0.50, p=0.028) or had local rescue treatment (HR=0.24, p=0.019). Although HPV positivity was not associated with a longer OS of OSCC patients, a better prognosis was significantly associated with HPV positivity and recurring or progressing disease, particularly with HPV type 16

Catálogo de variedades de yuca, Cauca - Colombia

El presente catálogo de variedades de yuca representa la diversidad del cultivo en el departamento del Cauca, Colombia. En él, se han resumido las 28 variedades criollas y mejoradas como una guía de las mejores variedades disponibles en la región; para suplir las demandas de las rallanderias por almidón panificable. Cada variedad tiene descritas las características morfológicas, agronómicas, área y rendimiento reportado por agricultores y adicionalmente un código genético basado en marcadores moleculares tipo SNP