Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

The Glaciogenic Reservoir Analogue Studies Project (GRASP): An integrated approach to unravel genesis, infill and architecture of tunnel valleys reservoirs

Tunnel galleys are common features in Palaeozoic glacigenic succession in North Afrcica and Middle East and they are amongst the most challenging target for hydrocarbon exploration and developing drilling in these regions. Similarly, these buried valleys form important groundwater reservoirs in Quaternary glaciated areas and their nature and sediment composition is critical to drive a sustainable production strategy and assess their vulnerability. Seismic resolution however, often limits the understanding of channel valleys morphology, 3D geometry and internal reservoir distribution, thus increasing the risk associated with developing effectively these reservoirs. Therefore a analogue-based predictive stratigraphical and sedimentological model can help to steer drilling strategy and reduce uncertainties and associated risks. For this purpose the GRASP joint industry programme was established four years ago focusing on an integrated study of tunnel valley infill and architecture from the southern North Sea (UK and NL). The thorough examination of existing large subsurface and outcrop data set regarding the last 3 Pleistocene glaciations in NW Europe resulted in an improved understanding of tunnel valley genesis, sedimentary process and internal architecture. This learning can be used ultimately to improve our predictive capability when exploring and developing natural resources from these geological systems.Geoscience & EngineeringCivil Engineering and Geoscience

Upstream versus downstream forcing: The response of the Golo River system, Corsica, to late quaternary climatic and eustatic oscillations

Geoscience & EngineeringCivil Engineering and Geoscience

Sound localization and quantification analysis of an automotive engine cooling module

Sound emissions of an automotive engine cooling system are studied using both single-microphone directivity measurements and a rotating beamforming technique. These measurements provide reference acoustic data on such a system and some new understanding of the effect that the radiator induces on the distribution of sound sources. Indeed, the beamforming results indicate that, above the frequency limit allowed by the Rayleigh criterion, it is possible to localize and quantify the noise sources even through the heat-exchanger core. Moreover, for the investigated operating points along the fan performance curve, the sources are always distributed at the tip of the blades and, in particular, at the leading edge. The present evidence, confirmed by the similar trends of the frequency spectra with and without the heat exchanger, leads to the conclusion that the dominant sound mechanism is the turbulence-interaction noise. Nevertheless, this turbulence is produced within the gap between the fan ring and its casing rather than generated by the radiator core. The latter appears to induce negligible acoustic transmission losses but, more significantly, is found to have a minimal influence on the aerodynamic modification of sound sources for all the analyzed operating conditions.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Wind Energ

Filtration Characterization Method as Tool to Assess Membrane Bioreactor Sludge Filterability—The Delft Experience

Prevention and removal of fouling is often the most energy intensive process in Membrane Bioreactors (MBRs), responsible for 40% to 50% of the total specific energy consumed in submerged MBRs. In the past decade, methods were developed to quantify and qualify fouling, aiming to support optimization in MBR operation. Therefore, there is a need for an evaluation of the lessons learned and how to proceed. In this article, five different methods for measuring MBR activated sludge filterability and critical flux are described, commented and evaluated. Both parameters characterize the fouling potential in full-scale MBRs. The article focuses on the Delft Filtration Characterization method (DFCm) as a convenient tool to characterize sludge properties, namely on data processing, accuracy, reproducibility, reliability, and applicability, defining the boundaries of the DFCm. Significant progress was made concerning fouling measurements in particular by using straight forward approaches focusing on the applicability of the obtained results. Nevertheless, a fouling measurement method is still to be defined which is capable of being unequivocal, concerning the fouling parameters definitions; practical and simple, in terms of set-up and operation; broad and useful, in terms of obtained results. A step forward would be the standardization of the aforementioned method to assess the sludge filtration quality.Water ManagementCivil Engineering and Geoscience

Improved Oceanographic Measurements from SAR Altimetry: Results and Scientific Roadmap from the ESA CryoSat Plus For Oceans Project

Space EngineeringAerospace Engineerin

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation