El autorreporte de funcionamiento ejecutivo media la asociación entre la obesidad y suicidalidad reciente: una encuesta en línea

The study intended to test for mediation effects of self-reported executive function (EF) between obesity and past 30-days suicide-behaviors. A web-based survey was conducted diffusing it to the general Mexican population via social media. Suicide was evaluated with the corresponding module of the Mini International Neuropsychiatric Interview, and a short form of the Behavioral Rating Inventory of Executive Functions-Adults for EF. Body mass index was computed from the self-reported height/weight. Causal-mediation analyses was performed for each of the suicide variables, including obesity and EF as predictor and mediator, respectively. Data from 1234 participants was analyzed, 274 classified as having obesity. EF partially mediated 20% of the effect of obesity on suicide behaviors. As the BMI progresses to the categories of obesity, EF deficiencies may be insufficient to cope optimally with the emotional and social stressors associated to obesity, thus leading to more frequent or intense suicide ideation, planning or attemptsEl presente estudio tuvo como objetivo evaluar el efecto de mediación del autorreporte de funcio-namiento ejecutivo (FE) entre la obesidad y la conducta suicida en los 30 días previos. Se condujo una encuesta a través de la web, la cual se difundió a la población general de México a través de redes sociales. El suicidio fue evaluado con el módulo correspondiente de la Mini Entrevista Neuropsiquiá-trica Internacional, y el FE con una versión breve de la Evaluación Conductual de la Función Ejecutiva para adultos. El índice de masa corporal se calculó del autorreporte de talla y peso. Se realizó análisis de mediación causal para cada una de las variables de suicidio, incluyendo la obesidad y el FE como predictores respectivamente. Se analizaron los datos de 1234 participantes, de los cuales 274 fueron clasificados dentro del grupo con obesidad. El FE mediaba aproximadamente el 20% del efecto de la obesidad en la conducta suicida. Los resultados sugieren que conforme el índice de Masa Corporal incrementa hacía la obesidad, el FE puede ser insuficiente para poder afrontar de forma óptima con los estresores emocionales y sociales asociados al incremento del peso, lo cual, trae como consecuencia una ideación, planeación intentos de suicidio más frecuentes o intenso

Investigation of the preparation and reactivity of metal-organic frameworks of cerium and pyridine-2,4,6-tricarboxylate

The synthesis of three coordination polymers of cerium(III) and the ligand pyridine-2,4,6-tricarboxylate (PTC) is reported. Two of the materials crystallise under hydrothermal conditions at 180 °C, with [Ce(PTC)(H O) ]·1.5H O, (1), being formed on extended periods of reaction time, 3 days or longer, and Ce(PTC)(H O) , (2), crystallising after 1 day. Both phases contain Ce(III) but are prepared using the Ce(IV) salt Ce(SO ) ·4H O as reagent. Under solvothermal conditions (mixed water- , -dimethylformamide (DMF)), the phase [Ce(PTC)(H O)(DMF)]·H O (3) is crystallised. The structures of the three materials are resolved by single crystal X-ray diffraction, with the phase purity of the samples determined by powder X-ray diffraction and thermogravimetric analysis. (1) is constructed from helical chains cross-linked by the PTC linkers to give a three-dimensional structure that contains clusters of water molecules in channels that are hydrogen-bonded to each other and to additional waters that are coordinated to cerium. (2) also contains nine-coordinate cerium but these are linked to give a dense framework, in which water is directly coordinated to cerium. (3) contains corner-shared nine-coordinate cerium centres, linked to give a framework in which Ce-coordinated DMF fills space. Upon heating the material (1) in air all water is irreversibly lost to give a poorly crystalline anhydrous phase Ce(PTC), as deduced from X-ray thermodiffractometry and thermogravimetric analysis. The material (1), however, is hydrothermally stable, and is also stable under oxidising conditions, where immersion in 30% H O gives no loss in crystallinity. Oxidation of around 50% of surface Ce to the +4 oxidation state is thus possible, as evidenced by X-ray photoelectron spectroscopy, which is accompanied by a colour change from yellow to orange. Photocatalytic activity of (1) is screened and the material shows effective degradation of methyl orange

LESÕES CUTÂNEAS EM RECÉM-NASCIDOS SOB CUIDADOS INTENSIVOS: REVISÃO INTEGRATIVA

The Neonatal Intensive Care Unit (NICU) is an appropriate therapeutic environment for the treatment of newborns in serious condition, which has the latest technology and diversified equipment, in addition to highly trained and specific professionals for the care of newborns. The objective is to analyze and describe the scientific evidence on the risk factors for the development of cutaneous and care to maintain the integrity of the newborn's skin in the Neonatal Intensive Care Unit (NICU). An integrative literature review was carried out, with a descriptive nature and a qualitative approach. The data search was performed through the Virtual Health Library (VHL), and its databases: BDENF, MEDLINE, LILACS and IBECS. Complete works were included, available in full, that addressed the theme: skin integrity, with an emphasis on care and practices adopted in the NICU, including risk factors and incidence of injuries, in addition to studies that were sampled by preterm NB and the term, published from 2016 to 2021, in Portuguese, English and Spanish. Works that did not present relevant theoretical foundations on the subject were excluded, as well as publications with duplicity. Through the studies, it can be concluded that several factors are associated with the appearance of skin lesions, and prematurity should be highlighted as one of the main points, considering that premature NBs have more sensitive skin, making them more susceptible to the onset of most.La Unidad de Cuidados Intensivos Neonatales (UCIN) es un entorno terapéutico adecuado para el tratamiento de recién nacidos en estado grave, que cuenta con tecnología de punta y equipamiento diversificado, además de profesionales altamente capacitados y protocolos específicos para la atención del recién nacido. El objetivo es analizar y describir la evidencia científica sobre los factores de riesgo para el desarrollo de lesiones cutáneas y cuidados para mantener la integridad de la piel del recién nacido en la Unidad de Cuidados Intensivos Neonatales (UCIN). Se realizó una revisión integradora de la literatura, con carácter descriptivo y enfoque cualitativo. La búsqueda de datos se realizó a través de la Biblioteca Virtual en Salud (BVS) y sus respectivas bases de datos: BDENF, MEDLINE, LILACS e IBECS. Se incluyeron trabajos completos, disponibles en su totalidad, que abordaron el tema: integridad de la piel, con énfasis en los cuidados y prácticas adoptadas en la UCIN, incluyendo factores de riesgo e incidencia de lesiones, así como estudios cuya muestra estuvo constituida por RN prematuros y posteriores, publicado de 2016 a 2021, en portugués, inglés y español. Se excluyeron trabajos que no presentaran fundamentos teóricos relevantes sobre el tema, así como publicaciones con duplicidad. A través de los estudios se puede concluir que varios factores se asocian con la aparición de lesiones cutáneas, destacándose la prematuridad como uno de los principales, considerando que los RN prematuros tienen piel más sensible, siendo más susceptibles a la aparición de lesiones.A Unidade de Terapia Intensiva Neonatal (UTIN) é um ambiente terapêutico apropriado para o tratamento do RN em estado grave, que conta com tecnologia de ponta e equipamentos diversificados, além de profissionais altamente capacitados e protocolos específicos para a assistência ao RN. Objetiva-se analisar e descrever as evidências científicas sobre os fatores de risco para o desenvolvimento de lesões cutâneas e os cuidados para manutenção da integridade da pele do recém-nascido em Unidade de Terapia Intensiva Neonatal (UTIN). Foi realizada uma revisão integrativa da literatura, de natureza descritiva e abordagem qualitativa. A busca de dados foi realizada por meio da Biblioteca Virtual em Saúde (BVS), e suas respectivas bases de dados: BDENF, MEDLINE, LILACS e IBECS. Foram incluídos trabalhos completos, disponíveis na íntegra, que abordassem o tema: integridade da pele, com ênfase em cuidados e práticas adotadas na UTI neonatal, incluindo fatores de risco e incidência de lesões, além de estudos cuja amostra foi composta por RN pré-termo e a termo, publicados no período de 2016 a 2021, nos idiomas português, inglês e espanhol. Excluiu-se trabalhos que não apresentavam fundamentação teórica relevante sobre a temática, além de publicações com duplicidade. Por meio dos estudos, pode-se concluir que diversos fatores estão associados ao aparecimento das lesões cutâneas, devendo-se destacar a prematuridade como um dos principais pontos, tendo em vista que RN prematuro possui uma pele mais sensível, estando mais suscetível ao aparecimento de lesões

Aureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin

<div><p>The influenza virus causes acute respiratory infections, leading to high morbidity and mortality in groups of patients at higher risk. Antiviral drugs represent the first line of defense against influenza, both for seasonal infections and pandemic outbreaks. Two main classes of drugs against influenza are in clinical use: M2-channel blockers and neuraminidase inhibitors. Nevertheless, because influenza strains that are resistant to these antivirals have been described, the search for novel compounds with different mechanisms of action is necessary. Here, we investigated the anti-influenza activity of a fungi-derived natural product, aureonitol. This compound inhibited influenza A and B virus replication. This compound was more effective against influenza A(H3N2), with an EC₅₀ of 100 nM. Aureonitol cytoxicity was also very low, with a CC₅₀ value of 1426 μM. Aureonitol inhibited influenza hemagglutination and, consequently, significantly impaired virus adsorption. Molecular modeling studies revealed that aureonitol docked in the sialic acid binding site of hemagglutinin, forming hydrogen bonds with highly conserved residues. Altogether, our results indicate that the chemical structure of aureonitol is promising for future anti-influenza drug design.</p></div

Effects of aureonitol on influenza attachment/entry.

<p>(A) Virus particles were pre-treated for 1 h at room temperature. This mixture was diluted and incubated with MDCK cells for 1 h at 37°C (black bar). MDCK cells were pre-treated for 1 h at 37°C and washed. The cells were then exposed to pseudotyped influenza for 1 h at 4°C, washed again, and the temperature was shifted to 37°C (white bar). MDCK cells were exposed to the indicated influenza pseudotyped virus and treated for 1 h at 4°C. The cells were then washed with PBS and the temperature was raised to 37°C (gray bars). (B) Using the last treatment approach, pseudotyped influenza viruses representative of the indicated strains were used, and different concentrations of aureonitol were evaluated. (C) MDCKs (2 x 10⁶ cells) were infected with influenza at a MOI of 1.0 for 1 h at 4°C in the presence of the indicated treatments. After that, the cells were washed, lysed with buffer A and centrifuged (10 min. at 1000 x <i>g</i>). RNA was extract from the supernatant fraction, and quantitative RT-PCR to detect influenza A genome was performed. In panels A and B, luciferase activity was measured with a commercial kit (Promega). In panel C, the standard curve method was employed using a plasmid containing the influenza M1 gene as a reference. The experiments were performed 4 times. *<i>P <</i> 0.01.</p

Antiviral activity of Aureonitol against influenza A and B viruses.

<p>*Laboratory-adapted influenza A(H3N2).</p><p>Antiviral activity of Aureonitol against influenza A and B viruses.</p