Time course of lung injury in rat acute pancreatitis

Objective: Lung injury is asevere complication of acute pancreatitis that increases the mortality rate of the disease. The pathophysiology of acute pancreatitis has been studied in several experimental models, but the kinetics of pulmonary complications in relation to the pancreatic disease is not completely understood. We then studied the severity of acute pancreatitis-associated lung injury over 18 h in rats that had taurocholic acid injection in the pancreatic duct and determined whether blood collected from rats with pancreatitis is toxic enough to induce injury in normal lungs. Design and setting: Prospective, randomized, and controlled animal study in an animal research laboratory in auniversity hospital. Interventions: We isolated lungs from rats with acute pancreatitis 2, 6, and 18 h after taurocholic acid injection in the biliopancreatic duct and perfused them with blood collected from the same rats. Additionally, blood collected from rats with acute pancreatitis (time-points: 2 and 6 h) was perfused in normal lungs. Measurements and results: Taurocholic acid injection induced asevere pancreatic injury that started as early as 2 h after the injection and persisted without recovery over the 18-h study period. In contrast, the pulmonary injury was transient, appearing at the 6-h time point with recovery by the end of the study. Pulmonary injury was moderate and evidenced mostly during lung reperfusion. Interestingly, blood collected at the 2-h time point in pancreatic rats induced pulmonary injury in normal lungs while blood collected at the 6-h time-point was not toxic. Conclusions: While pancreatic injury persists over the full experimental period, pulmonary injury is transient in our experimental model. The recovery of lung injury by 18 h might be explained by adecrease in the overall toxicity of pancreatic blood over tim

Unusual Masses of the Pancreas to Be Aware of

This paper aims at emphasizing the difficulty in assessing preoperatively the diagnosis of solid masses of the pancreas whatever the initial clinical presentation may be. We illustrate our purpose describing consecutive cases of pancreatic masses of the pancreas we recently had and who were followed according to the internal guidelines of investigation of our referral hospital. Whereas malignant tumors of the pancreas represent the vast majority of solid tumors of the pancreas, other diagnoses must be evoked. We report three cases of pancreatic solid masses that were explored by endoscopic ultrasonography coupled with fine needle aspiration, a method universally considered to be both reliable and accurate but which failed to assess definitive diagnosis due to both cytological pitfalls and sampling error

Predictability of the Evolution of the Soil Structure using Water Flow Modeling for a Constructed Technosol

International audienceThis paper focuses on the rela on between the structure of a constructed Technosol and its hydraulic characteris cs during its early pedogenesis. The method is based on a 3-yr comparison of, on one hand, experimental measurements from an in situ gravita on lysimeter and, on the other hand, a modeling approach with HYDRUS-1D. The change of water fl ow pa erns with me was described. It was consistent with previous results for constructed Technosol aggrega on. Apart from seasonal varia ons, the specifi city of the hydraulic func oning of the constructed Technosol was shown to be due to the nature of its technogenic parent materials. The in situ evolu on of the hydrodynamics has been established and partly linked to external factors (climate, vegeta on). The direct modeling and the op miza on of the parameters over fi rst a 3-yr period and then three 9-mo periods accurately represented global water fl ow trends at the pedon scale. However it failed to simulate precisely the main events, such as massive leachate ou low. An evolu on with me of some of the hydraulic proper es was shown, expressing the structuring of the soil. The existence of two dis nct me-scales (slow and steady/fast and cyclic) of the evolu on of hydraulic parameters was then formulated as a new hypothesis. Abbrevia ons: Hz, horizon; TDR, me domain refl ectometry

Uso da micropedologia na descrição de processos pedogenéticos em Tecnossolos

International audienceTechnosols are characterized by the presence of mineral and organic parent materials of technogenic origin (e.g. agricultural or urban wastes, industrial by-products, building materials, transported natural materials). In view of the continual increase of such man-made soils, there is a true need of understanding their functioning and evolution. Micropedology, i.e. morphological and analytical characterization of pedofeatures on soil sections, appears as a relevant approach to take into account the diversity and the specificity of Technosols in the knowledge of their pedogenetic processes. Micropedology was investigated at microscopic and submicroscopic scale on four Technosols. Therefore, it determined specific features of anthropogenic constituents allowing in situ monitoring until the early stages of Technosol pedogenesis. Organic matter dynamics, soil porosity evolution, impact of faunal activity or hydric conditions on Technosol structure were investigated. Moreover, as Technosol components and deposition modes are diverse, one can expect numerous interfaces. In that way, micropedology appeared particularly well adapted to study these local interfaces as sites of favoured pedogenesis. Supplemented with overall physico-chemical soil analyses, characterization of Technosol pedogenic features using micropedology improves the understanding of their functioning and evolution. In addition, according to the environmental context, such data also give useful information for the Technosol management.RESUMEN Los Tecnosoles se caracterizan por la presencia de materiales orgánicos y minerales de origen tecnogenético (p.ej. residuos agrícolas o urbanos, subproductos industriales, materiales de construcción, materiales naturales transportados, etc.). Dado el aumento continuo de estos tipos de suelos antrópicos, es necesario comprender su funcionamiento y evolución. La micropedología, definida como la caracterización morfológica y analítica de microestructuras de láminas de suelo, es una herramienta estándar para el estudio de los mismos. La micropedología ofrece un enfoque relevante para el conocimiento de los procesos edafogenéticos de los Tecnosoles, ya que permite considerar la diversidad y la especificidad de los mismos. Cuatro tipos de Tecnosoles fueron investigados mediante técnicas de micropedología a escala fotónica y de ultraestructura. Así, fue posible determinar las características de los constituyentes antropogénicos y realizar un seguimiento in situ hasta las fases tempranas de la edafogénesis de estos Tecnosoles. Se investigaron procesos como la dinámica de la materia orgánica, la evolución de la porosidad y el impacto de la actividad de la fauna o de las condiciones hídricas en la estructura de los Tecnosoles. Además, ya que los Tecnosoles son muy diversos tanto en sus componentes como en el modo en que estos componentes se organizan, es esperable que existan numerosas interfaces entre horizontes de suelo. De este modo, la micropedología se adapta muy bien al estudio de estas interfaces locales donde se dan procesos edafogenéticos. La caracterización micropedológica de las microestructuras de los Tecnosoles, complementada con análisis físico-químicos generales, incrementa de modo sustancial la comprensió

Nickel hyperaccumulation mechanisms: a review on the current state of knowledge

Background: Hyperaccumulator plants are unusual plants that accumulate particular metals or metalloids, such as nickel, zinc, cadmium and arsenic, in their living tissues to concentrations that are hundreds to thousands of times greater than what is normal for most plants. The hyperaccumulation phenomenon is rare (exhibited by less than 0.2% of all angiosperms), with most of the ~500 hyperaccumulator species known globally for nickel. Scope: This review highlights the contemporary understanding of nickel hyperaccumulation processes, which include root uptake and sequestration, xylem loading and transport, leaf compartmentation and phloem translocation processes. Conclusions: Hyperaccumulator plants have evolved highly efficient physiological mechanisms for taking up nickel in their roots followed by rapid translocation and sequestration into the aerial shoots. The uptake of nickel is mainly involved with low affinity transport systems, presumably from the ZIP family. The presence of high concentrations of histidine prevents nickel sequestration in roots. Nickel is efficiently loaded into the xylem, where it mainly presents as Ni. The leaf is the main storage organ, which sequestrates nickel in non-active sites, e.g. vacuoles and apoplast. Recent studies show that phloem translocates high levels of nickel, which has a strong impact on nickel accumulation in young growing tissues

Guide to Interpreting the Spring 2008 MCAS Reports for Schools and Districts

The role of intraoperative cholangiogram (IOC) during cholecystectomy is debated. The aim of the present study was to evaluate the feasibility, benefit and risk of performing systematic IOC in patients undergoing cholecystectomy for acute gallstone-related disease

The SAFRAN-ISBA-MODCOU hydrometeorological model applied over France

An edited version of this paper was published by AGU. Copyright (2008) American Geophysical UnionThe hydrometeorological model SIM consists in a meterological analysis system (SAFRAN), a land surface model (ISBA) and a hydrogeological model (MODCOU). It generates atmospheric forcing at an hourly time step, and it computes water and surface energy budgets, the river ow at more than 900 rivergauging stations, and the level of several aquifers. SIM was extended over all of France in order to have a homogeneous nation-wide monitoring of the water resources: it can therefore be used to forecast flood risk and to monitor drought risk over the entire nation. The hydrometeorologival model was applied over a 10-year period from 1995 to 2005. In this paper the databases used by the SIM model are presented, then the 10-year simulation is assessed by using the observations of daily stream-flow, piezometric head, and snow depth. This assessment shows that SIM is able to reproduce the spatial and temporal variabilities of the water fluxes. The efficiency is above 0.55 (reasonable results) for 66 % of the simulated rivergages, and above 0.65 (rather good results) for 36 % of them. However, the SIM system produces worse results during the driest years, which is more likely due to the fact that only few aquifers are simulated explicitly. The annual evolution of the snow depth is well reproduced, with a square correlation coeficient around 0.9 over the large altitude range in the domain. The stream ow observations were used to estimate the overall error of the simulated latent heat ux, which was estimated to be less than 4 %